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A Preliminary Study on the Relationship between Serum Heparan Sulfate and Cancer-Related Cognitive Impairment: The Moderating Role of Oxidative Stress in Patients with Colorectal Cancer

Wang, Danhui, Wang, Teng, Zhu, Min, Sun, Jun, Zhou, Zhou, Chen, Jinghua, Teng, Liping·2022·Current Oncology
DOI 10.3390/curroncol29040219
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Abstract

Cancer-related cognitive impairment (CRCI) has been frequently reported in colorectal cancer survivors. Heparan sulfate (HS) was gradually considered to be related to cognitive disorders. The effect and potential mechanism of HS on CRCI in colorectal cancer patients were unexplored. In this study, all participants were divided into a cognitive impaired group and a cognitive normal group. The concentrations of oxidative stress factors and HS in serum were detected. Associations among HS, oxidative stress factors and CRCI were evaluated. Participants with cognitive impairment exhibited increased levels of HS, GSH, SOD and MDA, compared to the patients with normal cognitive performance. The independent significant association was found between HS and CRCI after controlling for various covariates. The higher concentrations of HS were related to the decreased cognitive performance among survivors who reported higher levels of GSH (β = 0.080, p = 0.002). Moreover, the nonlinear association between the level of HS and cognitive scores was confirmed using the restricted cubic splines (p < 0.001). These results indicated that the increased concentrations of circulating HS had a nonlinear negative connection with cognitive performance in colorectal cancer survivors, which was moderated by GSH. HS might be a new biomolecule for the identification and management of patients with CRCI.

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Metadata

Authors
Wang, D., Wang, T., Zhu, M., Sun, J., Zhou, Z., Chen, J., & Teng, L.
Venue
Current Oncology
Publisher
MDPI AG
Published
2022-04-12
Volume
29
Issue
4
Pages
2681-2694
ISSN
1718-7729
DOI
10.3390/curroncol29040219
Cited by
3
References
6
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • National Natural Science Foundation of China (82172583)
  • Top Talent Support Program for young and middle-aged people of Wuxi Health Committee (BJ 2020041)

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CoChat. (2026). Citation check: A Preliminary Study on the Relationship between Serum Heparan Sulfate and Cancer-Related Cognitive Impairment: The Moderating Role of Oxidative Stress in Patients with Colorectal Cancer. https://app.cochat.ai/papers/10.3390/curroncol29040219
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Wang, D., Wang, T., Zhu, M., Sun, J., Zhou, Z., Chen, J., & Teng, L. (2022). A Preliminary Study on the Relationship between Serum Heparan Sulfate and Cancer-Related Cognitive Impairment: The Moderating Role of Oxidative Stress in Patients with Colorectal Cancer. Current Oncology. https://doi.org/10.3390/curroncol29040219

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