The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses
Open accessAbstract
Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems. Metals display a diverse array of physico-chemical properties such as essential versus non-essential and redox-active versus non-redox-active. In general, all metals can lead to toxicity and oxidative stress when taken up in excessive amounts, imposing a serious threat to the environment and human health. In order to cope with different kinds of metals, plants possess defense strategies in which glutathione (GSH; γ-glu-cys-gly) plays a central role as chelating agent, antioxidant and signaling component. Therefore, this review highlights the role of GSH in: (1) metal homeostasis; (2) antioxidative defense; and (3) signal transduction under metal stress. The diverse functions of GSH originate from the sulfhydryl group in cysteine, enabling GSH to chelate metals and participate in redox cycling.
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Cites
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Cited by
Phytoremediation: A Promising Approach for Revegetation of Heavy Metal-Polluted Land
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Chromium Bioaccumulation and Its Impacts on Plants: An Overview
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Metadata
- Authors
- Jozefczak, M., Remans, T., Vangronsveld, J., & Cuypers, A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2012-03-07
- Volume
- 13
- Issue
- 3
- Pages
- 3145-3175
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2016048871
- Cited by
- 810
- References
- 10
- FWCI
- 39.29
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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