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Bioavailability of curcumin: Problems and promises

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Anticancer potential of curcumin: preclinical and clinical studies.

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Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

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Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

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Antioxidant and radical scavenging properties of curcumin

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The Chemistry of Curcumin: From Extraction to Therapeutic Agent

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ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN

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Dose escalation of a curcuminoid formulation

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Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

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In vitro antibacterial activity of curcumin-meropenem combination against extensively drug-resistant (XDR) bacteria isolated from burn wound infections.

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Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2

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Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review

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Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer

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Curcumin suppresses colorectal tumorigenesis via the Wnt/β‑catenin signaling pathway by downregulating Axin2

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TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

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Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development

Szydłowska, I., Nawrocka-Rutkowska, J., Brodowska, A., Marciniak, A., Starczewski, A., & Szczuko, M. (2022) · Nutrients · doi:10.3390/nu14040734 · Cited by 36

Enhanced anti-cancer effect of curcumin loaded-niosomal nanoparticles in combination with heat-killed Saccharomyces cerevisiae against human colon cancer cells

Jadid, M. F. S., Jafari-Gharabaghlou, D., Bahrami, M. K., Bonabi, E., & Zarghami, N. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104167 · Cited by 36

Phytotherapy in Integrative Oncology—An Update of Promising Treatment Options

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The Antimicrobial Activity of Curcumin and Xanthohumol on Bacterial Biofilms Developed over Dental Implant Surfaces

Alonso‐Español, A., Bravo, E., Ribeiro‐Vidal, H., Virto, L., Herrera, D., Alonso, B., & Sanz, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032335 · Cited by 35

Fighting cytokine storm and immunomodulatory deficiency: By using natural products therapy up to now

Mohammed, M. A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1111329 · Cited by 34

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

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Emerging therapeutic potential of curcumin in the management of dermatological diseases: an extensive review of drug and pharmacological activities

Kumar, B., Aggarwal, R., Prakash, U., & Sahoo, P. K. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00493-1 · Cited by 36

Reduction of Staphylococcus aureus in vitro and in milk by photodynamic inactivation using riboflavin and curcumin as photosensitizers: Cell damage and effects on product quality

Saraiva, B. B., Sestito, J. M. B., Bezerra, R. A. D., de Oliveira, G. L. M., Júnior, R. C. D. S., Machado, R. R. B., Nakamura, C. V., Alfieri, A. A., & Pozza, M. S. D. S. (2023) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2023.115120 · Cited by 35

Polyphenol encapsulated nanofibers in wound healing and drug delivery

Ejiohuo, O., Folami, S. O., Edi, D., & Isaac, J. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100184 · Cited by 37

Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases

Sun, Q., Lv, M., & Li, Y. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106476 · Cited by 35

Dietary and Nutritional Interventions for the Management of Endometriosis

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Advanced Strategies in Enhancing the Hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics, and Mechanistic Insights

Patel, J., Roy, H., Chintamaneni, P. K., Patel, R., & Bohara, R. A. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00004 · Cited by 35

Herbs and spices as functional food ingredients: A comprehensive review of their therapeutic properties, antioxidant and antimicrobial activities, and applications in food preservation

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Targeting multiple myeloma with natural polyphenols

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Effects of nanocurcumin on inflammatory factors and clinical outcomes in critically ill patients with sepsis: A pilot randomized clinical trial

Karimi, A., Mahmoodpoor, A., Kooshki, F., Niazkar, H. R., Shoorei, H., & Tarighat‐Esfanjani, A. (2020) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2020.101122 · Cited by 35

Curry versus cancer: Potential of some selected culinary spices against cancer with in vitro, in vivo, and human trials evidences

Adithya, J., Nair, B., Sreelekshmi, P., & Nath, L. R. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13285 · Cited by 35

Characterization, Classification and Authentication of Turmeric and Curry Samples by Targeted LC-HRMS Polyphenolic and Curcuminoid Profiling and Chemometrics

Núñez, N., Vidal-Casanella, O., Sentellas, S., Saurina, J., & Núñez, Ó. (2020) · Molecules · doi:10.3390/molecules25122942 · Cited by 35

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders

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Promising role of curcumin against viral diseases emphasizing COVID-19 management: A review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation

Dhar, S., & Bhattacharjee, P. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104503 · Cited by 35

Zinc-dependent histone deacetylases: Potential therapeutic targets for arterial hypertension

Kee, H. J., Kim, I., & Jeong, M. H. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115111 · Cited by 38

Protective effects of curcumin on ischemia/reperfusion injury

Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022) · Phytotherapy Research · doi:10.1002/ptr.7620 · Cited by 35

Curcuma as an anti-inflammatory component in treating osteoarthritis

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Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise

Navarro‐Hortal, M. D., Romero‐Márquez, J. M., Jiménez-Trigo, V., Xiao, J., Giampieri, F., Forbes-Hernández, T. Y., Grosso, G., Battino, M. A., Sánchez‐González, C., & Quiles, J. L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2098244 · Cited by 35

Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

Martins, A. S. D. P., ALVES, M. D. C., de Araújo, O. R. P., Camatari, F. O. D. S., Goulart, M. O. F., & Moura, F. A. (2023) · Biocell · doi:10.32604/biocell.2023.043253 · Cited by 34

Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery

Radha, R., Paul, V., Anjum, S., Bouakaz, A., Pitt, W. G., & Husseini, G. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-61278-x · Cited by 35

Mitochondria targeted nanoparticles for the treatment of mitochondrial dysfunction-associated brain disorders

Buck, A. C., Maarman, G. J., Dube, A., & Bardien, S. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1563701 · Cited by 36

Neuroactive Phytochemicals as Multi-Target Modulators of Mental Health and Cognitive Function: An Integrative Review

Ткаченко, Г. М., Buyun, L., Kołodziejska, R., Kamiński, P., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188907 · Cited by 40

Photo-physical, theoretical and photo-cytotoxic evaluation of a new class of lanthanide( iii )–curcumin/diketone complexes for PDT application

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Green Solvents Combined with Bioactive Compounds as Delivery Systems: Present Status and Future Trends

Silva, S. S., Gomes, J. M., Reis, R. L., & Kundu, S. C. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00013 · Cited by 34

Reducing Disease Activity of Inflammatory Bowel Disease by Consumption of Plant-Based Foods and Nutrients

Antoniussen, C. S., Rasmussen, H. H., Holst, M., & Lauridsen, C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.733433 · Cited by 37

Production and evaluation of novel functional extruded corn snacks fortified with ginger, bay leaves and turmeric powder

Amer, S. A., & Rizk, A. (2022) · Food Production Processing and Nutrition · doi:10.1186/s43014-022-00083-3 · Cited by 34

Clinical Efficacy of Curcumin and Vitamin E on Inflammatory‐Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple‐Blind Randomized Controlled Trial

Farshbaf‐Khalili, A., Ostadrahimi, A., Mirghafourvand‬‬‬‬‬‬‬‬‬‬‬‬‬‬, M., Ataei-Almanghadim, K., Dousti, S., & Iranshahi, A. M. (2022) · Journal of Nutrition and Metabolism · doi:10.1155/2022/6339715 · Cited by 34

Electrochemical Sensing Platform Based on Functionalized Multi-Walled Carbon Nanotubes and Metal Oxide for the Detection and Degradation Studies of Orange II Dye

Irfan, M., Shah, A., Iftikhar, F. J., Hayat, M., Ashiq, M. N., & Shah, I. (2022) · ACS Omega · doi:10.1021/acsomega.2c03641 · Cited by 34

Bioavailability enhancement of curcumin via esterification processes: A review

Agrawal, N., & Jaiswal, M. (2022) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2022.100081 · Cited by 34

Use of Spirulina platensis and Curcuma longa as Nutraceuticals in Poultry

Bondar, A., Horodincu, L., Solcan, G., & Solcan, C. (2023) · Agriculture · doi:10.3390/agriculture13081553 · Cited by 34

Development of the Amorphous Solid Dispersion of Curcumin: A Rational Selection of Polymers for Enhanced Solubility and Dissolution

Ishtiaq, M., Asghar, S., Khan, I. U., Iqbal, M. S., & Khalid, S. H. (2022) · Crystals · doi:10.3390/cryst12111606 · Cited by 33

Nanozymes for Treating Ocular Diseases

Wong, K., Wong, M., & Liu, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401309 · Cited by 33

Turmeric Essential Oil Constituents as Potential Drug Candidates: A Comprehensive Overview of Their Individual Bioactivities

Orellana-Paucar, A. M. (2024) · Molecules · doi:10.3390/molecules29174210 · Cited by 38

Injectable supramolecular hydrogels based on custom-made poly(ether urethane)s and α-cyclodextrins as efficient delivery vehicles of curcumin

Torchio, A., Cassino, C., Lavella, M., Gallina, A., Stefani, A., Boffito, M., & Ciardelli, G. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112194 · Cited by 33

Modulating effects of capsaicin on glucose homeostasis and the underlying mechanism

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Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway

Du, S., Zhu, X., Zhou, N., Zheng, W., Zhou, W., & Li, X. (2022) · Food & Function · doi:10.1039/d1fo03752h · Cited by 33

Synergistic anticancer effects of curcumin and crocin on human colorectal cancer cells

Hosseini, S. S., Reihani, R. Z., Doustvandi, M. A., Amini, M. A., Zargari, F., Baradaran, B., Yari, A., Hashemi, M., Tohidast, M., & Mokhtarzadeh, A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07719-0 · Cited by 33

The therapeutic potential of natural products for treating pancreatic cancer

He, X., Wang, N., Zhang, Y., Huang, X., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1051952 · Cited by 35

Improved Bioavailability of Curcumin in Gliadin-Protected Gold Quantum Cluster for Targeted Delivery

Mathew, M. S., Vinod, K., Jayaram, P. S., Jayasree, R. S., & Joseph, K. (2019) · ACS Omega · doi:10.1021/acsomega.9b00917 · Cited by 33

Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Feng, J., Li, Z., Tian, L., Mu, P., Hu, Y., Xiong, F., & Ma, X. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03740-9 · Cited by 33

Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia

Mishra, G., Singh, P. N. D., Molla, M., Yimer, Y. S., Ewunetie, A., Tadesse, T. Y., Ayele, T. M., & Kefale, B. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105260 · Cited by 32

Traditional Chinese medicine inhibits PD-1/PD-L1 axis to sensitize cancer immunotherapy: a literature review

Zheng, H., Wang, G., Liu, M., & Cheng, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1168226 · Cited by 32

Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

Subramaniyan, V., Lubau, N. S. A., Mukerjee, N., & Kumarasamy, V. (2023) · Toxicology Reports · doi:10.1016/j.toxrep.2023.10.005 · Cited by 35

Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

Boland, R., & Kokiko‐Cochran, O. N. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1352790 · Cited by 32

Therapeutic potential and agricultural benefits of curcumin: a comprehensive review of health and sustainability applications

Anas, M., Falak, A., Khan, A., Khattak, W. A., Nisa, S. G., Aslam, Q., Khan, K. A., Saleem, M. H., & Fahad, S. (2024) · Journal of Umm Al-Qura University for Applied Sciences · doi:10.1007/s43994-024-00200-7 · Cited by 32

A curcumin derivative hydrazinobenzoylcurcumin suppresses stem‐like features of glioblastoma cells by targeting Ca2+/calmodulin‐dependent protein kinase II

Shin, H. J., Lee, S., & Jung, H. J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27972 · Cited by 32

The gamma radiation effect on the surface morphology and optical properties of alpha-methyl curcumin: PMMA film

Jebur, J. H., HASSAN, Q. M. A., Al‐Mudhaffer, M. F., Al-Asadi, A. S., Elias, R. S., Saeed, B. A., & Emshary, C. A. (2019) · Physica Scripta · doi:10.1088/1402-4896/ab5ca0 · Cited by 32

Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Kim, S. W., Goossens, A., Libert, C., Immerseel, F. V., Staal, J., & Beyaert, R. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113866 · Cited by 32

Injectable supramolecular nanohydrogel from a micellar self-assembling calix[4]arene derivative and curcumin for a sustained drug release

Granata, G., Petralia, S., Forte, G., Sabrina Conoci, A., & Consoli, G. M. L. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110842 · Cited by 32

Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double‐blind placebo‐controlled trial

Zahedi, H., Hosseinzadeh‐Attar, M. J., Shadnoush, M., Sahebkar, A., Barkhidarian, B., Sadeghi, O., Najafi, A., Hosseini, S., Qorbani, M., Ahmadi, A., et al. (2021) · Phytotherapy Research · doi:10.1002/ptr.7179 · Cited by 35

The Effects of Curcumin Supplementation on Muscle Damage, Oxidative Stress, and Inflammatory Markers in Healthy Females with Moderate Physical Activity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Salehi, M., Mashhadi, N. S., Shekarchizadeh, P., Feizi, A., Hadi, A., & Askari, G. (2021) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_138_20 · Cited by 32

Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhang, T., He, Q., Liu, Y., Chen, Z., & Hu, H.-J. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/4471944 · Cited by 32

The Potential of Natural Products in the Treatment of Triple-negative Breast Cancer

Ke, D. Y. J., El‐Sahli, S., & Wang, L. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009622666211231140623 · Cited by 32

Does nano‐curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial

Naeini, F., Tutunchi, H., Razmi, H., Mahmoodpoor, A., Vajdi, M., Azar, P. S., Najifipour, F., Tarighat‐Esfanjani, A., & Karimi, A. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14093 · Cited by 32

Enhanced wound healing activity of nano ZnO and nano Curcuma longa in third-degree burn

Bhutta, Z. A., Ashar, A., Mahfooz, A., Khan, J. A., Saleem, M. I., Rashid, A., Aqib, A. I., Kulyar, M. F., Sarwar, I., Shoaib, M., et al. (2021) · Applied Nanoscience · doi:10.1007/s13204-020-01661-y · Cited by 32

Cannabinoid compounds in combination with curcumin and piperine display an anti-tumorigenic effect against colon cancer cells

Yüksel, B., Deniz, A. A. H., Şahi̇n, F., Şahin, K., & Türkel, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1145666 · Cited by 31

Hydrogel Bioinks of Alginate and Curcumin-Loaded Cellulose Ester-Based Particles for the Biofabrication of Drug-Releasing Living Tissue Analogs

Carvalho, J. P. F., Teixeira, M. C., Lameirinhas, N. S., Matos, F. S., Luís, J. L., Pires, L. S. O., Oliveira, H., Oliveira, J. M., Silvestre, A. J. D., Vilela, C., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c07077 · Cited by 32

Therapeutic and Preventive Potential of Plant-Derived Antioxidant Nutraceuticals

Pereira, A. G., Echave, J., Jorge, A. O. S., Nogueira‐Marques, R., Yuksek, E. N., Barciela, P., Perez-Vazquez, A., Chamorro, F., Oliveira, M. B. P. P., Carpena, M., et al. (2025) · Foods · doi:10.3390/foods14101749 · Cited by 40

Therapeutic potential of curcumin against lead-induced toxicity: A review

Abubakar, K., Mailafiya, M. M., Danmaigoro, A., Rahim, E. B. A., & Bakar, M. Z. A. (2019) · Biomedical Research and Therapy · doi:10.15419/bmrat.v6i3.528 · Cited by 31

Dog food production using curcumin as antioxidant: effects of intake on animal growth, health and feed conservation

Campigotto, G., Alba, D. F., Marchiori, M. S., dos Santos, D. S., Souza, C. F., Baldissera, M. D., Gündel, S. D. S., Ourique, A. F., Zimmer, F., Petrolli, T. G., et al. (2020) · Archives of Animal Nutrition · doi:10.1080/1745039x.2020.1769442 · Cited by 31

Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs

Arora, P., Li, W., Huang, X., Yu, W., Huang, R., Jiang, Q., & Chen, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23074038 · Cited by 31

Curcumin as a novel approach in improving lipid profile: An umbrella meta-analysis

Musazadeh, V., Roshanravan, N., Mohammadizadeh, M., Kavyani, Z., Dehghan, P., & Mosharkesh, E. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.07.021 · Cited by 31

Self-Assembled Phytochemical Nanomedicines with Enhanced Bioactivities for Effective Acute Kidney Injury Therapy

Chen, X., Ren, Q., Chen, G., Zeng, Y., Tong, Q., Ran, Y., Ma, L., Fu, P., Ma, L., & Li, X. (2023) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.2c05786 · Cited by 32

Potentials of curcumin against polycystic ovary syndrome: Pharmacological insights and therapeutic promises

Akter, T., Zahan, M. S., Nawal, N. N. A., Rahman, M. H., Tanjum, T. N., Arafat, K. I., Moni, A., Islam, M. N., & Uddin, M. J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16957 · Cited by 31

Current Applications and Trends in Rabbit Nutraceuticals

El‐Sabrout, K., Khalifah, A. M., & Ciani, F. (2023) · Agriculture · doi:10.3390/agriculture13071424 · Cited by 30

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STUDY OF TRANSLUCENT PHYTOCHEMICAL PROFILE, ADVANCED ANALYTICAL CHARACTERIZATION, MULTIVALENT PHARMACOTHERAPEUTICS ACTIVITIES, AND FUTURE ROUTE OF DEVELOPMENT OF CURCUMIN—A COMPREHENSIVE REVIEW

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