The DOI matches its Crossref record; 199 of the 200 references it cites were found in a registry or an index.
Dietary Polyphenols and Their Biological Significance
Open accessAbstract
Dietary polyphenols represent a wide variety of compounds that occur in fruits,vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They aremostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins andphenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis,anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascularprotection, improvement of the endothelial function, as well as inhibition of angiogenesisand cell proliferation activity. Most of these biological actions have been attributed to theirintrinsic reducing capabilities. They may also offer indirect protection by activatingendogenous defense systems and by modulating cellular signaling processes such asnuclear factor-kappa B (NF-кB) activation, activator protein-1(AP-1) DNA binding,glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway,mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated proteinkinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocationinto the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers themost recent literature on the subject, and describes the biological mechanisms of action andprotective effects of dietary polyphenols.
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“They exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties [190,191,192,193,197].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]
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“Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects [25,190,193,197,198,199].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]
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1 retracted
LOTITO, S. B., & Frei, B. B. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.033 · Cited by 780
RetractedPolyphenols: Food sources and bioavailability
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Antioxidant properties of phenolic compounds
Rice-Evans, C. A., Miller, N., & Paganga, G. (1997) · Trends in Plant Science · doi:10.1016/s1360-1385(97)01018-2 · Cited by 4,491
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Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · cited 2×
“Bioavailability appears to differ greatly between the various polyphenols, and the most abundant polyphenols in our diet are not necessarily those leading to the highest concentrat ions of active metabolites in target tissues [189].”
BackgroundTannins and Human Health: A Review
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Nrf2–Keap1 defines a physiologically important stress response mechanism
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1 of the 200 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Lotito, 2006, Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?, Free Radic. Biol. Med, 41, 1727, 10.1016/j.freeradbiomed.2006.04.033 · DOI
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Cited by
Sorted by citations
Huang, W.-Y., Cai, Y., & Zhang, Y. (2009) · Nutrition and Cancer · doi:10.1080/01635580903191585 · Cited by 1,012
Endothelial dysfunction — A major mediator of diabetic vascular disease
Sena, C. M., Pereira, A. M., & Seiça, R. M. F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.006 · Cited by 819
Health benefits of polyphenols: A concise review
Rana, A., Samtiya, M., Dhewa, T., Mishra, V., & Aluko, R. E. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14264 · Cited by 840
Potential Health Benefits of Olive Oil and Plant Polyphenols
Gorzynik-Debicka, M., Przychodzeń, P., Cappello, F., Kuban‐Jankowska, A., Marino, A., Knap, N., Woźniak, M., & Górska‐Ponikowska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030686 · Cited by 656
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review
Bahadoran, Z., Mirmiran, P., & Azizi, F. (2013) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-12-43 · Cited by 601
Metadata
- Authors
- Han, X., Shen, T., & Lou, H.
- Affiliations
- Shandong University (CN)
- Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, P. R. China
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2007-09-12
- Volume
- 8
- Issue
- 9
- Pages
- 950-988
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3871896
- OpenAlex
- W2166129369
- Cited by
- 1,081
- References
- 200
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 78 · 2023: 83 · 2022: 81 · 2021: 80 · 2020: 79 · 2019: 78 · 2018: 72 · 2017: 75 · 2016: 60 · 2015: 54 · 2014: 80 · 2013: 52 · 2012: 48
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- dietary polyphenols, flavonoids, catechins, phenolic acids, isoflavones, flavonols, antioxidant activity, anti-inflammatory activity, anticarcinogenic activity, anti-aging, cardioprotection, endothelial function, angiogenesis inhibition, cell proliferation inhibition, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, Nrf2, glutathione synthesis
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