Dietary Polyphenols and Their Biological Significance

Polyphenols: Food sources and bioavailability

Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175

Antioxidant properties of phenolic compounds

Rice-Evans, C. A., Miller, N., & Paganga, G. (1997) · Trends in Plant Science · doi:10.1016/s1360-1385(97)01018-2 · Cited by 4,491

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · cited 2×

Tannins and Human Health: A Review

Chung, K.-T., Wong, T. Y., Wei, C.-I., Huang, Y.-W., & Lin, Y. (1998) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408699891274273 · Cited by 1,996

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725 · cited 1×

Curcumin: The story so far

Sharma, R. A., Gescher, A. J., & Steward, W. P. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.05.009 · Cited by 1,701

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

Hayes, J. D., & McLellan, L. I. (1999) · Free Radical Research · doi:10.1080/10715769900300851 · Cited by 1,528

Free Radicals as Mediators of Tissue Injury and Disease

Kehrer, J. P. (1993) · Critical Reviews in Toxicology · doi:10.3109/10408449309104073 · Cited by 1,460

Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes

Masella, R., Benedetto, R. D., Varı́, R., Filesi, C., & Giovannini, C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.05.013 · Cited by 1,109

Regulation of inflammation and redox signaling by dietary polyphenols

Rahman, I., Biswas, S. K., & Kirkham, P. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.004 · Cited by 1,003

Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants

Sakihama, Y. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00196-8 · Cited by 895

Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells

Subbaramaiah, K., Chung, W. J., Michaluart, P., TELANG, N. T., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J. M., & Dannenberg, A. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21875 · Cited by 786

Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man

Hollman, P. C. H., van Trijp, J. M. P., Buysman, M. N. C. P., van der Gaag, M. S., Mengelers, M. J. B., de Vries, J. H. M., & Katan, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01367-7 · Cited by 782

Resveratrol stimulates AMP kinase activity in neurons

Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723

New concepts in reactive oxygen species and cardiovascular reperfusion physiology

Becker, L. C. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.025 · Cited by 703

Different Polyphenolic Components of Soft Fruits Inhibit α-Amylase and α-Glucosidase

McDougall, G. J., Shpiro, F., Dobson, P. P., Smith, P., Blake, A., & Stewart, D. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0489926 · Cited by 687

Curcumin labels amyloid pathology in vivo , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

García-Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., & Bacskai, B. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04613.x · Cited by 676

Olive Oil and Red Wine Antioxidant Polyphenols Inhibit Endothelial Activation: Antiatherogenic Properties of Mediterranean Diet Phytochemicals

Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M., Scoditti, E., Storelli, C., Visioli, F., Distante, A., & De Caterina, R. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000062884.69432.a0 · Cited by 640

Curcumin Potentiates Antitumor Activity of Gemcitabine in an Orthotopic Model of Pancreatic Cancer through Suppression of Proliferation, Angiogenesis, and Inhibition of Nuclear Factor-κB–Regulated Gene Products

Kunnumakkara, A. B., Guha, S., Krishnan, S., Diagaradjane, P., Gelovani, J. G., & Aggarwal, B. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4257 · Cited by 588

Invited Review Free Radicals in Disease Processes: A Compilation of Cause and Consequence

Gutteridge, J. M. C., & Halliwell, B. B. (1993) · Free Radical Research Communications · doi:10.3109/10715769309111598 · Cited by 571

Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics

Galati, G. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00198-1 · Cited by 530

Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways

Aoki, H., Takada, Y., Kondo, S., Sawaya, R. A., Aggarwal, B. B., & Kondo, Y. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033167 · Cited by 523

Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa

Holt, R. R., Lazarus, S. A., Sullards, M. C., Zhu, Q. Y., Schramm, D. D., Hammerstone, J. F., Fraga, C. G., Schmitz, H. H., & Keen, C. L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.798 · Cited by 522

Suppression of nitric oxide synthase and the down‐regulation of the activation of NFκB in macrophages by resveratrol

Tsai, S., Lin‐Shiau, S., & Lin, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702357 · Cited by 511

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

Bharti, A. C., Donato, N. J., & Aggarwal, B. B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3863 · Cited by 511

Plasma Kinetics and Urinary Excretion of the Flavanones Naringenin and Hesperetin in Humans after Ingestion of Orange Juice and Grapefruit Juice

Erlund, I., Meririnne, E., Alfthan, G., & Aro, A. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.235 · Cited by 505

Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin

Tanigawa, S., Fujii, M., & Hou, D.-X. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.017 · Cited by 487

Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice

Manach, C., Morand, C., Gil‐Izquierdo, Á., Bouteloup‐Demange, C., & Rémésy, C. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601547 · Cited by 459

Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines.

Joe, A. K., Liu, H., Suzui, M., Vural, M. E., Xiao, D., & Weinstein, I. B. (2002) · PubMed · Cited by 455

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice

Seeram, N. P., Lee, R., & Heber, D. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.04.029 · Cited by 454

Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals

Zheng, J., & Ramirez, V. D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703397 · Cited by 453

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

Anto, R. J. (2002) · Carcinogenesis · doi:10.1093/carcin/23.1.143 · Cited by 430

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

Chen, C.-Y., Jang, J.-H., Li, M.-H., & Surh, Y.-J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.237 · Cited by 428

Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action

Levites, Y., Amit, T., Youdim, M. B. H., & Mandel, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202832200 · Cited by 417

The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids

Rietjens, I. M. C. M., Boersma, M. G., de Haan, L., Spenkelink, B., Awad, H. M., Cnubben, N. H. P., van Zanden, J. J., van der Woude, H., Alink, G. M., & Koeman, J. H. (2002) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(02)00003-0 · Cited by 415

Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity

Casper, R. F., Quesne, M., Rogers, I. M., Shirota, T., Jolivet, A., Milgröm, E., & Savouret, J. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12541-2 · Cited by 414

Olive oil and the cardiovascular system

Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 408

Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter

Myhrstad, M. C. W., Carlsen, H., Nordström, O., Blomhoff, R., & Moskaug, J. Ø. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00812-7 · Cited by 408

Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death

Chen, C., Yu, R., Owuor, E. D., & Kong, A.-N. T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975249 · Cited by 403

Nutritional approaches to combat oxidative stress in Alzheimer’s disease

Butterfield, D. A., Castegna, A., Pocernich, C. B., Drake, J., Scapagnini, G., & Calabrese, V. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00205-x · Cited by 402

Effects of Dosing Condition on the Oral Bioavailability of Green Tea Catechins after Single-Dose Administration of Polyphenon E in Healthy Individuals

Chow, H.-H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., & Alberts, D. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2549 · Cited by 400

Green Tea Polyphenols Inhibit the Sodium-Dependent Glucose Transporter of Intestinal Epithelial Cells by a Competitive Mechanism

Kobayashi, Y., Suzuki, M. M., Satsu, H., Arai, S., Hara, Y., Suzuki, K., Miyamoto, Y., & Shimizu, M. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0006832 · Cited by 386

Olive oil phenolics are dose‐dependently absorbed in humans

Visioli, F., Galli, C., Bornet, F. R. J., Mattei, A., Patelli, R., Galli, G., & Caruso, D. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01216-3 · Cited by 375

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

Schroeter, H., Spencer, J. P. E., Rice-Evans, C. A., & WILLIAMS, R. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580547 · Cited by 373

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease

Hartman, R. E., Shah, A., Fagan, A. M., Schwetye, K. E., Parsadanian, M., Schulman, R. N., Finn, M. B., & Holtzman, D. M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.006 · Cited by 366

Suppression of the Nuclear Factor‐κB Activation Pathway by Spice‐Derived Phytochemicals: Reasoning for Seasoning

Aggarwal, B. B., & Shishodia, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.054 · Cited by 364

Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil

Petroni, A., Blasevich, M., Salami, M., Papini, N., Montedoro, G. F., & Galli, C. (1995) · Thrombosis Research · doi:10.1016/0049-3848(95)00043-7 · Cited by 362

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms

Donnelly, L., Newton, R. C., Kennedy, G. E., Fenwick, P. S., Leung, R. H. F., Ito, K., Russell, R. E. K., & Barnes, P. J. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00110.2004 · Cited by 362

Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages

Pan, M., Lin‐Shiau, S., & Lin, J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00489-5 · Cited by 356

Dietary polyphenols decrease glucose uptake by human intestinal Caco‐2 cells

Johnston, K. L., Sharp, P., Clifford, M. N., & Morgan, L. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.099 · Cited by 350

Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability

Spencer, J. P. E., Rice-Evans, C. A., & Williams, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305063200 · Cited by 350

Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis

Camacho‐Barquero, L., Villegas, I., Sánchez-Calvo, J. M., Talero, E., Sánchez‐Fidalgo, S., Motilva, V., & Alarcón‐de‐la‐Lastra, C. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.11.006 · Cited by 349

Metabolism of dietary procyanidins in rats

Gonthier, M., Donovan, J. L., Texier, O., Felgines, C., Rémésy, C., & Scalbert, A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00394-0 · Cited by 345

The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury

Ray, P. S., Maulik, G., Cordis, G. A., Bertelli, A. A. E., Bertelli, A., & Das, D. K. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00063-5 · Cited by 343

Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement

Henning, S. M., Niu, Y., Lee, N. H., Thames, G., Minutti, R. R., Wang, H., Go, V. L. W., & Heber, D. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1558 · Cited by 342

Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil

la Puerta, R. D., Gutierrez, V. R., & Hoult, J. R. S. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00320-7 · Cited by 336

A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

Lorenz, M., Weßler, S., Follmann, E., Michaelis, W., Düsterhöft, T., Baumann, G., Stangl, K., & Stangl, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309114200 · Cited by 334

Effects of curcumin on retinal oxidative stress and inflammation in diabetes

Kowluru, R. A., & Kanwar, M. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-8 · Cited by 332

Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.

Bhat, K., Lantvit, D. D., Christov, K. T., Mehta, R. G., Moon, R. C., & Pezzuto, J. M. (2001) · PubMed · Cited by 330

Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract

Rangkadilok, N., Sitthimonchai, S., Worasuttayangkurn, L., Mahidol, C., Ruchirawat, M., & Satayavivad, J. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.08.022 · Cited by 327

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00221-2 · Cited by 319

Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells.

Ahmad, N., Adhami, V. M., Afaq, F., Feyes, D. K., & Mukhtar, H. (2001) · PubMed · Cited by 318

Curcumin Suppresses Janus Kinase-STAT Inflammatory Signaling through Activation of Src Homology 2 Domain-Containing Tyrosine Phosphatase 2 in Brain Microglia

Kim, H. Y., Park, E. J., Joe, E.-H., & Jou, I. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6072 · Cited by 314

Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.

Gerritsen, M. E., Carley, W. W., Ranges, G. E., Shen, C. P., Phan, S. A., Ligon, G. F., & Perry, C. A. (1995) · Europe PMC (PubMed Central) · Cited by 305

Quercetin, a Flavonoid Antioxidant, Prevents and Protects against Ethanol-Induced Oxidative Stress in Mouse Liver

Molina, M. F., Sánchez-Reus, I., Peinado, I. I., & Benedı́, J. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1398 · Cited by 297

Hydroxytyrosol Disposition in Humans

Miró‐Casas, E., Covas, M.-I., Farré, M., Fitó, M., Ortuño, J., Weinbrenner, T., Roset, P. N., & de la Torre, R. (2003) · Clinical Chemistry · doi:10.1373/49.6.945 · Cited by 293

Vascular effects of wine polyphenols

Dell’Agli, M. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.019 · Cited by 276

Flavonoid Inhibition of Sodium-dependent Vitamin C Transporter 1 (SVCT1) and Glucose Transporter Isoform 2 (GLUT2), Intestinal Transporters for Vitamin C and Glucose

Song, J., Kwon, O., Chen, S., Daruwala, R., Eck, P., Park, J. B., & Levine, M. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110496200 · Cited by 262

Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues11Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase; EGCG, (-)-epigallocatechin-3-gallate; EGC, (-)-epigallocatechin; ECG, (-)-epicatechin-3-gallate; EC, (-)-epicatechin; TF, theaflavin; TF3-G, theaflavin 3-gallate; TF3′-G, theaflavin 3′-gallate; TFdiG, theaflavin 3,3′-digallate; PGE2, prostaglandin E2; HETE, hydroxyeicosatetraenoic acid; HHT, 12-hydroxyheptadecatrienoic acid; and TBX, thromboxane.

Hong, J., Smith, T. J., Ho, C., August, D. A., & Yang, C. S. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00767-5 · Cited by 262

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide

Alía, M., Ramos, S., Mateos, R., Granado‐Serrano, A. B., Bravo, L., & Goya, L. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.07.014 · Cited by 258

Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice

Bub, A., Watzl, B., Heeb, D., Rechkemmer, G., & Briviba, K. (2001) · European Journal of Nutrition · doi:10.1007/s003940170011 · Cited by 254

Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro

Gonthier, M., Rémésy, C., Scalbert, A., Cheynier, V., Souquet, J., Poutanen, K., & Aura, A. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.084 · Cited by 247

(+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine

Bell, J. R., Donovan, J. L., Wong, R., Waterhouse, A. L., German, J. B., Walzem, R. L., & Kasim-Karakas, S. E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.103 · Cited by 244

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

Schroeter, H., Spencer, J. P. E., Rice-Evans, C. A., et al. (2001) · Biochemical Journal · doi:10.1042/bj3580547 · Cited by 243

Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures

Mercer, L. D., Kelly, B. L., Horne, M. K., & Beart, P. M. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.09.018 · Cited by 241

Inhibition of angiotensin converting enzyme (ACE) activity by flavan‐3‐ols and procyanidins

Actis‐Goretta, L., Ottaviani, J. I., Keen, C. L., & Fraga, C. G. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01355-3 · Cited by 241

Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism

Gouédard, C., Barouki, R., & Morel, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5209-5222.2004 · Cited by 238

Epigallocatechin Gallate, a Green Tea Polyphenol, Mediates NO-dependent Vasodilation Using Signaling Pathways in Vascular Endothelium Requiring Reactive Oxygen Species and Fyn

Kim, J., Formoso, G., Li, Y., Potenza, M. A., Marasciulo, F. L., Montagnani, M., & Quon, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609725200 · Cited by 237

Downregulation of the Cyclin D1/Cdk4 Complex Occurs during Resveratrol-Induced Cell Cycle Arrest in Colon Cancer Cell Lines

Wolter, F., Akoglu, B., Clausnitzer, A., & Stein, J. M. (2001) · Journal of Nutrition · doi:10.1093/jn/131.8.2197 · Cited by 235

Inhibition of Aryl Hydrocarbon-Induced Cytochrome P-450 1A1 Enzyme Activity and CYP1A1 Expression by Resveratrol

Ciolino, H. P., & Yeh, G. C. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12538-2 · Cited by 233

The fate of olive oil polyphenols in the gastrointestinal tract: Implications of gastric and colonic microflora-dependent biotransformation

Corona, G., Tzounis, X., Dessì, M., Deiana, M., Debnam, E. S., Visioli, F., & Spencer, J. P. E. (2006) · Free Radical Research · doi:10.1080/10715760500373000 · Cited by 231

Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds.

Fujisawa, S., Atsumi, T., Ishihara, M., & Kadoma, Y. (2004) · PubMed · Cited by 229

Inhibition of homodimerization of Toll-like receptor 4 by curcumin

Youn, H. S., Saitoh, S. I., Miyake, K., & Hwang, D. H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.022 · Cited by 227

Interaction of the breast cancer resistance protein with plant polyphenols

Cooray, H. C., Janvilisri, T., van Veen, H. W., Hladky, S. B., & Barrand, M. A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.040 · Cited by 226

Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells

Schramm, D. D., Wang, J. F., Holt, R. R., Ensunsa, J. L., Gonsalves, J. L., Lazarus, S. A., Schmitz, H. H., German, J. B., & Keen, C. L. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.1.36 · Cited by 224

Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice

Sharma, S. D., Meeran, S. M., & Katiyar, S. K. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0661 · Cited by 219

Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis

Fabiani, R., De Bartolomeo, A., Rosignoli, P., Servili, M., Montedoro, G. F., & Morozzi, G. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200208000-00006 · Cited by 210

Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells

Collett, G. P. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh233 · Cited by 209

Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.

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Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults

Okawara, M., Katsuki, H., Kurimoto, E., Shibata, H., Kume, T., & Akaike, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.003 · Cited by 202

Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor

Kaga, S., Zhan, L., MATSUMOTO, M., & Maulik, N. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.08.003 · Cited by 199

Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN

Sato, M., Bagchi, D., Tósaki, Á., & Das, D. K. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00626-8 · Cited by 198

Dietary soy-derived isoflavone phytoestrogens

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The In Vivo Fate of Hydroxytyrosol and Tyrosol, Antioxidant Phenolic Constituents of Olive Oil, after Intravenous and Oral Dosing of Labeled Compounds to Rats

Tuck, K. L., Freeman, M. P., Hayball, P. J., Stretch, G. L., & Stupans, I. (2001) · Journal of Nutrition · doi:10.1093/jn/131.7.1993 · Cited by 184

Grape Seed Polyphenols Protect Cardiac Cells from Apoptosis via Induction of Endogenous Antioxidant Enzymes

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Curcumin Suppresses Lipopolysaccharide-Induced Cyclooxygenase-2 Expression by Inhibiting Activator Protein 1 and Nuclear Factor κB Bindings in BV2 Microglial Cells

Kang, G., Kong, P., Yuh, Y.-J., Lim, S.-Y., Yim, S., Chun, W., & Kim, S. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.325 · Cited by 181

The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells

Nair, M., Kandaswami, C. C., Mahajan, S. D., Chadha, K. C., Chawda, R. P., Nair, H. N., Kumar, N. M., Nair, R. E., & Schwartz, S. A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00328-2 · Cited by 180

The inhibitory effects of hull polysaccharides and tannins of field beans (Vicia faba L.) on the digestion of amino acids, starch and lipid and on digestive enzyme activities in young chicks

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Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products

Appiah‐Opong, R., Commandeur, J. N. M., van Vugt-Lussenburg, B., & Vermeulen, N. P. E. (2007) · Toxicology · doi:10.1016/j.tox.2007.03.007 · Cited by 178

Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells.

Lee, L.-T., Huang, Y.-T., Hwang, J.-J., Lee, P. H., Ke, F., Nair, M. P. N., Kanadaswam, C., & Lee, M. (2002) · PubMed · Cited by 176

Hydroxytyrosol-Rich Olive Mill Wastewater Extract Protects Brain Cells in Vitro and ex Vivo

Schaffer, S., Podstawa, M., Visioli, F., Bogani, P., Müller, W. E., & Eckert, G. P. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0703710 · Cited by 175

Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells

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Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells

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SIRT1 stimulation by polyphenols is affected by their stability and metabolism

de Boer, V. C. J., de Goffau, M. C., Arts, I. C. W., Hollman, P. C. H., & Keijer, J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.02.007 · Cited by 168

Absorption and antioxidant effects of quercetin from onions, in man

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Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells

Kuo, P., Chiang, L., & Lin, C. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02177-x · Cited by 167

Absorption and Excretion of Black Currant Anthocyanins in Humans and Watanabe Heritable Hyperlipidemic Rabbits

Nielsen, I. L. F., Dragsted, L. O., Ravn‐Haren, G., Freese, R., & Rasmussen, S. E. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025947u · Cited by 165

Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes

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Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease

Widlansky, M. E., Duffy, S. J., Hamburg, N. M., Gokce, N., Warden, B. A., Wiseman, S., Keaney, J. F., Frei, B., & Vita, J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.013 · Cited by 162

Polyphenol Constituents from Salacia Species: Quantitative Analysis of Mangiferin with α-Glucosidase and Aldose Reductase Inhibitory Activities

Yoshikawa, M., Nishida, N., Shimoda, H., Takada, M., Kawahara, Y., & Matsuda, H. (2001) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.121.371 · Cited by 157

Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals

Henning, S. M., Niu, Y., Liu, Y., Lee, N. H., Hara, Y., Thames, G., Minutti, R. R., Carpenter, C. L., Wang, H., & Heber, D. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.003 · Cited by 155

Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element

Nishinaka, T., Ichijo, Y., Ito, M., Kimura, S., Katsuyama, M., Iwata, K., Miura, T., Terada, T., & Yabe‐Nishimura, C. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.03.011 · Cited by 153

Flavones Mitigate Tumor Necrosis Factor-α-Induced Adhesion Molecule Upregulation in Cultured Human Endothelial Cells: Role of Nuclear Factor-κB

Choi, J.-S., Choi, Y. J., Park, S.-H., Kang, J.-S., & Kang, Y. (2004) · Journal of Nutrition · doi:10.1093/jn/134.5.1013 · Cited by 152

Resveratrol prevents fibrosis, NF‐κB activation and TGF‐β increases induced by chronic CCl4 treatment in rats

Chávez, E., Reyes‐Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., & Muriel, P. (2007) · Journal of Applied Toxicology · doi:10.1002/jat.1249 · Cited by 152

Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production

Martin, S., Andriambeloson, E., Takeda, K., & Andriantsitohaina, R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704603 · Cited by 150

Resveratrol modulates the phosphoinositide 3‐kinase pathway through an estrogen receptor α‐dependent mechanism: Relevance in cell proliferation

Pozo‐Guisado, E., Lorenzo‐Benayas, M. J., & Fernández‐Salguero, P. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.11720 · Cited by 150

Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skin

Jang, M., & Pezzuto, J. M. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00250-x · Cited by 150

Structural and Functional Characterization of Polyphenols Isolated from Acerola ( Malpighia emarginata DC.) Fruit

Hanamura, T., Hagiwara, T., & Kawagishi, H. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.280 · Cited by 145

Resveratrol Inhibits IL‐1β–Induced Stimulation of Caspase‐3 and Cleavage of PARP in Human Articular Chondrocytes in Vitro

Shakibaei, M., John, T., Seifarth, C., & Mobasheri, A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.060 · Cited by 145

Urinary excretion of olive oil phenols and their metabolites in humans

Caruso, D., Visioli, F., Patelli, R., Galli, C., & Galli, G. (2001) · Metabolism · doi:10.1053/meta.2001.28073 · Cited by 143

Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion

Manna, C., Migliardi, V., Golino, P., Scognamiglio, A., Galletti, P., Massimo Chiariello, A., & Zappia, V. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.12.010 · Cited by 142

The Isoflavone Equol Mediates Rapid Vascular Relaxation

Joy, S., Siow, R. C. M., Rowlands, D. J., Becker, M., Wyatt, A. W., Aaronson, P. I., Coen, C. W., Kalló, I., Jacob, R., & Mann, G. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602803200 · Cited by 141

Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3

Cadenas, S., & Barja, G. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00019-2 · Cited by 139

Anti-apoptotic activity of caffeic acid, ellagic acid and ferulic acid in normal human peripheral blood mononuclear cells: A Bcl-2 independent mechanism

KHANDUJA, K. L., Avti, P., Kumar, S., Mittal, N., Sohi, K. K., & Pathak, C. M. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.12.017 · Cited by 139

Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract

Khanna, S. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00544-5 · Cited by 138

Polyphenols of Cocoa: Inhibition of Mammalian 15-Lipoxygenase

SCHEWE, T., Sadik, C. D., Klotz, L., Yoshimoto, T., Kühn, H., & Sies, H. (2001) · Biological Chemistry · doi:10.1515/bc.2001.204 · Cited by 137

Inhibition of Arachidonate Lipoxygenase Activities by 2-(3,4-Dihydroxyphenyl)ethanol, a Phenolic Compound from Olives

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Enhancement of Glutathione and γ-Glutamylcysteine Synthetase, the Rate Limiting Enzyme of Glutathione Synthesis, by Chemoprotective Plant-Derived Food and Beverage Components in the Human Hepatoma Cell Line HepG2

Scharf, G., Prustomersky, S., Knasmüller, S., Schulte‐Hermann, R., & Huber, W. W. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4501_9 · Cited by 127

Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin

Valerio, L. G., Kepa, J. K., Pickwell, G. V., & Quattrochi, L. C. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(00)00302-7 · Cited by 124

Structural Characterization of the Metabolites of Hydroxytyrosol, the Principal Phenolic Component in Olive Oil, in Rats

Tuck, K. L., Hayball, P. J., & Stupans, I. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011264n · Cited by 123

The effect of cocoa procyanidins on the transcription and secretion of interleukin 1β in peripheral blood mononuclear cells

Mao, T. K., Powell, J. J., de Water, J. V., Keen, C. L., Schmitz, H. H., Hammerstone, J. F., & Gershwin, M. E. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00449-5 · Cited by 122

Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression

Dedoussis, G. V., Kaliora, A. C., Psarras, S., Chiou, A., Mylona, A., Papadopoulos, N. G., & Andrikopoulos, N. K. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.02.011 · Cited by 122

Grape Polyphenol Resveratrol and the Related Molecule 4-Hydroxystilbene Induce Growth Inhibition, Apoptosis, S-Phase Arrest, and Upregulation of Cyclins A, E, and B1 in Human SK-Mel-28 Melanoma Cells

Larrosa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030073c · Cited by 120

Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells.

Bhat, K., & Pezzuto, J. M. (2001) · PubMed · Cited by 119

Dietary unripe apple polyphenol inhibits the development of food allergies in murine models

Akiyama, H., Sato, Y., Watanabe, T., Nagaoka, M. H., Yoshioka, Y., Shoji, T., Kanda, T., Yamada, K., Totsuka, M., Teshima, R., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.019 · Cited by 116

Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds

Kluth�, D., Banning, A., Paur, I., Blomhoff, R., & Brigelius‐Flohé, R. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.028 · Cited by 116

Epigallocatechin-3-gallate suppresses NF-κB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells

Kim, S.-J., Jeong, H.-J., Lee, K.-M., Myung, N.-Y., An, N.-H., Mo Yang, W., Kyu Park, S., Lee, H.-J., Hong, S.-H., Kim, H.-M., et al. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.11.001 · Cited by 116

Evaluation of polyphenol bioavailability in rat small intestine

Carbonaro, M., Grant, G., & Pusztai, A. J. (2001) · European Journal of Nutrition · doi:10.1007/s003940170020 · Cited by 115

Inhibition of protein kinase C by resveratrol

Slater, S. J., Seiz, J. L., Cook, A. C., Stagliano, B. A., & Buzas, C. J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00214-4 · Cited by 115

Inhibition of Peroxynitrite‐Mediated Oxidation of Dopamine by Flavonoid and Phenolic Antioxidants and Their Structural Relationships

Kerry, N. L., & Rice-Evans, C. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730247.x · Cited by 113

Polyphenols restore endothelial function in DOCA-salt hypertension: Role of endothelin-1 and NADPH oxidase

Jiménez, R., López-Sepúlveda, R., Kadmiri, M., Romero, M., Vera, R., Sánchez, M., Vargas, F., O’Valle, F., Zarzuelo, A., Dueñas, M., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.007 · Cited by 109

Red Wine Polyphenols Inhibit Vascular Smooth Muscle Cell Migration Through Two Distinct Signaling Pathways

Iijima, K., Yoshizumi, M., Hashimoto, M., Akishita, M., Kozaki, K., Ako, J., Watanabe, T., Ohike, Y., Son, B., Yu, J. H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000016349.36385.fb · Cited by 106

Curcumin Prevents Tumor-induced T Cell Apoptosis through Stat-5a-mediated Bcl-2 Induction

Bhattacharyya, S., Mandal, D. P., Saha, B., Sen, G. S., Das, T., & Sa, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608189200 · Cited by 105

Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells

Huang, J., de Paulis, T., & May, J. M. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.07.002 · Cited by 101

Accelerated communication: Effects of flavonoids on Naja Naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice

Gil, B., Sanz, M., Ferrándiz, M. L., Bustos, G., Payá, M., Gunasegaran, R., & Alcaraz, M. J. (1994) · Life Sciences · doi:10.1016/0024-3205(94)90021-3 · Cited by 99

A Novel Proanthocyanidin IH636 Grape Seed Extract Increases in Vivo Bcl-Xl Expression and Prevents Acetaminophen-Induced Programmed and Unprogrammed Cell Death in Mouse Liver

Ray, S. D., Kumar, M. A. S., & Bagchi, D. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1333 · Cited by 99

Epigallocatechin gallate attenuates adhesion and migration of CD8+ T cells by binding to CD11b

Kawai, K., Tsuno, N. H., Kitayama, J., Okaji, Y., Yazawa, K., Asakage, M., Hori, N., Watanabe, T., Takahashi, K., & Nagawa, H. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.02.044 · Cited by 99

Hypocholesterolemic Effects of Phenolic Extracts and Purified Hydroxytyrosol Recovered from Olive Mill Wastewater in Rats Fed a Cholesterol-Rich Diet

Fki, I., Sahnoun, Z., & Sayadi, S. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0623586 · Cited by 97

Quantitative structure–activity relationships in prooxidant cytotoxicity of polyphenols: Role of potential of phenoxyl radical/phenol redox couple

Nemeikaitė-Čėnienė, A., Imbrasaitė, A., Sergedienė, E., & Čėnas, N. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.07.002 · Cited by 96

(-)Epigallocatechin Gallate and Quercetin Enhance Survival Signaling in Response to Oxidant-Induced Human Endothelial Apoptosis

Choi, Y. J., Jeong, Y.-J., Lee, Y., Kwon, H., & Kang, Y. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.707 · Cited by 91

Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis

Poussier, B., Cordova, A. C., Becquemin, J., & Sumpio, B. E. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.08.014 · Cited by 91

Activin, a Grape Seed-derived Proanthocyanidin Extract, Reduces Plasma Levels of Oxidative Stress and Adhesion Molecules (ICAM-1, VCAM-1 and E-selectin) in Systemic Sclerosis

Kalfin, R. E., Righi, A., Rosso, A. D., Bagchi, D., Generini, S., Guiducci, S., Matucci‐Cerinic, M., & Das, D. K. (2002) · Free Radical Research · doi:10.1080/1071576021000005249 · Cited by 90

Regulation of inducible adhesion molecule expression in human endothelial cells by grape seed proanthocyanidin extract

Sen, C. K., & Bagchi, D. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1011053300727 · Cited by 86

Effect of resveratrol on proliferation and telomerase activity of human colon cancer cells in vitro.

Fuggetta, M. P., Lanzilli, G., Tricarico, M., Cottarelli, A., Falchetti, R., Ravagnan, G., & Bonmassar, E. (2006) · PubMed · Cited by 86

Antioxidant Therapeutic Targets in COPD

Rahman, I., & Kilty, I. (2006) · Current Drug Targets · doi:10.2174/138945006777435254 · Cited by 86

Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki‐Cdk‐cyclin cascade, and caspase‐3 activation via loss of mitochondrial membrane potential

Meeran, S. M., & Katiyar, S. K. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00542.x · Cited by 85

A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes

Léger, C., Carbonneau, M. A., Michel, F., Mas, E., Monnier, L., Cristol, J., & Descomps, B. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602133 · Cited by 85

Red Wine Polyphenolic Compounds Inhibit Vascular Endothelial Growth Factor Expression in Vascular Smooth Muscle Cells by Preventing the Activation of the p38 Mitogen-Activated Protein Kinase Pathway

Oak, M., Chataigneau, M., Keravis, T. M., Chataigneau, T., Beretz, A., Andriantsitohaina, R., Stoclet, J., Chang, S.-J., & Schini‐Kerth, V. B. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000070101.70534.38 · Cited by 85

Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease

Meeteren, M. E. V., Hendriks, J. J. A., Dijkstra, C. D., & van Tol, E. A. F. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.10.018 · Cited by 84

Involvement of the Retinoblastoma (pRb)–E2F/DP Pathway during Antiproliferative Effects of Resveratrol in Human Epidermoid Carcinoma (A431) Cells

Adhami, V. M., Afaq, F., & Ahmad, N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5819 · Cited by 82

Cyanidin‐3‐glucoside regulates phosphorylation of endothelial nitric oxide synthase

Xu, J., Ikeda, K., & Yamori, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.027 · Cited by 81

Red wine polyphenols induce EDHF‐mediated relaxations in porcine coronary arteries through the redox‐sensitive activation of the PI3‐kinase/Akt pathway

Ndiaye, M., Chataigneau, T., Chataigneau, M., & Schini‐Kerth, V. B. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705774 · Cited by 80

Resveratrol inhibits phorbol ester‐induced cyclooxygenase‐2 expression in mouse skin: MAPKs and AP‐1 as potential molecular targets

Kundu, J. K., Chun, K., Kim, S. O., & Surh, Y. (2004) · BioFactors · doi:10.1002/biof.552210108 · Cited by 79

Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals

Álvarez, P., Alvarado, C., Puerto, M., Schlumberger, A., Jiménez, L., & la Fuente, M. D. (2006) · Nutrition · doi:10.1016/j.nut.2005.12.012 · Cited by 78

Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride

Kuzu, N., Metin, K., Dağlı, A. F., Akdemir, F., Orhan, C., Yalnız, M., Özercan, İ. H., Şahin, K., & Bahçecioğlu, İ. H. (2007) · Mediators of Inflammation · doi:10.1155/2007/36381 · Cited by 77

Resveratrol, a natural ingredient of grape skin: Antiarrhythmic efficacy and ionic mechanisms

Zhang, Y., Liu, Y., Wang, T., Li, B., Li, H., Wang, Z., & Yang, B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.124 · Cited by 75

Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells

Otake, Y., Nolan, A. L., Walle, U. K., & Walle, T. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00073-x · Cited by 72

Red Wine Polyphenolic Compounds Strongly Inhibit Pro-Matrix Metalloproteinase-2 Expression and Its Activation in Response to Thrombin via Direct Inhibition of Membrane Type 1–Matrix Metalloproteinase in Vascular Smooth Muscle Cells

Oak, M., Bedoui, J. E., Anglard, P., & Schini‐Kerth, V. B. (2004) · Circulation · doi:10.1161/01.cir.0000142617.52881.f4 · Cited by 71

Modulation of ceramide-induced NF-κB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidants

Nardini, M., Leonardi, F., Scaccini, C., & Virgili, F. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00515-3 · Cited by 70

Scavenging of peroxynitrite by a phenolic/peroxidase system prevents oxidative damage to DNA1

Grace, S. C., Salgo, M. G., & Pryor, W. A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00298-1 · Cited by 69

Inhibition by epigallocatechin gallate of CoCl2-induced apoptosis in rat PC12 cells

Jung, J., Mo, H.-C., Yang, K.-H., Jeong, Y.-J., Yoo, H. G., Choi, N., Oh, W., Oh, H.-K., Kim, S.-H., Lee, J. H., et al. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.033 · Cited by 67

Epigallocatechin gallate induces apoptosis of monocytes

Kawai, K., Tsuno, N. H., Kitayama, J., Okaji, Y., Yazawa, K., Asakage, M., Sasaki, S., Watanabe, T., Takahashi, K., & Nagawa, H. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.10.005 · Cited by 62

In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1

Schwarz, D., & Roots, I. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00435-2 · Cited by 58

Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells

Khan, N. Q., Lees, D. M., Douthwaite, J. A., CARRIER, M. J., & Corder, R. (2002) · Clinical Science · doi:10.1042/cs103s072s · Cited by 58

Grape seed extract proanthocyanidins downregulate HIV- 1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells

Nair, M., Kandaswami, C. C., Mahajan, S. D., Nair, H. N., Chawda, R. P., Shanahan, T., & Schwartz, S. A. (2002) · Biological Research · doi:10.4067/s0716-97602002000300016 · Cited by 52

Antimycoplasmal Activity of Hydroxytyrosol

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Neuroprotective Effects of Natural Products: Interaction with Intracellular Kinases, Amyloid Peptides and a Possible Role for Transthyretin

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Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell–ECM interaction

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Effects of curcumin in treatment of experimental pulmonary fibrosis: A comparison with hydrocortisone

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Non-Nutritive Bioactive Food Constituents of Plants: Bioavailability of Flavonoids

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Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes

Cullen, J. P., Morrow, D. J., Jin, Y., Sweeney, N. V. O., Sitzmann, J. V., Cahill, P. A., & Redmond, E. M. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.03.039 · Cited by 40

Resveratrol inhibits matrix metalloproteinase-9 transcription in U937 cells.

Li, Y.-T., Shen, F., Liu, B.-H., & Cheng, G.-F. (2003) · PubMed · Cited by 39

Rapid high-performance liquid chromatography–electrospray ionization tandem mass spectrometry method for qualitative and quantitative analysis of virgin olive oil phenolic metabolites in human low-density lipoproteins

de la Torre‐Carbot, K., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Covas, M., Casals, I., & López‐Sabater, M. C. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.03.022 · Cited by 38

Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7β-hydroxycholesterol to 7-ketocholesterol ratio

Steffen, Y., Wiswedel, I., Peter, D., SCHEWE, T., & Sies, H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.06.027 · Cited by 37

Effect of green tea polyphenols on angiogenesis induced by an angiogenin-like protein

Maiti, T. K., Chatterjee, J., & Dasgupta, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01338-x · Cited by 34

Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: Correlated with NO–cGMP signaling pathway

Wang, S., Wang, X., Yan, J., Xie, X., Fan, F., Zhou, X., Han, L., & Chen, J.-Z. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.023 · Cited by 33

Effect of the phytoestrogen, genistein‐8‐C‐glucoside, on Chinese hamster ovary cells in vitro

Rucinska, A., Kirko, S., & Gabryelak, T. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.05.012 · Cited by 29

Inhibition of nitrobenzene-induced DNA and hemoglobin adductions by dietary constituents

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In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase

Sbarra, V., Ristorcelli, E., Petit‐Thévenin, J. L., Teissèdre, P., Lombardo, D., & Vérine, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.06.009 · Cited by 29

Wine polyphenols and ethanol do not significantly scavenge superoxide nor affect endothelial nitric oxide production

Huisman, A., van de Wiel, A., Rabelink, T. J., & van Faassen, E. E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.01.006 · Cited by 28

The cytoprotective effect of α-tocopherol and daidzein against d-galactosamine–induced oxidative damage in the rat liver

Wong, M. C. Y., Portmann, B. C., Sherwood, R. A., Niemelä, O. J., Koivisto, H., Parkkila, S., Trick, K. D., L’Abbé, M. R., Wilson, J. W., Dash, P. R., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2007.01.005 · Cited by 27

Resveratrol modulates human mammary epithelial cell O-acetyltransferase, sulfotransferase, and kinase activation of the heterocyclic amine carcinogen N-hydroxy-PhIP

Dubuisson, J. G., Dyess, D. L., & Gaubatz, J. W. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00061-7 · Cited by 25

Antibacterial Activity of Stilbene Oligomers against Vancomycin-Resistant Enterococci (VRE) and Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Synergism with Antibiotics

Sakagami, Y., Sawabe, A., Komemushi, S., ALI, Z., Tanaka, T., Iliya, I., & Iinuma, M. (2007) · Biocontrol Science · doi:10.4265/bio.12.7 · Cited by 25

The effect of proanthocyanidin-rich hulls and proanthocyanidin extracts from bean (Vicia faba L.) hulls on nutrient digestibility and digestive enzyme activities in young chicks

Yuste, P., Longstaff, M., & McCorquodale, C. C. (1992) · British Journal Of Nutrition · doi:10.1079/bjn19920008 · Cited by 24

Environmental inhibition of 11β-hydroxysteroid dehydrogenase

Reidenberg, M. M. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00196-1 · Cited by 21

Inhibition of protein kinase CKII activity by resveratrol, a natural compound in red wine and grapes

Yoon, S., Kim, Y., Ghim, S., Song, B.-H., & Bae, Y. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01997-5 · Cited by 18

Inhibitory Effects of Soy Isoflavones on Cardiovascular Collagen Accumulation in Rats

Mizushige, T., Mizushige, K., Miyatake, A., Kishida, T., & Ebihara, K. (2007) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.53.48 · Cited by 15

Effects of Bulgarian red and white wines on primary hemostasis and experimental thrombosis in rats.

Wollny, T., Chabielska, E., Malinowska-Zaprzałka, M., Nazarko, J., Rozmysłowicz-Szermińska, W., & Buczko, W. (2003) · PubMed · Cited by 6

Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention

Huang, W.-Y., Cai, Y., & Zhang, Y. (2009) · Nutrition and Cancer · doi:10.1080/01635580903191585 · Cited by 1,012

Endothelial dysfunction — A major mediator of diabetic vascular disease

Sena, C. M., Pereira, A. M., & Seiça, R. M. F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.006 · Cited by 819

Health benefits of polyphenols: A concise review

Rana, A., Samtiya, M., Dhewa, T., Mishra, V., & Aluko, R. E. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14264 · Cited by 840

Potential Health Benefits of Olive Oil and Plant Polyphenols

Gorzynik-Debicka, M., Przychodzeń, P., Cappello, F., Kuban‐Jankowska, A., Marino, A., Knap, N., Woźniak, M., & Górska‐Ponikowska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030686 · Cited by 656

Dietary polyphenols as potential nutraceuticals in management of diabetes: a review

Bahadoran, Z., Mirmiran, P., & Azizi, F. (2013) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-12-43 · Cited by 601

Protective Effects of Dietary Polyphenols in Human Diseases and Mechanisms of Action

Shen, T., Han, X.-Z., Wang, X.-N., Fan, P.-H., Ren, D., & Lou, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-67625-8_13 · Cited by 10

New insights on the anticancer properties of dietary polyphenols

Fresco, P., Borges, F., Diniz, C., & Marques, M. P. M. (2006) · Medicinal Research Reviews · doi:10.1002/med.20060 · Cited by 549

Biochemical, Molecular, Pharmacokinetic, and Toxicological Aspects of Dietary Polyphenols

Rasmi, Y., da Silva, A. P. G., Rezaei, S., Rafique, S., & Ahmed, M. Z. (2022) · CRC Press eBooks · doi:10.1201/9781003251538-2 · Cited by 6

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2013

Maraldi, T., Vauzour, D., & Angeloni, C. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/576363 · Cited by 55

Dietary polyphenols: Antioxidants or not?

Croft, K. D. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.014 · Cited by 130