The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Signaling Pathways in Exosomes Biogenesis, Secretion and Fate
Open accessAbstract
Exosomes are small extracellular vesicles (30–100 nm) derived from the endosomal system, which have raised considerable interest in the last decade. Several studies have shown that they mediate cell-to-cell communication in a variety of biological processes. Thus, in addition to cell-to-cell direct interaction or secretion of active molecules, they are now considered another class of signal mediators. Exosomes can be secreted by several cell types and retrieved in many body fluids, such as blood, urine, saliva and cerebrospinal fluid. In addition to proteins and lipids, they also contain nucleic acids, namely mRNA and miRNA. These features have prompted extensive research to exploit them as a source of biomarkers for several pathologies, such as cancer and neurodegenerative disorders. In this context, exosomes also appear attractive as gene delivery vehicles. Furthermore, exosome immunomodulatory and regenerative properties are also encouraging their application for further therapeutic purposes. Nevertheless, several issues remain to be addressed: exosome biogenesis and secretion mechanisms have not been clearly understood, and physiological functions, as well as pathological roles, are far from being satisfactorily elucidated.
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Cites
1 retracted
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling
Taylor, D. D., Akyol, S., & Gercel-Taylor, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1534 · Cited by 297
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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Membrane vesicles as conveyors of immune responses
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
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B lymphocytes secrete antigen-presenting vesicles.
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Rab27a and Rab27b control different steps of the exosome secretion pathway
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Cited by
Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346
Exosomes and Ectosomes in Intercellular Communication
Meldolesi, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.059 · Cited by 944
Review on Strategies and Technologies for Exosome Isolation and Purification
Chen, J., Li, P., Zhang, T., Xu, Z., Huang, X., Wang, R., & Du, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.811971 · Cited by 585
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Sardar Sinha, M., Ansell-Schultz, A., Civitelli, L., Hildesjö, C., Larsson, M., Lannfelt, L., Ingelsson, M., & Hallbeck, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1868-1 · Cited by 527
The potential of endurance exercise-derived exosomes to treat metabolic diseases
Safdar, A., Saleem, A., & Tarnopolsky, M. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.76 · Cited by 463
Metadata
- Authors
- Urbanelli, L., Magini, A., Buratta, S., Brozzi, A., Sagini, K., Polchi, A., Tancini, B., & Emiliani, C.
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2013-03-28
- Volume
- 4
- Issue
- 2
- Pages
- 152-170
- ISSN
- 2073-4425 (ISSN-L)
- OpenAlex
- W2099111325
- Cited by
- 355
- References
- 120
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- Urbanelli, L., Magini, A., Buratta, S., Brozzi, A., Sagini, K., Polchi, A., Tancini, B., & Emiliani, C. (2013). Signaling Pathways in Exosomes Biogenesis, Secretion and Fate. Genes. https://doi.org/10.3390/genes4020152
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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