Cited by 337Antimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsBacterial biofilms and quorum sensing

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The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

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Park, Seong-Cheol, Park, Yoonkyung, Hahm, Kyung-Soo·2011·International Journal of Molecular Sciences

DOI 10.3390/ijms12095971PMC PMC3189763

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Abstract

Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms, which are microbial communities that cause serious chronic infections and dental plaque, form environments that enhance antimicrobial resistance. As a result, there is a continuous search to overcome or control such problems, which has resulted in antimicrobial peptides being considered as an alternative to conventional drugs. Antimicrobial peptides are ancient host defense effector molecules in living organisms. These peptides have been identified in diverse organisms and synthetically developed by using peptidomimic techniques. This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. In addition, combinations of antimicrobial peptides and conventional drugs were considered due to their synergetic effects and low cost for therapeutic treatment.

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Figure 1 Three typical modes of action of antimicrobial peptides against cytoplasmic membranes. (A) barrel-stave model; (B) toroidal pore model; (C) carpet model.CC BY · PubMed Central

Figure 2 General overview of bacterial biofilm development. (1) reversible adsorption of bacteria; (2) irreversible attachment of bacteria; (3) production of extracelluar polymeric substance and biofilm growth; (4) maturation; (5) dispersion. After dispersion of the biofilm, bacteria move to other organs, tissues, or surfaces and a new biofilm is formed via stages (1)–(5).CC BY · PubMed Central

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Authors: Park, S.-C., Park, Y., & Hahm, K.-S.
Affiliations: Chosun University (KR)
Corresponding author: Park, Yoonkyung
Hahm, Kyung-Soo
ORCID: Park, Seong-Cheol
Park, Yoonkyung
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2011-09-16
Volume: 12
Issue: 9
Pages: 5971-5992
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms12095971
PMC: PMC3189763
OpenAlex: W2081930655
Cited by: 327
References: 184
Citations by year: 2026: 18 · 2025: 22 · 2024: 23 · 2023: 23 · 2022: 25 · 2021: 27 · 2020: 29 · 2019: 28 · 2018: 19 · 2017: 19 · 2016: 28 · 2015: 21 · 2014: 14 · 2013: 20 · 2012: 9
FWCI: 1.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Research Foundation
National Research Foundation of Korea (2011-0017532)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: antimicrobial peptides, multidrug-resistant bacteria, biofilm formation, antimicrobial resistance, peptidomimetics, chronic infection, medical device infections, oral health, dental plaque, combination therapy, mechanism of action
MeSH terms: Bacteria, Bacterial Infections, Humans, Microbial Sensitivity Tests, Models, Biological, Bacterial Physiological Phenomena, Biofilms, Antimicrobial Cationic Peptides, Drug Resistance, Multiple, Bacterial

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The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

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