Prenatal transportation stress alters genome-wide DNA methylation in suckling Brahman bull calves1,2
Open accessAbstract
The objective of this experiment was to identify genome-wide differential methylation of DNA in young prenatally stressed (PNS) bull calves. Mature Brahman cows (n = 48) were transported for 2-h periods at 60 ± 5, 80 ± 5, 100 ± 5, 120 ± 5, and 140 ± 5 d of gestation or maintained as nontransported Controls (n = 48). Methylation of DNA from white blood cells from a subset of 28-d-old intact male offspring (n = 7 PNS; n = 7 Control) was assessed via reduced representation bisulfite sequencing. Samples from PNS bulls contained 16,128 CG, 226 CHG, and 391 CHH (C = cytosine; G = guanine; H = either adenine, thymine, or cytosine) sites that were differentially methylated compared to samples from Controls. Of the CG sites, 7,407 were hypermethylated (at least 10% more methylated than Controls; P ≤ 0.05) and 8,721 were hypomethylated (at least 10% less methylated than Controls; P ≤ 0.05). Increased DNA methylation in gene promoter regions typically results in decreased transcriptional activity of the region. Therefore, differentially methylated CG sites located within promoter regions (n = 1,205) were used to predict (using Ingenuity Pathway Analysis software) alterations to canonical pathways in PNS compared with Control bull calves. In PNS bull calves, 113 pathways were altered (P ≤ 0.05) compared to Controls. Among these were pathways related to behavior, stress response, metabolism, immune function, and cell signaling. Genome-wide differential DNA methylation and predicted alterations to pathways in PNS compared with Control bull calves suggest epigenetic programming of biological systems in utero.
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In prenatally stressed cattle, GRIK3 has recently been identified among genes with the most significant hypomethylation of intronic CpG sites, a process thought to downregulate gene expression.
“In prenatally stressed cattle, GRIK3 has recently been identified among genes with the most significant hypomethylation of intronic CpG sites, a process thought to downregulate gene expression (Littlejohn et al., 2018).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Littlejohn et al., 2018
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Glutamate receptors in domestication and modern human evolution
O’Rourke, T., & Boeckx, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.004 · Cited by 50 · see citing works
Ruiz-De-La-Cruz, G., Welsh, T. H., Randel, R. D., & Sifuentes-Rincón, A. M. (2024) · Genes · doi:10.3390/genes15080981 · Cited by 4 · see citing works
Self-citation
- Authors
- Littlejohn, B. P., Price, D. M., Neuendorff, D. A., Carroll, J. A., Vann, R. C., Riggs, P. K., Riley, D. G., Long, C. R., Welsh, T. H., & Randel, R. D.
- Affiliations
- Texas A&M University (US)
- USDA-ARS, Livestock Issues Research Unit, Lubbock, TX
- Mississippi State University (US)
- Corresponding author
- Randel, Ronald D
- Venue
- Journal of Animal Science
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-28
- Volume
- 96
- Issue
- 12
- Pages
- 5075-5099
- ISSN
- 0021-8812 (ISSN-L)
- 1525-3163
- PMC
- PMC6276578
- OpenAlex
- W2889322346
- Cited by
- 31
- References
- 87
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Animal Science (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Texas A&M AgriLife Research, Western Regional project (TEX03212)
- Hatch project (H-9022)
- TAMU One Health Initiative
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- prenatal stress, DNA methylation, epigenetic programming, Brahman cattle, bull calves, gestational age, stress response pathways, promoter methylation, leukocytes
- MeSH terms
- Animals, Animals, Suckling, Cattle, DNA, Female, Leukocytes, Male, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Physiological, Transportation, Genome, DNA Methylation, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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