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Cited by 337Antimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsBacterial biofilms and quorum sensing

The DOI matches its Crossref record; 181 of the 184 references it cites were found in a registry or an index.

The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

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Park, Seong-Cheol, Park, Yoonkyung, Hahm, Kyung-Soo·2011·International Journal of Molecular Sciences
DOI 10.3390/ijms12095971PMC PMC3189763
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Abstract

Over the last decade, decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. Furthermore, biofilms, which are microbial communities that cause serious chronic infections and dental plaque, form environments that enhance antimicrobial resistance. As a result, there is a continuous search to overcome or control such problems, which has resulted in antimicrobial peptides being considered as an alternative to conventional drugs. Antimicrobial peptides are ancient host defense effector molecules in living organisms. These peptides have been identified in diverse organisms and synthetically developed by using peptidomimic techniques. This review was conducted to demonstrate the mode of action by which antimicrobial peptides combat multidrug-resistant bacteria and prevent biofilm formation and to introduce clinical uses of these compounds for chronic disease, medical devices, and oral health. In addition, combinations of antimicrobial peptides and conventional drugs were considered due to their synergetic effects and low cost for therapeutic treatment.

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Figure 1 Three typical modes of action of antimicrobial peptides against cytoplasmic membranes. (A) barrel-stave model; (B) toroidal pore model; (C) carpet model.
Figure 1 Three typical modes of action of antimicrobial peptides against cytoplasmic membranes. (A) barrel-stave model; (B) toroidal pore model; (C) carpet model.CC BY · PubMed Central
Figure 2 General overview of bacterial biofilm development. (1) reversible adsorption of bacteria; (2) irreversible attachment of bacteria; (3) production of extracelluar polymeric substance and biofilm growth; (4) maturation; (5) dispersion. After dispersion of the biofilm, bacteria move to other organs, tissues, or surfaces and a new biofilm is formed via stages (1)–(5).
Figure 2 General overview of bacterial biofilm development. (1) reversible adsorption of bacteria; (2) irreversible attachment of bacteria; (3) production of extracelluar polymeric substance and biofilm growth; (4) maturation; (5) dispersion. After dispersion of the biofilm, bacteria move to other organs, tissues, or surfaces and a new biofilm is formed via stages (1)–(5).CC BY · PubMed Central

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Research works printed but not linked: 2

  1. Bierbaum, 2009, Lantibiotics: Mode of action, biosynthesis and bioengineering, Curr Pharm Biotechnol, 10, 2, 10.2174/138920109787048616 · DOI
  2. Nicolas, 2009, Multifunctional host defense peptides: Intracellular-targeting antimicrobial peptides, FEBS J, 276, 6483, 10.1111/j.1742-4658.2009.07359.x · DOI

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Metadata

Authors
Park, S.-C., Park, Y., & Hahm, K.-S.
Affiliations
Chosun University (KR)
Corresponding author
  • Park, Yoonkyung
  • Hahm, Kyung-Soo
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2011-09-16
Volume
12
Issue
9
Pages
5971-5992
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms12095971
PMC
PMC3189763
OpenAlex
W2081930655
Cited by
327
References
184
Citations by year
2026: 18 · 2025: 22 · 2024: 23 · 2023: 23 · 2022: 25 · 2021: 27 · 2020: 29 · 2019: 28 · 2018: 19 · 2017: 19 · 2016: 28 · 2015: 21 · 2014: 14 · 2013: 20 · 2012: 9
FWCI
1.65
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Research Foundation
  • National Research Foundation of Korea (2011-0017532)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
antimicrobial peptides, multidrug-resistant bacteria, biofilm formation, antimicrobial resistance, peptidomimetics, chronic infection, medical device infections, oral health, dental plaque, combination therapy, mechanism of action
MeSH terms
Bacteria, Bacterial Infections, Humans, Microbial Sensitivity Tests, Models, Biological, Bacterial Physiological Phenomena, Biofilms, Antimicrobial Cationic Peptides, Drug Resistance, Multiple, Bacterial

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