The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action
Open accessAbstract
There are presently more than 18 known aflatoxins most of which have been insufficiently studied for their incidence, health-risk, and mechanisms of toxicity to allow effective intervention and control means that would significantly and sustainably reduce their incidence and adverse effects on health and economy. Among these, aflatoxin B1 (AFB1) has been by far the most studied; yet, many aspects of the range and mechanisms of the diseases it causes remain to be elucidated. Its mutagenicity, tumorigenicity, and carcinogenicity—which are the best known—still suffer from limitations regarding the relative contribution of the oxidative stress and the reactive epoxide derivative (Aflatoxin-exo 8,9-epoxide) in the induction of the diseases, as well as its metabolic and synthesis pathways. Additionally, despite the well-established additive effects for carcinogenicity between AFB1 and other risk factors, e.g., hepatitis viruses B and C, and the hepatotoxic algal microcystins, the mechanisms of this synergy remain unclear. This study reviews the most recent advances in the field of the mechanisms of toxicity of aflatoxins and the adverse health effects that they cause in humans and animals.
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World map of the Köppen-Geiger climate classification updated
Kottek, M., Grieser, J., Beck, C., Rudolf, B., & Rubel, F. (2006) · Meteorologische Zeitschrift · doi:10.1127/0941-2948/2006/0130 · Cited by 11,456
Ayala, A., Muñoz, M. F., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,349
Oxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245
p21 in cancer: Intricate networks and multiple activities
Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712
Nature Reviews Molecular Cell Biology
(2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/41580.1471-0080 · Cited by 2,565
Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species
He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,127
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111
Nrf2 signaling pathway: pivotal roles in inflammation
Ahmed, S. M. U., Luo, L., Namani, A., Wang, X. J., & Tang, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.005 · Cited by 1,794
Williams, J. H., Phillips, T. D., Jolly, P. E., Stiles, J. K., Jolly, C. M., & Aggarwal, D. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1106 · Cited by 1,781
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
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Fungal toxins and host immune responses
Brown, R., Priest, E., Naglik, J. R., & Richardson, J. P. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.643639 · Cited by 94
Recent advances in metabolism and toxicity of tyrosine kinase inhibitors
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Metadata
- Authors
- Benkerroum, N.
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2020-01-08
- Volume
- 17
- Issue
- 2
- Pages
- 423
- ISSN
- 1660-4601 (ISSN-L)
- OpenAlex
- W2997972861
- Cited by
- 554
- References
- 147
- FWCI
- 40.62
- Type
- journal article
- Language
- en
- Open access
- gold
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