A Comprehensive Systematic Review Coupled with an Interacting Network Analysis Identified Candidate Genes and Biological Pathways Related to Bovine Temperament
Open accessAbstract
Comprehension of the genetic basis of temperament has been improved by recent advances in the identification of genes and genetic variants. However, due to the complexity of the temperament traits, the elucidation of the genetic architecture of temperament is incomplete. A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to analyze candidate genes related to bovine temperament, using bovine as the population, SNPs and genes as the exposure, and temperament test as the outcome, as principal search terms for population, exposure, and outcome (PEO) categories to define the scope of the search. The search results allowed the selection of 36 articles after removing duplicates and filtering by relevance. One hundred-two candidate genes associated with temperament traits were identified. The genes were further analyzed to construct an interaction network using the STRING database, resulting in 113 nodes and 346 interactions and the identification of 31 new candidate genes for temperament. Notably, the main genes identified were SST and members of the Kelch family. The candidate genes displayed interactions with pathways associated with different functions such as AMPA receptors, hormones, neuronal maintenance, protein signaling, neuronal regulation, serotonin synthesis, splicing, and ubiquitination activities. These new findings demonstrate the complexity of interconnected biological processes that regulate behavior and stress response in mammals. This insight now enables our targeted analysis of these newly identified temperament candidate genes in bovines.
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A meta-analysis identified the stress-responsive gene SST and members of the Kelch family as key regulators of cattle temperament.
“Complementing this, a meta-analysis by Ruiz et al. [130] identified the stress-responsive gene SST and members of the synaptic function-related Kelch family as key regulators of cattle temperament.”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [130]
The Abstract identifies SST and Kelch-family members as the main genes found through a systematic review and interaction-network analysis. The Discussion links SST to stress response and Kelch-family members to synaptic responses. But the Conclusions call them potential candidate genes, not established key regulators, and the paper describes a systematic review rather than a meta-analysis. (LLM, conf=0.86)
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The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution
Liu, Y., Dao, W., Gao, R., Fan, X., Yang, R., & Miao, Y. (2026) · Animals · doi:10.3390/ani16050776 · Cited by 1 · see citing works
- Authors
- Ruiz-De-La-Cruz, G., Welsh, T. H., Randel, R. D., & Sifuentes-Rincón, A. M.
- Affiliations
- Instituto Politécnico Nacional (MX)
- Texas A&M University (US)
- Texas A&M AgriLife Research, Overton, TX 75684, USA
- Laboratorio de Biotecnología Animal, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2024-07-25
- Volume
- 15
- Issue
- 8
- Pages
- 981
- ISSN
- 2073-4425 (ISSN-L)
- PMC
- PMC11354074
- OpenAlex
- W4400981636
- Cited by
- 4
- References
- 76
- Citations by year
- 2026: 1 · 2025: 3
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Genes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Instituto Politécnico Nacional (20241271)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- candidate genes, single nucleotide polymorphisms, gene interaction networks, serotonin transporter, AMPA receptors, stress response, animal behavior genetics, biological pathways, cattle
- MeSH terms
- Animals, Cattle, Temperament, Polymorphism, Single Nucleotide, Gene Regulatory Networks, Protein Interaction Maps
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