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Dietary Polyphenols and Their Biological Significance
Open accessAbstract
Dietary polyphenols represent a wide variety of compounds that occur in fruits,vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They aremostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins andphenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis,anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascularprotection, improvement of the endothelial function, as well as inhibition of angiogenesisand cell proliferation activity. Most of these biological actions have been attributed to theirintrinsic reducing capabilities. They may also offer indirect protection by activatingendogenous defense systems and by modulating cellular signaling processes such asnuclear factor-kappa B (NF-кB) activation, activator protein-1(AP-1) DNA binding,glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway,mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated proteinkinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocationinto the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers themost recent literature on the subject, and describes the biological mechanisms of action andprotective effects of dietary polyphenols.
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“They exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties [190,191,192,193,197].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]
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“Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects [25,190,193,197,198,199].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]
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Metadata
- Authors
- Han, X., Shen, T., & Lou, H.
- Affiliations
- Shandong University (CN)
- Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, P. R. China
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2007-09-12
- Volume
- 8
- Issue
- 9
- Pages
- 950-988
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3871896
- OpenAlex
- W2166129369
- Cited by
- 1,081
- References
- 200
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 78 · 2023: 83 · 2022: 81 · 2021: 80 · 2020: 79 · 2019: 78 · 2018: 72 · 2017: 75 · 2016: 60 · 2015: 54 · 2014: 80 · 2013: 52 · 2012: 48
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- dietary polyphenols, flavonoids, catechins, phenolic acids, isoflavones, flavonols, antioxidant activity, anti-inflammatory activity, anticarcinogenic activity, anti-aging, cardioprotection, endothelial function, angiogenesis inhibition, cell proliferation inhibition, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, Nrf2, glutathione synthesis
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