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Cited by 149

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis

Coelho-Junior, Hélio, Calvani, Riccardo, Azzolino, Domenico, Picca, Anna, Tosato, Matteo, Landi, Francesco, Cesari, Matteo, Marzetti, Emanuele·2022·International Journal of Environmental Research and Public Health
DOI 10.3390/ijerph19148718
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Abstract

Background: The present systematic review and meta-analysis investigated the cross-sectional and longitudinal associations between protein intake and sarcopenia in older adults. Methods: Observational studies that investigated the association between protein intake and sarcopenia as the primary or secondary outcome in people aged 60 years and older were included. Studies published in languages other than English, Italian, Portuguese, and Spanish were excluded. Studies were retrieved from MEDLINE, SCOPUS, EMBASE, CINAHL, AgeLine, and Food Science Source databases through January 31, 2022. A pooled effect size was calculated based on standard mean differences. Results: Five cross-sectional studies, one longitudinal study, and one case-control study that investigated 3353 community-dwelling older adults with a mean age of approximately 73 years were included. The meta-analysis of four studies indicated that older adults with sarcopenia consumed significantly less protein than their peers with no sarcopenia. Conclusions: Results of the present study suggest that an inadequate protein intake might be associated with sarcopenia in older adults.

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Research works printed but not linked: 39

  1. Chen, 2014, Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia, J. Am. Med. Dir. Assoc., 15, 95, 10.1016/j.jamda.2013.11.025 · DOI · Paper page
  2. Dam, 2014, An Evidence-Based Comparison of Operational Criteria for the Presence of Sarcopenia, J. Gerontol. A Biol. Sci. Med. Sci., 69, 584, 10.1093/gerona/glu013 · DOI · Paper page
  3. Gao, Q., Hu, K., Yan, C., Zhao, B., Mei, F., Chen, F., Zhao, L., Shang, Y., Ma, Y., and Ma, B. (2021). Associated Factors of Sarcopenia in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. Nutrients, 13. · DOI · Paper page
  4. Chan, 2021, Sarcopenia and Mortality in Different Clinical Conditions: A Meta-Analysis, Osteoporos. Sarcopenia, 7, S19, 10.1016/j.afos.2021.02.001 · DOI
  5. Calvani, 2013, Current Nutritional Recommendations and Novel Dietary Strategies to Manage Sarcopenia, J. Frailty Aging, 2, 38
  6. Chen, 2022, Roles of Nutrition in Muscle Health of Community-dwelling Older Adults: Evidence-based Expert Consensus from Asian Working Group for Sarcopenia, J. Cachexia Sarcopenia Muscle, 13, 1653, 10.1002/jcsm.12981 · DOI
  7. Coelho-Junior, H.J., Marzetti, E., Picca, A., Cesari, M., Uchida, M.C., and Calvani, R. (2020). Protein Intake and Frailty: A Matter of Quantity, Quality, and Timing. Nutrients, 12. · DOI
  8. Deer, 2015, Protein Intake and Muscle Function in Older Adults, Curr. Opin. Clin. Nutr. Metab. Care, 18, 248, 10.1097/MCO.0000000000000162 · DOI · Paper page
  9. Katsanos, 2005, Aging Is Associated with Diminished Accretion of Muscle Proteins after the Ingestion of a Small Bolus of Essential Amino Acids, Am. J. Clin. Nutr., 82, 1065, 10.1093/ajcn/82.5.1065 · DOI · Paper page
  10. Moore, 2015, Protein Ingestion to Stimulate Myofibrillar Protein Synthesis Requires Greater Relative Protein Intakes in Healthy Older versus Younger Men, J. Gerontol. A Biol. Sci. Med. Sci., 70, 57, 10.1093/gerona/glu103 · DOI · Paper page
  11. Scott, 2001, Human Skeletal Muscle Fiber Type Classifications, Phys. Ther., 81, 1810, 10.1093/ptj/81.11.1810 · DOI · Paper page
  12. Martone, 2017, Exercise and Protein Intake: A Synergistic Approach against Sarcopenia, Biomed Res. Int., 2017, 2672435, 10.1155/2017/2672435 · DOI
  13. Bauer, 2019, Sarcopenia: A Time for Action. An SCWD Position Paper, J. Cachexia Sarcopenia Muscle, 10, 956, 10.1002/jcsm.12483 · DOI · Paper page
  14. Landi, 2014, Exercise as a Remedy for Sarcopenia, Curr. Opin. Clin. Nutr. Metab. Care, 17, 25
  15. Stroup, 2000, Meta-Analysis of Observational Studies in Epidemiology: A Proposal for Reporting. Meta-Analysis Of Observational Studies in Epidemiology (MOOSE) Group, JAMA, 283, 2008, 10.1001/jama.283.15.2008 · DOI · Paper page
  16. Shi, 2020, Optimally Estimating the Sample Standard Deviation from the Five-Number Summary, Res. Synth. Methods, 11, 641, 10.1002/jrsm.1429 · DOI · Paper page
  17. Rahman, 2021, Prevalence and Factors Contributing to Primary Sarcopenia in Relatively Healthy Older Indians Attending the Outpatient Department in a Tertiary Care Hospital: A Cross-Sectional Study, Aging Med., 4, 257, 10.1002/agm2.12186 · DOI
  18. Montiel-Rojas, D., Nilsson, A., Santoro, A., Bazzocchi, A., de Groot, L.C.P.G.M., Feskens, E.J.M., Berendsen, A.A.M., Madej, D., Kaluza, J., and Pietruszka, B. (2020). Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins. Nutrients, 12. · DOI
  19. Urtamo, 2020, Macronutrient Composition and Sarcopenia in the Oldest-Old Men, Clin. Nutr., 39, 3839, 10.1016/j.clnu.2020.04.024 · DOI
  20. Das, 2021, Associations between Nutrient Intakes and Dietary Patterns with Different Sarcopenia Definitions in Older Australian Men: The Concord Health and Ageing in Men Project, Public Health Nutr., 24, 4490, 10.1017/S1368980020003547 · DOI
  21. Beaudart, 2019, Association between Dietary Nutrient Intake and Sarcopenia in the SarcoPhAge Study, Aging Clin. Exp. Res., 31, 815, 10.1007/s40520-019-01186-7 · DOI
  22. Granic, 2020, Effects of Dietary Patterns and Low Protein Intake on Sarcopenia Risk in the Very Old: The Newcastle 85+ Study, Clin. Nutr., 39, 166, 10.1016/j.clnu.2019.01.009 · DOI
  23. Greenhaff, 2008, Disassociation between the Effects of Amino Acids and Insulin on Signaling, Ubiquitin Ligases, and Protein Turnover in Human Muscle, Am. J. Physiol. Endocrinol. Metab., 295, E595, 10.1152/ajpendo.90411.2008 · DOI · Paper page
  24. Wilkinson, 2013, Effects of Leucine and Its Metabolite β-Hydroxy-β-Methylbutyrate on Human Skeletal Muscle Protein Metabolism, J. Physiol., 591, 2911, 10.1113/jphysiol.2013.253203 · DOI · Paper page
  25. Wilkinson, 2018, The Age-Related Loss of Skeletal Muscle Mass and Function: Measurement and Physiology of Muscle Fibre Atrophy and Muscle Fibre Loss in Humans, Ageing Res. Rev., 47, 123, 10.1016/j.arr.2018.07.005 · DOI · Paper page
  26. Lexell, 1988, What Is the Cause of the Ageing Atrophy?. Total Number, Size and Proportion of Different Fiber Types Studied in Whole Vastus Lateralis Muscle from 15- to 83-Year-Old Men, J. Neurol. Sci., 84, 275, 10.1016/0022-510X(88)90132-3 · DOI · Paper page
  27. Burd, 2015, The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption, J. Nutr., 145, 1981, 10.3945/jn.114.204305 · DOI · Paper page
  28. Anthony, 2007, Feeding Meals Containing Soy or Whey Protein after Exercise Stimulates Protein Synthesis and Translation Initiation in the Skeletal Muscle of Male Rats, J. Nutr., 137, 357, 10.1093/jn/137.2.357 · DOI
  29. Mitchell, 2015, Soy Protein Ingestion Results in Less Prolonged P70S6 Kinase Phosphorylation Compared to Whey Protein after Resistance Exercise in Older Men, J. Int. Soc. Sports Nutr., 12, 6, 10.1186/s12970-015-0070-2 · DOI
  30. Dinu, 2017, Vegetarian, Vegan Diets and Multiple Health Outcomes: A Systematic Review with Meta-Analysis of Observational Studies, Crit. Rev. Food Sci. Nutr., 57, 3640, 10.1080/10408398.2016.1138447 · DOI · Paper page
  31. Bolster, 2004, Leucine Regulates Translation Initiation in Rat Skeletal Muscle Via Enhanced EIF4G Phosphorylation, J. Nutr., 134, 1704, 10.1093/jn/134.7.1704 · DOI
  32. Dardevet, 2000, Stimulation of in Vitro Rat Muscle Protein Synthesis by Leucine Decreases with Age, J. Nutr., 130, 2630, 10.1093/jn/130.11.2630 · DOI
  33. Calvani, 2019, High Relative Consumption of Vegetable Protein Is Associated with Faster Walking Speed in Well-Functioning Older Adults, Aging Clin. Exp. Res., 31, 837, 10.1007/s40520-019-01216-4 · DOI
  34. Schoufour, 2019, The Association between Dietary Protein Intake, Energy Intake and Physical Frailty: Results from the Rotterdam Study, Br. J. Nutr., 121, 393, 10.1017/S0007114518003367 · DOI
  35. Uchida, 2021, Evidence-Based Recommendations for Resistance and Power Training to Prevent Frailty in Community-Dwellers, Aging Clin. Exp. Res., 33, 2069, 10.1007/s40520-021-01802-5 · DOI
  36. Izquierdo, 2021, International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines, J. Nutr. Health Aging, 25, 824, 10.1007/s12603-021-1665-8 · DOI · Paper page
  37. Coelho-Júnior, H.J., Rodrigues, B., Uchida, M., and Marzetti, E. (2018). Low Protein Intake Is Associated with Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 10. · DOI
  38. Hugo, 2008, Association between Oral Health Status and Nutritional Status in South Brazilian Independent-Living Older People, Nutrition, 24, 546, 10.1016/j.nut.2008.01.054 · DOI
  39. Coelho-Junior, H.J., Calvani, R., Picca, A., Gonçalves, I.O., Landi, F., Bernabei, R., Cesari, M., Uchida, M.C., and Marzetti, E. (2020). Association between Dietary Habits and Physical Function in Brazilian and Italian Older Women. Nutrients, 12. · DOI

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Metadata

Authors
Coelho-Junior, H., Calvani, R., Azzolino, D., Picca, A., Tosato, M., Landi, F., Cesari, M., & Marzetti, E.
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2022-07-18
Volume
19
Issue
14
Pages
8718
ISSN
1660-4601
DOI
10.3390/ijerph19148718
Cited by
149
References
18
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Università Cattolica del Sacro Cuore
  • nonprofit research foundation Centro Studi Achille e Linda Lorenzon
  • Ministero della Salute—Ricerca Corrente 2022

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