Cited by 25Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactAgricultural safety and regulations

Endocrine-Disrupting Chemicals and Persistent Organic Pollutants in Infant Formulas and Baby Food: Legislation and Risk Assessments

Open access
Hatzidaki, Eleftheria, Pagkalou, Marina, Katsikantami, Ioanna, Vakonaki, Elena, Kavvalakis, Matthaios, Tsatsakis, Aristidis M., Tzatzarakis, Manolis N.·2023·Foods

Abstract

Human milk is the healthiest option for newborns, although, under specific circumstances, infant formula is a precious alternative for feeding the baby. Except for the nutritional content, infant formulas and baby food must be pollutant-free. Thus, their composition is controlled by continuous monitoring and regulated by establishing upper limits and guideline values for safe exposure. Legislation differs worldwide, although there are standard policies and strategies for protecting vulnerable infants. This work presents current regulations and directives for restricting endocrine-disrupting chemicals and persistent organic pollutants in infant formulas. Risk assessment studies, which are limited, are necessary to depict exposure variations and assess the health risks for infants from dietary exposure to pollutants.

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Crossref · 10.3390/foods12081697

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  • EDCs and persistent organic pollutants are detectable in infant formulas and baby foods, indicating continued exposure beyond the intrauterine period.

    “Regulatory and dietary risk-assessment studies further demonstrate that endocrine-disrupting chemicals and persistent organic pollutants are detectable in infant formulas and baby foods, indicating continued exposure beyond the intrauterine period and supporting continuity of exposure across early developmental stages [79].”

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  1. [41]National Research Council (US) Committee on Pesticides in the Diets of Infants and Children Pesticides in the Diets of Infants and Children 6 Pesticide Residues National Academies Press (US) Washington, DC, USA 1993 Available online: https://www.ncbi.nlm.nih.gov/books/NBK236264/ (accessed on 10 April 2023) 25144038
  2. [49]Food and Agriculture Organization of the United Nations (FAO) Code of Federal Regulations. Part 180—Tolerances and Exemptions for Pesticides Chemical Residues in Food, Title 40, Chapter I, Subchapter E, Part 180 2019 Available online: https://www.fao.org/faolex/results/details/en/c/LEX-FAOC190796/ (accessed on 18 April 2023)
  3. [70]National Research Council (US) Committee on the Health Risks of Phthalates Phthalates and Cumulative Risk Assessment: The Tasks Ahead National Academies Press (US) Washington, DC, USA 2008 10.17226/12528 25009926 · DOI
  4. [83]EFSA Technical Report of the public consultation on the ‘Draft update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials’ EFSA J. 2019 12 1747e 10.2903/sp.efsa.2019.EN-1747 PMC7008866 32626195 · DOI
  5. [115]European Commission Regulation (EU) No 1259/2011 Amending Regulation (EC) No 1881/2006 as Regards Maximum Levels for Dioxins, Dioxin-like PCBs, 3/1/2011, Official Journal of the European Union and Non Dioxin-Like PCBs in Foodstuffs. 2 December 2011 Available online: https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2011:320:0018:0023:EN:PDF (accessed on 11 April 2023)

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Authors
Hatzidaki, E., Pagkalou, M., Katsikantami, I., Vakonaki, E., Kavvalakis, M., Tsatsakis, A. M., & Tzatzarakis, M. N.
Affiliations
University of Crete (GR)
Corresponding author
  • Katsikantami, Ioanna
  • Kavvalakis, Matthaios
Venue
Foods
Publisher
MDPI AG
Published
2023-04-19
Volume
12
Issue
8
Pages
1697
ISSN
2304-8158 (ISSN-L)
OpenAlex
W4366548183
Cited by
25
References
105
Citations by year
2026: 7 · 2025: 6 · 2024: 11 · 2023: 1
FWCI
0.67
Type
journal article
Language
en
Open access
Locations
  • Foods (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
Keywords
endocrine disruptors, persistent organic pollutants, infant formula, baby food, food safety regulation, dietary exposure, infant health risk, exposure limits, food contamination

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