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Cited by 51Pancreatic function and diabetesMangiferin and Mango ExtractsNatural Antidiabetic Agents Studies

Mangiferin facilitates islet regeneration and β-cell proliferation through upregulation of cell cycle and β-cell regeneration regulators

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Wang, Hai-Lian, Li, Chun-Yang, Zhang, Bin, Liu, Yuan-De, Lu, Bang-Min, Shi, Zheng, An, Na, Zhao, Liang-Kai +3 more·2014·International Journal of Molecular Sciences
DOI 10.3390/ijms15059016PMC PMC4057772
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Abstract

Mangiferin, a xanthonoid found in plants including mangoes and iris unguicularis, was suggested in previous studies to have anti-hyperglycemic function, though the underlying mechanisms are largely unknown. This study was designed to determine the therapeutic effect of mangiferin by the regeneration of β-cells in mice following 70% partial pancreatectomy (PPx), and to explore the mechanisms of mangiferin-induced β-cell proliferation. For this purpose, adult C57BL/6J mice after 7–14 days post-PPx, or a sham operation were subjected to mangiferin (30 and 90 mg/kg body weight) or control solvent injection. Mangiferin-treated mice exhibited an improved glycemia and glucose tolerance, increased serum insulin levels, enhanced β-cell hyperplasia, elevated β-cell proliferation and reduced β-cell apoptosis. Further dissection at the molecular level showed several key regulators of cell cycle, such as cyclin D1, D2 and cyclin-dependent kinase 4 (Cdk4) were significantly up-regulated in mangiferin-treated mice. In addition, critical genes related to β-cell regeneration, such as pancreatic and duodenal homeobox 1 (PDX-1), neurogenin 3 (Ngn3), glucose transporter 2 (GLUT-2), Forkhead box protein O1 (Foxo-1), and glucokinase (GCK), were found to be promoted by mangiferin at both the mRNA and protein expression level. Thus, mangiferin administration markedly facilitates β-cell proliferation and islet regeneration, likely by regulating essential genes in the cell cycle and the process of islet regeneration. These effects therefore suggest that mangiferin bears a therapeutic potential in preventing and/or treating the diabetes.

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  • Mangiferin facilitates beta-cell proliferation and islet regeneration through regulation of crucial genes in cell cycle and islet regeneration.

    “The results indicated that mangiferin facilitates β-cell proliferation and islet regeneration through the regulation of crucial genes in cell cycle and islet regeneration (Fig. 2C) (32).”

    From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [32]

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Cited by

Sorted by citations

Authors
Wang, H.-L., Li, C.-Y., Zhang, B., Liu, Y.-D., Lu, B.-M., Shi, Z., An, N., Zhao, L.-K., Zhang, J.-J., Bao, J.-K., & Wang, Y.
Affiliations
  • School of Life Sciences & Key Laboratory of Bio-Resources, Ministry of Education, Sichuan University, Chengdu 610064, China
  • Sichuan University (CN)
  • Department of Pharmacy, 91889 Military Hospital, Zhanjiang 524001, China
  • Institute of Neurology Science, Guangdong Medical University Affiliated Hospital, Zhanjiang 524001, China
  • Nationwide Children's Hospital (US)
Corresponding author
Wang, Yi
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2014-05-20
Volume
15
Issue
5
Pages
9016-9035
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms15059016
PMC
PMC4057772
OpenAlex
W2085950080
Cited by
51
References
8
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 1
FWCI
3.97
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (30970643, 31300674, 81373311, J1103518, No. 81373311, No. J1103518, 81173093)
  • Sichuan University
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
mangiferin, islet regeneration, beta-cell proliferation, beta-cell hyperplasia, beta-cell apoptosis, partial pancreatectomy, cell cycle regulators, cyclin D1, cyclin D2, CDK4, PDX1, Neurog3, GLUT2, FOXO1, glucokinase, glucose tolerance, insulin, diabetes treatment, xanthones
MeSH terms
Animals, Cells, Cultured, Glucose, Insulin, Islets of Langerhans, Male, Mice, Inbred C57BL, Regeneration, Up-Regulation, Apoptosis, Cyclin D1, Xanthones, Cell Proliferation, Insulin-Secreting Cells, Cyclin-Dependent Kinase 4, Mice, Cyclin D2

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