The Yin and Yang of Bacterial Resilience in the Human Gut Microbiota
Open accessAbstract
The human gut is home to trillions of microbes that form a symbiotic relationship with the human host. During health, the intestinal microbiota provides many benefits to the host and is generally resistant to colonization by new species; however, disruption of this complex community can lead to pathogen invasion, inflammation, and disease. Restoration and maintenance of a healthy gut microbiota composition requires effective therapies to reduce and prevent colonization of harmful bacteria (pathogens) while simultaneously promoting growth of beneficial bacteria (probiotics). Here we review the mechanisms by which the host modulates the gut community composition during health and disease, and we discuss prospects for antibiotic and probiotic therapy for restoration of a healthy intestinal community following disruption.
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Even in individuals with gut disorders, which favor colonization, the gut commensals often remain resilient to the establishment of exogenous probiotic strains.
“Even in individuals with gut disorders, which favor colonization, the gut commensals often remain resilient to the establishment of exogenous probiotic strains.8”
From Gut microbiota drives structural variation of exogenous probiotics to enhance colonization (2025) · cites this paper as [8]
The “Colonization Resistance for Beneficial Bacteria” section says two probiotic strains used to treat gastrointestinal disease are cleared from the majority of patients within weeks, supporting the claim that stable establishment is difficult. It does not say that gut disorders favor probiotic colonization; its discussion of colonization resistance specifically describes the stable adult gut microbiota. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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- Authors
- Gibson, M. K., Pesesky, M. W., & Dantas, G.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dantas, Gautam
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 426
- Issue
- 23
- Pages
- 3866-3876
- ISSN
- 0022-2836 (ISSN-L)
- PMC
- PMC4252752
- OpenAlex
- W2060255498
- Semantic Scholar
- bb519373ab0756e8f479e946a8b743ed9e8f476d
- Cited by
- 71
- References
- 96
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health Director's New Innovator Award
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of General Medical Sciences (DP2DK098089, R01GM099538)
- Kenneth Rainin Foundation Breakthrough Award (13H5)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, host-microbe interactions, dysbiosis, pathogen colonization, probiotics, antibiotic therapy, microbiota restoration, intestinal inflammation, microbiota composition
- MeSH terms
- Humans, Symbiosis, Gastrointestinal Tract, Host-Pathogen Interactions, Microbiota
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