Cited by 2,720Curcumin's Biomedical ApplicationsPhytochemicals and Antioxidant ActivitiesSaffron Plant Research Studies

The DOI matches its Crossref record; 66 of the 68 references it cites were found in a registry or an index.

Curcumin: A Review of Its Effects on Human Health

Open access

Hewlings, Susan, Kalman, Douglas·2017·Foods

Open this paper in CoChat — free account Open PDF

Abstract

Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/foods6100092

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal, B. B., Kumar, A. J., & Bharti, A. C. (2003) · PubMed · Cited by 2,550
Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials
Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9432-8 · Cited by 2,224
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,139
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Guido, S., Joy, D. C., Joseph, T., Majeed, M. A., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,976
Antioxidant and radical scavenging properties of curcumin
Ak, T. P., & Gülçın, İ. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.05.003 · Cited by 1,942
The Chemistry of Curcumin: From Extraction to Therapeutic Agent
Priyadarsini, K. I. (2014) · Molecules · doi:10.3390/molecules191220091 · Cited by 1,520
ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN
Menon, V. P., & Sudheer, A. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_3 · Cited by 1,407
Dose escalation of a curcuminoid formulation
Lao, C. D., Ruffin, M. T., Normolle, D. P., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J. A., Rock, C. L., & Brenner, D. E. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-10 · Cited by 1,400

Show all 68 references

Sorted by citations

Items 601–700 of 1,001

Gut microbiota modulation by plant polyphenols in koi carp (Cyprinus carpio L.)
Zhang, R., Kang, X., Liu, L., Wang, X., Li, H., Zhu, J., Cao, Y., & Zhu, H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.977292 · Cited by 30
Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer’s Disease: Dietary Plant Polyphenols
Wang, Y., Wang, K., Yan, J., Zhou, Q., & Wang, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213886 · Cited by 32
Tuning stimuli-responsive properties of alginate hydrogels through layer-by-layer functionalization for dual-responsive dual drug release
Gundogdu, D., Alemdar, C., Turan, C., Hüsnügil, H. H., Banerjee, S., & Erel‐Göktepe, I. (2023) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2023.132213 · Cited by 29
Therapeutic Effects of Curcumin Derivatives against Obesity and Associated Metabolic Complications: A Review of In Vitro and In Vivo Studies
Moetlediwa, M. T., Ramashia, R., Pheiffer, C., Titinchi, S. J. J., Mazibuko-Mbeje, S. E., & Jack, B. U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814366 · Cited by 29
Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway
Fang, G., Chen, S., Huang, Q., Chen, L., & Liao, D. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9120 · Cited by 29
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer
Kujundžić, R. N., Stepanić, V., Milković, L., Gašparović, A. Č., Tomljanović, M., & Gall‐Tros̆elj, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051180 · Cited by 31
Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer
Eskiler, G. G., Şahin, E., Özkan, A. D., Çilingir‐Kaya, Ö. T., & Kaleli, S. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1670216 · Cited by 29
Chemotherapy-Mediated Neuronal Aberration
Jaiswara, P. K., & Shukla, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16081165 · Cited by 30
Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments
Al‐Shuhaib, M. B. S., & Al‐Shuhaib, J. M. B. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401754 · Cited by 29
Application of computer vision technique for physical quality monitoring of turmeric slices during direct solar drying
Sharma, S., Dhalsamant, K., & Tripathy, P. P. (2018) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-018-9968-0 · Cited by 28
Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
Karimi, S., Khorsandi, L., & Nejaddehbashi, F. (2019) · JBRA · doi:10.5935/1518-0557.20190031 · Cited by 28
The impact of curcumin-graphene based nanoformulation on cellular interaction and redox-activated apoptosis: An in vitro colon cancer study
Al-Ani, L. A., Kadir, F. A., Hashim, N. M., Julkapli, N. M., Seyfoddin, A., Lu, J., Alsaadi, M. A., & Yehye, W. A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05360 · Cited by 28
Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model
Banji, D., Banji, O. J. F., & Srinivas, K. (2021) · BioMed Research International · doi:10.1155/2021/6645720 · Cited by 28
Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associated with divisome disruption
Polaquini, C. R., Marques, B. C., Ayusso, G. M., Morão, L. G., Sardi, J. D. C. O., Campos, D. L., da Silva, I. C., Cavalca, L. B., Scheffers, D., Rosalen, P. L., et al. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104668 · Cited by 28
Endophytic Microbial Diversity: A New Hope for the Production of Novel Anti-tumor and Anti-HIV Agents as Future Therapeutics
Banyal, A., Thakur, V., Thakur, R., & Kumar, P. (2021) · Current Microbiology · doi:10.1007/s00284-021-02359-2 · Cited by 28
Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro
Zibaei, Z., Babaei, E., Zamani, A. R. N., Rahbarghazi‬, R., & Azeez, H. J. (2021) · Cancer Nanotechnology · doi:10.1186/s12645-020-00074-4 · Cited by 28
Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway
Lv, Y., Cao, R., Liu, H., Su, X., Lü, G., Ma, J., & Chan, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126570 · Cited by 28
Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells
Erkısa, M., Sarıman, M., Geyik, Ö. G., Geyik, C., Stanojković, T., & Ulukaya, E. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210628131409 · Cited by 27
Diet and redox state in maintaining skeletal muscle health and performance at high altitude
Rathor, R., Suryakumar, G., & Singh, S. N. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.024 · Cited by 28
Curcumin Targeting Non-Coding RNAs in Colorectal Cancer: Therapeutic and Biomarker Implications
Li, J., Chai, R., Chen, Y., Zhao, S., Bian, Y., & Wang, X. (2022) · Biomolecules · doi:10.3390/biom12101339 · Cited by 28
Can Nutrition Play a Role in Ameliorating Digital Eye Strain?
Lem, D. W., Gierhart, D. L., & Davey, P. G. (2022) · Nutrients · doi:10.3390/nu14194005 · Cited by 33
A stable delivery system for curcumin: Fabrication and characterization of self-assembling acylated kidney bean protein isolate nanogels
Yu, Z., Gao, Y., Shang, Z., Wang, T., He, X., Lei, J., Tai, F., Zhang, L., & Chen, Y. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138526 · Cited by 28
Natural Compounds for Preventing Age-Related Diseases and Cancers
Ki, M., Youn, S., Kim, D. H., & Pack, S. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147530 · Cited by 30
Mechanisms and therapeutic potential of pharmacological agents targeting inflammasomes
Li, H., Liu, T., Shi, X., Du, H., Cai, C., Yang, D., Qu, L., Dou, H., Jiao, B., & Jiao, B. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118164 · Cited by 29
Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
Smail, S. W., Bergsten, P., Taha, K. O., Yashooa, R. K., Hawezy, D. J., Abbas, M. A., & Shekha, M. S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1695200 · Cited by 27
Curcumin-based biocompatible nanocarriers: a contemporary perspective in functional foods and biomedical applications
Alshammari, E. M. (2025) · Discover Nano · doi:10.1186/s11671-025-04379-4 · Cited by 35
Does Turmeric/curcumin Supplementation Change Anthropometric Indices in Patients with Non-alcoholic Fatty Liver Disease? A Systematic Review and Meta-analysis of Randomized Controlled Trials
Jafarirad, S., Mansoori, A., Adineh, A., Panahi, Y., Hadi, A., & Goodarzi, R. (2019) · Clinical Nutrition Research · doi:10.7762/cnr.2019.8.3.196 · Cited by 27
Effect of the aqueous root extract of Curcuma longa L. (turmeric) against thermally oxidized oil-induced hematological, biochemical and histopathological alterations
Abdallah, A. A. M., El-Deen, N. A. M. N., El-Aziz, H. I. A., & Neamat‐Allah, A. N. F. (2020) · Comparative Clinical Pathology · doi:10.1007/s00580-020-03108-w · Cited by 27
Benefits of turmeric supplementation for skin health in chronic diseases: a systematic review
da Mata, I. R., da Mata, S. R., Menezes, R. C. R., Faccioli, L. S., Peres, K. K., & Bosco, S. M. D. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1798353 · Cited by 27
An Overview of Nanoformulated Nutraceuticals and their Therapeutic Approaches
De, S., Agraharam, G., Keerthana, V., Girigoswami, A., & Girigoswami, K. (2020) · Current Nutrition & Food Science · doi:10.2174/1573401316999200901120458 · Cited by 27
Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta (1-42)
Hacıoğlu, C., Kar, F., Kar, E., Kara, Y., & Kanbak, G. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02511-2 · Cited by 27
Paclitaxel and curcumin co-loaded mixed micelles: Improving in vitro efficacy and reducing toxicity against Abraxane®
Riedel, J., Calienni, M. N., Bernabeu, E., Calabró, V., Martínez, J. M. L., Prieto, M. J., González, L., Martinez, C. S., Alonso, S. D. V., Montanari, J., et al. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102343 · Cited by 27
The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview
Casani-Cubel, J., Benlloch, M., Sanchis-Sanchis, C. E., Marín, R., Lajara-Romance, J. M., & Ortí, J. E. D. L. R. (2021) · Metabolites · doi:10.3390/metabo11020120 · Cited by 31
Dexamethasone and Fumaric Acid Ester Conjugate Synergistically Inhibits Inflammation and NF-κB in Macrophages
Genito, C. J., Eckshtain‐Levi, M., Piedra-Quintero, Z. L., Krovi, S. A., Kroboth, A., Stiepel, R. T., Guerau‐de‐Arellano, M., Bachelder, E. M., & Ainslie, K. M. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00200 · Cited by 27
Curcumin and Biochemical Parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)—A Review
Różański, G., Kujawski, S., Newton, J. L., Zalewski, P., & Słomko, J. (2021) · Nutrients · doi:10.3390/nu13082654 · Cited by 27
Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation
Rutz, J., Benchellal, A., Kassabra, W., Maxeiner, S., Bernd, A., Kippenberger, S., Zöller, N. N., Chun, F. K. ‐., Juengel, E., & Blaheta, R. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189966 · Cited by 27
Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management
Waiz, M., Alvi, S. S., & Khan, M. S. (2021) · EXCLI journal · doi:10.17179/excli2021-4453 · Cited by 30
Emulsion gels and oil-filled aerogels as curcumin carriers: Nanostructural characterization of gastrointestinal digestion products
Fontes‐Candia, C., Martínez, J. C., López‐Rubio, A., Salvia‐Trujillo, L., Martín‐Belloso, O., & Martínez‐Sanz, M. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132877 · Cited by 27
Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors
Pawar, H. D., Mahajan, U. B., Nakhate, K. T., Agrawal, Y. O., Patil, C. R., Meeran, M. F. N., Sharma, C., Ojha, S. K., & Goyal, S. N. (2022) · Life · doi:10.3390/life12050624 · Cited by 27
Effects of Dietary Nano-Curcumin Supplementation on Growth Performance, Glucose Metabolism, and Endoplasmic Reticulum Stress in Juvenile Largemouth Bass, Micropterus salmoides
Bao, X., Chen, M., Yue, Y., Liu, H., Yang, Y., Yu, H. M., Yu, Y., & Duan, N. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.924569 · Cited by 27
Inflammasome-targeting natural compounds in inflammatory bowel disease: Mechanisms and therapeutic potential
Xu, Q., Sun, W., Zhang, J., Mei, Y., Bao, J., Hou, S., Zhou, X., & Mao, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.963291 · Cited by 28
Cellulose nanocrystals based delivery vehicles for anticancer agent curcumin
Kumar, R., & Chauhan, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.077 · Cited by 27
Clay-Based Hydrogels as Drug Delivery Vehicles of Curcumin Nanocrystals for Topical Application
Ruggeri, M., Sánchez‐Espejo, R., Casula, L., Barbosa, R. D. M., Sandri, G., Cardia, M. C., Lai, F., & Viseras, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122836 · Cited by 27
Overview of Curcumin and Piperine Effects on Glucose Metabolism: The Case of an Insulinoma Patient’s Loss of Consciousness
Servida, S., Panzeri, E., Tomaino, L., Marfia, G., Garzia, E., Appiani, G. C., Moroncini, G., Colonna, V. D. G., Vecchia, C. L., & Vigna, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076621 · Cited by 27
L-lysine Functionalized Mesoporous Silica Hybrid Nanoparticles for pH-Responsive Delivery of Curcumin
Santhamoorthy, M., Ramkumar, V., Thirupathi, K., Gnanasekaran, L., Karuppannan, V., Phan, T. T. V., & Kim, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061631 · Cited by 27
Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats
Wu, J., Li, M., Huang, N., Guan, F., Luo, H., Chen, L., Wei, G., Li, M., Lin, Z., Su, Z., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01067 · Cited by 27
Impact of Thermal Processing on the Composition of Curcuma longa Rhizome
Zagórska, J., Kukula-Koch, W. A., Czop, M., Iłowiecka, K., & Koch, W. (2023) · Foods · doi:10.3390/foods12163086 · Cited by 27
Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review
Tuong, D. T. C., Moniruzzaman, M., Smirnova, E., Chin, S., Sureshbabu, A., Karthikeyan, A., & Min, T. (2023) · Antioxidants · doi:10.3390/antiox12091700 · Cited by 27
Phytochemicals: a new arsenal in drug discovery
Ahmed, M. H., Karkush, S. I., Ali, S. A., & Mohammed, A. A. (2024) · International Journal of Medical Science and Dental Health · doi:10.55640/ijmsdh-10-01-03 · Cited by 27
Intonation of Nrf2 and Hif1-α pathway by curcumin prophylaxis: A potential strategy to augment survival signaling under hypoxia
Mathew, T., & Sarada, S. K. S. (2018) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2018.09.008 · Cited by 27
miR‐142‐3p/5p role in cancer: From epigenetic regulation to immunomodulation
Zareifar, P., Ahmed, H. M., Ghaderi, P., Farahmand, Y., Rahnama, N., Esbati, R., Moradi, A., Yazdani, O., & Sadeghipour, Y. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3931 · Cited by 28
Development of plant-based whole egg analogs using emulsion technology
Zhou, H., Vu, G., Ju, Q., & McClements, D. J. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114406 · Cited by 26
Curcumin and nano‐curcumin applications in psychiatric disorders
Mohammadzadeh, R., Fathi, M., Pourseif, M. M., Omidi, Y., Farhang, S., Barzegar-Jalali, M., Valizadeh, H., Nakhlband, A., & Adibkia, K. (2024) · Phytotherapy Research · doi:10.1002/ptr.8265 · Cited by 27
Targeting Gut Microbiota with Probiotics and Phenolic Compounds in the Treatment of Atherosclerosis: A Comprehensive Review
Neto, J. P. R. C., Freire, M. O. D. L., Lemos, D. E. D. A., Alves, R. M. F. R., Cardoso, E. F. D. F., Balarini, C. M., Duman, H., Karav, S., de Souza, E. L., & Alves, J. L. D. B. (2024) · Foods · doi:10.3390/foods13182886 · Cited by 26
Turmeric (Curcuma longa): an insight into its food applications, phytochemistry and pharmacological properties
Jikah, A. N., & Edo, G. I. (2024) · Vegetos · doi:10.1007/s42535-024-01038-4 · Cited by 31
Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents
Lupu, A., Bercea, M., Avădanei, M., Grădinaru, L. M., Nita, L. E., & Grădinaru, V. R. (2024) · Macromolecular Materials and Engineering · doi:10.1002/mame.202400341 · Cited by 26
Applications and Advantages of Cellulose–Chitosan Biocomposites: Sustainable Alternatives for Reducing Plastic Dependency
Darmenbayeva, A. S., Zhussipnazarova, G., Rajasekharan, R., Massalimova, B. K., Zharlykapova, R. B., Nurlybayeva, А. N., Mukazhanova, Z., Aubakirova, G., Begenova, B., Manapova, S., et al. (2024) · Polymers · doi:10.3390/polym17010023 · Cited by 26
Curcumin in Ophthalmology: Mechanisms, Challenges, and Emerging Opportunities
Ribeiro, A. C., Oliveira, D. M. D. L., & Cabral-Marques, H. M. (2025) · Molecules · doi:10.3390/molecules30030457 · Cited by 26
Regulation of goat whey protein complex interfacial structures by gum Arabic to improve emulsion performance for curcumin delivery and application.
Zhao, S.-L., Li, K., Huang, H., Zhao, P., Su, S.-P., Mcclements, D., Chen, S., Ma, C.-C., Liu, X.-B., & Liu, F.-G. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123782 · Cited by 28
Liposomes: recent progress on nanoparticles production and their usage in medicine
Peruš, M., Marevci, M. K., & Kotnik, P. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214585 · Cited by 29
A new family of fullerene derivatives: fullerene-curcumin conjugates for biological and photovoltaic applications
Castro, E., Ceron, M. R., Garcia, A. H., Kim, Q., Etcheverry-Berríos, Á., Morel, M. J., Torres, R. D., Qian, W., Martinez, Z., Méndez, L., et al. (2018) · RSC Advances · doi:10.1039/c8ra08334g · Cited by 26
Trans -to- cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry
Marazzi, M., Francés‐Monerris, A., Mourer, M., Pasc, A., & Monari, A. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp06565b · Cited by 26
Autoimmune Hepatitis Associated With Turmeric Consumption
Lee, B. S., Bhatia, T., Chaya, C. T., Wen, R., Taira, M. T., & Lim, B. S. (2020) · ACG Case Reports Journal · doi:10.14309/crj.0000000000000320 · Cited by 26
In vitro antibacterial activity and durability of a nano-curcumin-containing pulp capping agent combined with antimicrobial photodynamic therapy
Pourhajibagher, M., Omrani, L. R., Noroozian, M., Ghorbanzadeh, Z., & Bahador, A. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102150 · Cited by 26
Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation
Kostrzewa, T., Wołosewicz, K., Jamrozik, M., Drzeżdżon, J., Siemińska, J., Jacewicz, D., Górska‐Ponikowska, M., Kołaczkowski, M., Łaźny, R., & Kuban‐Jankowska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910368 · Cited by 26
The Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin
Mukherjee, S., Mishra, A. K., Peer, G. D. G., Bagabir, S. A., Haque, S., Pandey, R. P., Raj, V. S., Jain, N. K., Pandey, A., & Kar, S. K. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.767493 · Cited by 30
Synergistic effects of botanical curcumin-induced programmed cell death on the management of Spodoptera litura Fabricius with avermectin
Cui, G., Yuan, H., He, W., Deng, Y., Sun, R., & Zhong, G. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113097 · Cited by 27
Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases
Boscariol, R., de Oliveira, J. M., Baldo, D. Â., Balcão, V. M., & Vila, M. M. D. C. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.01.023 · Cited by 29
Turmeric-Fortified Cow and Soya Milk: Golden Milk as a Street Food to Support Consumer Health
Idowu‐Adebayo, F., Fogliano, V., & Linnemann, A. R. (2022) · Foods · doi:10.3390/foods11040558 · Cited by 26
Can Antioxidants Reduce the Toxicity of Bisphenol?
Mączka, W. K., Grabarczyk, M., & Wińska, K. (2022) · Antioxidants · doi:10.3390/antiox11020413 · Cited by 26
Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis
Xiao, J., Cai, X., Zhou, W., Wang, R., & Ye, Z. (2022) · Bioengineered · doi:10.1080/21655979.2022.2066760 · Cited by 26
Curcumin-PLGA based nanocapsule for the fluorescence spectroscopic detection of dopamine
Zakaria, H., Kurdi, R. E., & Patra, D. (2022) · RSC Advances · doi:10.1039/d2ra01679f · Cited by 26
Natural and Naturally Derived Photoinitiating Systems for Light-Based 3D Printing
Vazquez‐Martel, C., Mainik, P., & Blasco, E. (2022) · Organic Materials · doi:10.1055/a-1976-0453 · Cited by 26
Inhalation of L-arginine-modified liposomes targeting M1 macrophages to enhance curcumin therapeutic efficacy in ALI
Jiang, L., Guo, P., Ju, J., Zhu, X., Wu, S., & Dai, J. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.11.017 · Cited by 26
Technological Interventions Enhancing Curcumin Bioavailability in Wound-Healing Therapeutics
Singh, H., Dhanka, M., Yadav, I., Gautam, S., Bashir, S. M., Mishra, N. C., Arora, T., & Hassan, S. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0085 · Cited by 26
Advances of metallodrug-amyloid β aggregation inhibitors for therapeutic intervention in neurodegenerative diseases: Evaluation of their mechanistic insights and neurotoxicity
Khan, H. Y., Ahmad, A., Hassan, M. N., Khan, Y. H., Arjmand, F., & Khan, R. H. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215580 · Cited by 26
Acceleration of turmeric drying using convection and microwave‐assisted drying technique: An optimization approach
Monton, C., Luprasong, C., & Charoenchai, L. (2019) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.14096 · Cited by 26
Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products
Schaf, J., Damstra‐Oddy, J., & Williams, R. S. B. (2019) · The International Journal of Developmental Biology · doi:10.1387/ijdb.190228rw · Cited by 24
The Role of Imidazolium-Based Surface-Active Ionic Liquid to Restrain the Excited-State Intramolecular H-Atom Transfer Dynamics of Medicinal Pigment Curcumin: A Theoretical and Experimental Approach
Rani, S., Bagchi, D., Pal, U., Kumari, M., Sharma, M., Bera, A., Shabir, J., Pal, S. K., Saha‐Dasgupta, T., & Mozumdar, S. (2020) · ACS Omega · doi:10.1021/acsomega.0c02438 · Cited by 26
Curcumin and Gut Microbiota: A Narrative Overview with Focus on Glycemic Control
Servida, S., Piontini, A., Gori, F., Tomaino, L., Moroncini, G., Colonna, V. D. G., Vecchia, C. L., & Vigna, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147710 · Cited by 27
Exploring the Therapeutic Potential of Bioactive Compounds from Plant Sources
Chintada, V., & Golla, N. (2025) · Sustainable landscape planning and natural resources management · doi:10.1007/978-3-031-76859-0_15 · Cited by 38
Valorization of Fruit and Vegetable Waste: An Approach to Focusing on Extraction of Natural Pigments
Ramzan, K., Zehra, S. H., Balčiūnaitienė, A., Viškelis, P., & Viškelis, J. (2025) · Foods · doi:10.3390/foods14081402 · Cited by 25
Neuroprotective expression of turmeric and curcumin
Abbas, S., Latif, M. S., Shafie, N. S., Ghazali, M. I., & Kormin, F. B. (2020) · Food Research · doi:10.26656/fr.2017.4(6).363 · Cited by 25
Curcumin and n-acetylcysteine cocrystal produced with supercritical solvent: characterization, solubility, and preclinical evaluation of antinociceptive and anti-inflammatory activities
Paulazzi, A. R., Alves, B. O., Zilli, G. A. L., dos Santos, A. E., Petry, F., Soares, K. D., Danielli, L. J., Pedroso, J., Apel, M. A., Aguiar, G. P. S., et al. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00917-5 · Cited by 25
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin
Barra, V., Chiavetta, R. F., Titoli, S., Provenzano, I. M., Carollo, P. S., & Leonardo, A. D. (2022) · Genes · doi:10.3390/genes13071125 · Cited by 28
Designing suture-proof cell-attachable copolymer-mediated and curcumin- β-cyclodextrin inclusion complex loaded aliphatic polyester-based electrospun antibacterial constructs
Sharma, D., Dhingra, S., Banerjee, A., Saha, S., Bhattacharyya, J., & Satapathy, B. K. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.204 · Cited by 25
Slow release curcumin-containing soy protein nanoparticles as anticancer agents for osteosarcoma: synthesis and characterization
Zare‐Zardini, H., Soltaninejad, H., Ghorani‐Azam, A., Moghadam, R. N., Haddadzadegan, N., Ansari, M., Saeed-Banadaky, S. H., Sobhan, M. R., Mozafari, S., & Zahedi, M. (2022) · Progress in Biomaterials · doi:10.1007/s40204-022-00197-4 · Cited by 25
Curcumin as adjuvant therapy to improve remission in myeloma patients: A pilot randomized clinical trial.
Santosa, D., Suharti, C., Riwanto, I., Dharmana, E., Pangarsa, E. A., Setiawan, B., Suyono, S., Tobing, M. L., Suhartono, S., & Hadisapurto, S. (2022) · PubMed Central · doi:10.22088/cjim.13.2.9 · Cited by 25
Enhancing the Amyloid-β Anti-Aggregation Properties of Curcumin via Arene-Ruthenium(II) Derivatization
Cuccioloni, M., Cecarini, V., Bonfili, L., Pettinari, R., Tombesi, A., Pagliaricci, N., Petetta, L., Angeletti, M., & Eleuteri, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158710 · Cited by 27
Curcumin Remedies Testicular Function and Spermatogenesis in Male Mice with Low-Carbohydrate-Diet-Induced Metabolic Dysfunction
Tsao, C., Ke, P.-S., Yang, H., Chang, T.-C., & Liu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710009 · Cited by 25
Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety
Froldi, G., & Ragazzi, E. (2022) · Molecules · doi:10.3390/molecules27207110 · Cited by 27
Role of curcumin and its nanoformulations in the treatment of neurological diseases through the effects on stem cells
Sabouni, N., Marzouni, H. Z., Palizban, S., Meidaninikjeh, S., Kesharwani, P., Jamialahmadi, T., & Sahebkar, A. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2141755 · Cited by 27
Current advancements related to phytobioactive compounds based liposomal delivery for neurodegenerative diseases
Khot, K. B., Gopan, G., Bandiwadekar, A., & Jose, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101806 · Cited by 28
A systematic review and meta‐analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders
Hosseini, H., Ghavidel, F., Panahi, G., Majeed, M. A., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7730 · Cited by 25
The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial
Gashti, N. G., Ghanbari-Homaie, S., Shaseb, E., Abbasalizadeh, S., & Mirghafourvand‬‬‬‬‬‬‬‬‬‬‬‬‬‬, M. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01295-5 · Cited by 25
The impact of curcumin on migraine: A comprehensive review
Heidari, H., Shojaei, M., Askari, G., Majeed, M. A., Bagherniya, M., Barreto, G. E., & Sahebkar, A. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114910 · Cited by 25
The effect of an anti-inflammatory diet on chronic pain: a pilot study
Sala‐Climent, M., de Coca, T. L., Guerrero, M. D., Muñoz, F. J., López-Ruíz, M. A., Moreno, L., Alacreu, M., & Dea‐Ayuela, M. A. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1205526 · Cited by 27
The Effects of Curcumin on Astrocytes in Common Neurodegenerative Conditions
Alameri, A. A., Ghanni, M. U., Ali, A., Singh, M., Al-Gazally, M. E., Almulla, A. F., Ramírez‐Coronel, A. A., Mustafa, Y. F., Gupta, R., Obaid, R. F., et al. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230502143131 · Cited by 32
Regulation of mitophagy and mitochondrial function: Natural compounds as potential therapeutic strategies for Parkinson's disease
Liang, H., Ma, Z., Zhong, W., Liu, J., Sugimoto, K., & Chen, H. (2024) · Phytotherapy Research · doi:10.1002/ptr.8156 · Cited by 27
Formulation, development and evaluation of hyaluronic acid-conjugated liposomal nanoparticles loaded with regorafenib and curcumin and their in vitro evaluation on colorectal cancer cell lines
Shnaikat, S. G., Shakya, A. K., & Bardaweel, S. K. (2024) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2024.102099 · Cited by 24

Authors: Hewlings, S., & Kalman, D.
Affiliations: Central Michigan University (US)
Nova Southeastern University (US)
Corresponding author: Hewlings, Susan
ORCID: Hewlings, Susan
Kalman, Douglas
Venue: Foods
Publisher: MDPI AG
Published: 2017-10-22
Volume: 6
Issue: 10
Pages: 92
ISSN: 2304-8158 (ISSN-L)
DOI: 10.3390/foods6100092
PMC: PMC5664031
OpenAlex: W2766083858
Cited by: 2,720
References: 68
Citations by year: 2026: 336 · 2025: 364 · 2024: 383 · 2023: 399 · 2022: 415 · 2021: 380 · 2020: 258 · 2019: 125 · 2018: 54 · 2017: 1
FWCI: 7.72
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Foods (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Saffron Plant Research Studies
Keywords: curcumin, turmeric, polyphenols, bioavailability, piperine, antioxidant activity, anti-inflammatory activity, oxidative stress, metabolic syndrome, arthritis, anxiety, hyperlipidemia, exercise-induced inflammation, muscle soreness, post-exercise recovery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Curcumin: A Review of Its Effects on Human Health

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks