The DOI matches its Crossref record; 67 of the 69 references it cites were found in a registry or an index.
Oleocanthal, a Phenolic Derived from Virgin Olive Oil: A Review of the Beneficial Effects on Inflammatory Disease
Open accessAbstract
Virgin olive oil (VOO) is credited as being one of many healthful components of the Mediterranean diet. Mediterranean populations experience reduced incidence of chronic inflammatory disease states and VOO is readily consumed as part of an everyday dietary pattern. A phenolic compound contained in VOO, named oleocanthal, shares unique perceptual and anti-inflammatory characteristics with Ibuprofen. Over recent years oleocanthal has become a compound of interest in the search for naturally occurring compounds with pharmacological qualities. Subsequent to its discovery and identification, oleocanthal has been reported to exhibit various modes of action in reducing inflammatory related disease, including joint-degenerative disease, neuro-degenerative disease and specific cancers. Therefore, it is postulated that long term consumption of VOO containing oleocanthal may contribute to the health benefits associated with the Mediterranean dietary pattern. The following paper summarizes the current literature on oleocanthal, in terms of its sensory and pharmacological properties, and also discusses the beneficial, health promoting activities of oleocanthal, in the context of the molecular mechanisms within various models of disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“oleocanthal has been recognized as a potent anti-inflammatory agent [64], due to its analogy with the chemical structure of ibuprofen [16].”
From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
RetractedEstruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008
RetractedAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910
Mediterranean diet pyramid today. Science and cultural updates
Bach-Faig, A., Berry, E. M., Lairon, D., Reguant-Aleix, J., Trichopoulou, A., Dernini, S., Medina, F. X., Battino, M. A., Belahsen, R., Miranda, G., et al. (2011) · Public Health Nutrition · doi:10.1017/s1368980011002515 · Cited by 1,929
CORONARY HEART DISEASE IN SEVEN COUNTRIES
(1971) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1971.tb50629.x · Cited by 1,848
Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.
Masferrer, J. L., Leahy, K. M., Koki, A. T., Zweifel, B. S., Settle, S. L., Woerner, B. M., Edwards, D. A., Flickinger, A. G., Moore, R. J., & Seibert, K. (2000) · PubMed · Cited by 1,292
Physical Activity, Diet, and Risk of Alzheimer Disease
Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916
Ibuprofen-like activity in extra-virgin olive oil
Beauchamp, G. K., Keast, R. S. J., Morel, D., Lin, J., Pika, J., Han, Q., Lee, C.-H., Smith, A. B., & Breslin, P. A. S. (2005) · Nature · doi:10.1038/437045a · Cited by 885
Self-citationPrognostic significance of elevated cyclooxygenase-2 expression in breast cancer.
Ristimaki, A. P., Sivula, A., Lundin, J. E., Lundin, M., Salminen, T. M., Haglund, C. H., Joensuu, H., & Isola, J. J. (2002) · PubMed · Cited by 780
Flagged first, then by citations
2 of the 69 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Salen, 1999, Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction, Heart Fail., 11, 6
Cited by
Sorted by citations
Items 101–157 of 157
Wang, M., Xu, P., Liao, L., Gao, L., Amakye, W. K., Zhang, Y., Yao, M., & Ren, J. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100086 · Cited by 7
Dietary patterns and testosterone balance: a review of clinical data and perspectives
Liu, X., Li, X., Cai, D., Sun, J., & Bai, W. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.016 · Cited by 6
Abokhrais, I. M., Saunders, P. T. K., Denison, F. C., Doust, A. M., Williams, L. J., & Horne, A. W. (2018) · Pilot and Feasibility Studies · doi:10.1186/s40814-018-0274-8 · Cited by 6
Carpena, M., Garcia‐Oliveira, P., Pereira, A. G., Soria-López, A., Chamorro, F., Collazo, N., Jarboui, A., Simal‐Gándara, J., & Prieto, M. A. (2021) · Reference series in phytochemistry · doi:10.1007/978-3-030-45299-5_35-1 · Cited by 7
A Novel Process for Oleacein Production from Olive Leaves Using Freeze Drying Methodology
Koutra, C., Routsi, E., Stathopoulos, P., Kalpoutzakis, E., Humbert, M., Maubert, O., & Skaltsounis, A. (2025) · Foods · doi:10.3390/foods14020313 · Cited by 5
Olive oil compounds: biological and chemical actions for health- an updated review
Ghazali, R. F. (2026) · Food Chemistry Advances · doi:10.1016/j.focha.2026.101273 · Cited by 6
Impact of Extra-Virgin Olive Oil Storage Conditions on Phenolic Content and Wound-Healing Properties
Blasi, F., Ceccarini, M. R., Bistarelli, S., Galli, F., Cossignani, L., Bartolini, D., & Ianni, F. (2025) · Foods · doi:10.3390/foods14122104 · Cited by 5
Carpena, M., Garcia‐Oliveira, P., Pereira, A. G., Soria-López, A., Chamorro, F., Collazo, N., Jarboui, A., Simal‐Gándara, J., & Prieto, M. A. (2022) · Reference series in phytochemistry · doi:10.1007/978-3-030-78160-6_35 · Cited by 7
Amra, E.-S. A., Lashein, F. E.-D. M., Seleem, A. A., & Saleh, M. M. (2020) · The Journal of Basic and Applied Zoology · doi:10.1186/s41936-020-00182-y · Cited by 5
Chemesthetic Perception in Extra Virgin Olive Oil and Olive Ripening Stage: A Sensory Perspective
Panzani, S., Venturi, F., Taglieri, I., Ferroni, G., & Sanmartin, C. (2026) · Foods · doi:10.3390/foods15030519 · Cited by 4
Banik, S. P., Kumar, P., Basak, P., Goel, A., Ohia, S. E., Bagchi, M., Chakraborty, S., Kundu, A., & Bagchi, D. (2024) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2024.2401924 · Cited by 4
Torić, J., Barbarić, M., Uršić, S., Brala, C. J., Marković, A. K., Avdičević, M. Z., & Benčić, Đ. (2020) · Foods · doi:10.3390/foods9101347 · Cited by 4
Exploring the Immunotherapeutic Potential of Oleocanthal against Murine Cutaneous Leishmaniasis
Karampetsou, K. V., Koutsoni, O. S., Badounas, F., Angelis, A., Gogou, G., Skaltsounis, L.-A., Halabalaki, M., & Dotsika, E. (2022) · Planta Medica · doi:10.1055/a-1843-9788 · Cited by 4
Ammendola, S., Cocchiola, R., Lopreiato, M., Politi, L., Scandurra, R., Giusti, A. M., & d’Abusco, A. S. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1451409 · Cited by 4
Influence of Olive Oil Components on Ion Channels
Mijares-Andrade, H., Carreño-Diaz, I., Llave-León, O. L., Meneses‐Morales, I., Ruiz‐Baca, E., & López-Rodríguez, A. (2025) · Molecules · doi:10.3390/molecules30163336 · Cited by 3
Katsafadou, A. I., Prodromou, S. I., Aalizadeh, R., White, J. C., Τhomaidis, Ν. S., Vizirianakis, I. S., Anastas, P. T., Kyriakides, T. C., Pastides, H., Piscitelli, P., et al. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1658525 · Cited by 5
Effects of Mediterranean Diet on Chronic Degenerative Diseases and Human Healthy Lifestyle
Bonofiglio, D. (2025) · Nutrients · doi:10.3390/nu17071231 · Cited by 3
Cooking Oils, Salad Oils, and Dressings
Hill, S. E., Krishnamurthy, R. G., Hossain, A., & Shahidi, F. (2020) · Bailey's Industrial Oil and Fat Products · doi:10.1002/047167849x.bio058.pub2 · Cited by 3
Hammoud, R., Helou, R. E., Sabbagh, D., Fakih, N., Safieddine, Z., Malli, L., Jabbour, J., & Ibrahim, J.-N. (2025) · Pediatric Rheumatology · doi:10.1186/s12969-025-01167-3 · Cited by 2
Language Models and Food–Health Evidence: Challenges, Opportunities, and Implications
Jackson, D., Gousiopoulos, A., & Soldatos, T. G. (2026) · BioMedInformatics · doi:10.3390/biomedinformatics6020013 · Cited by 2
Georgieva, P., Peneva, P., & Gvozdeva, Y. (2026) · Applied Biosciences · doi:10.3390/applbiosci5030075 · Cited by 2
Olive oil oleocanthal and estrogen receptor expression
Ayoub, N. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819528-4.00053-5 · Cited by 2
Theoretical Evaluation of Oleocanthal Reactive Centers
Asgarshamsi, M. H., Dehkordi, M. M., Nazifi, S. M. R., & Zborowski, K. K. (2023) · Current Drug Metabolism · doi:10.2174/0113892002276499231201094142 · Cited by 2
Osman, W. A., Taher, H., Darweesh, H., Samie, M. A., Shaker, O. G., Labib, D. A. A., & Ateyya, H. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-024-00593-6 · Cited by 2
AlKhatib, A. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818649-7.00033-3 · Cited by 2
Vijeyakumar, C. P., Thangakumaran, S., & Sasikumar (2022) · International Journal of Research and Review · doi:10.52403/ijrr.20220503 · Cited by 2
Bazı Popüler Diyetlerin İmmünite Üzerine Etkileri
Adıgüzel, E., KILIÇ, Ş. N., YILMAZ, A., YURDAKUL, G., BİLEN, Ü. D., TENİL, A., & YILMAZ, İ. (2022) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.1194776 · Cited by 4
An Update on Herbal Products for the Management of Inflammatory Bowel Disease
Arya, H., Dass, R., Chopra, B., Kriplani, P., Deswal, G., Grewal, A. S., Dhingra, A. K., & Kumar, S. (2023) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523022666230727094250 · Cited by 2
Oleaceae plants: a source of metabolites with atheroprotective potential
Filipek, A., & Czepielewska, E. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1721433 · Cited by 1
A multifunctional nanofibrous scaffold–nanoemulsion system for improved diabetic wound healing
Ida, J. L. R., Kala, P. P., Paital, B., & Subramaniyan, V. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108464 · Cited by 1
Mangiferin and oleocanthal in the modulation of oxidative stress in monocytes and macrophages
Sharma, R., Anthikapalli, N. V. A., Kushwaha, R., Ovsii, A., Rác, M., Pospı́šil, P., Tamasi, G., Magnani, A., Rossi, C., & Prasad, A. (2026) · RSC Advances · doi:10.1039/d6ra01563h · Cited by 1
Effect of Mediterranean Dietary Pattern on Cognitive Status in Community-Dwelling Older Adults
Yaghi, N., El-Hayeck, R., Boulos, C., Abifadel, M., & Yaghi, C. (2023) · Nutrients · doi:10.3390/nu15183911 · Cited by 2
Ferro, M. D., Caño‐Carrillo, I., Gilbert‐López, B., Fernández-García, A., Cabrita, M. J., Herrera, J. M., & Duarte, M. F. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.102103 · Cited by 1
Parkinson, L., Kestin, M., & Keast, R. (2015) · Food Quality and Preference · doi:10.1016/j.foodqual.2015.08.006 · Cited by 1
Self-citationBioactive Components from Olive Oil as Putative Epigenetic Modulators
Shahidi, F., & Kiritsakis, A. K. (2017) · Wiley eBooks · doi:10.1002/9781119135340.ch23 · Cited by 1
Vassiliadis, S. (2015) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v5i10.190
CARACTERIZAÇÃO FÍSICA E SENSORIAL DE CAFÉ ARÁBICA EM RESPOSTA À ADUBAÇÃO E ÉPOCA DE COLHEITA
Rocha, R. S., Pereira, E. S., Zacarias, A. J., Pereira, I. M., Jaeggi, M. E. P. D. C., & Ferrari, J. L. (2017) · 30ª SEAGRO: ANAIS DA SEMANA ACADÊMICA DO CURSO DE AGRONOMIA DO CCAE/UFES
Nutritional Support After Surgery for Proctologic Diseases
Picciariello, A., & Rotelli, M. T. (2019) · Springer eBooks · doi:10.1007/978-3-030-16554-3_11
A Novel Structured Emulsion Containing Oleocanthal Enriched Extra Virgin Olive oil and Curcumin
Koteswari, P., Gowthami, P., Deepika, Y., & Abhishek Kumar, G. (2019) · American Journal of PharmTech Research · doi:10.46624/ajptr.2019.v9.i6.017
Antioxidants in olive oil phenolics: a focus on myoblasts
Kouka, P., Veskoukis, A. S., & Kouretas, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819528-4.00009-2
Jadhav, P. D. M. N. A. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.s08.151
Kırcı, D., & Ayaz, F. (2022) · Springer eBooks · doi:10.1007/978-3-031-07753-1_30
Health Effects: But is Olive Oil Good for You?
(2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782628569-00231
CLINICAL DIAGNOSTIC CRITERIA AND COMPLEX THERAPY TELOGENE ALOPECIA IN WOMEN
Ayzyatulov, R. F. (2023) · Dermatology and Venerology · doi:10.33743/2308-1066-2023-3-18-23
Iqbal, M. A., Feroze, M. A., Azam, M., Asif, M., Umer, M. A., Khan, M. A., Ali, H., Lyu, Q., Haider, S.-T.-A., Liaquat, M., et al. (2023) · Emirates Journal of Food and Agriculture · doi:10.9755/ejfa.2023.3124
Covataru, N.-A. (2023) · Dietetician ro · doi:10.26416/diet.4.4.2023.9091
Cooper, G., Bhattarai, P., Sather, B., Bailey, M. L., Chamberlin, M. L., Miles, M. P., & Bothner, B. B. (2025) · Metabolites · doi:10.3390/metabo15090599 · Cited by 1
Recent Studies on the Health Benefits of Olive Oil
Ok, S., Hatzakis, E., Mal, T. K., & Arslan, D. (2026) · Springer eBooks · doi:10.1007/978-3-032-07424-9_6
An Update on Herbal Remedies for Treatment of Alveolar Osteitis: A Narrative Review
Siriwattanadom, S., Kheawfu, K., Laosuwan, K., Wanachantararak, P., & Powcharoen, W. (2026) · European Journal of Dentistry · doi:10.1055/s-0045-1814462
Zhang, Z., Xu, M.-X., Wang, N., Shen, R., Sun, J., Zha, M., & Wang, M. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1695902 · Cited by 1
García, C. C. (2023) · theses.fr (ABES) · doi:10.70675/6ea195a8zbbc3z4188z9a08zbe738e998182
Victoria‐Montesinos, D., Barcina-Pérez, P., & García‐Muñoz, A. M. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70490
Vučina, R., Drmač, D., Rezić, V., Čulum, D., & Kondža, M. (2026) · Molecules · doi:10.3390/molecules31122134
Role of Bioactive Food Ingredients in Modulating Inflammation in Osteoarthritis
Ansari, M. M., & Son, Y. (2026) · Food bioactive ingredients · doi:10.1007/978-3-032-23814-6_8
Extra Virgin Olive Oil (EVOO) in Islamic and Modern Medicine
Rawwash, A. A., Hussein, E. A. F., Farag, D. E.-D. H., Bayomy, M. F. F., & Negm, S. H. I. (2026) · Baghdad Journal of Biochemistry and Applied Biological Sciences · doi:10.47419/bjbabs.v7i3.455
Wu, F., Guan, Q., Huang, Y., & Li, C. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c05684
Metadata
- Authors
- Parkinson, L., & Keast, R.
- Affiliations
- Deakin University (AU)
- Corresponding author
- Keast, Russell
- ORCID
- Keast, Russell
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2014-07-11
- Volume
- 15
- Issue
- 7
- Pages
- 12323-12334
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4139846
- OpenAlex
- W1974260088
- Cited by
- 156
- References
- 69
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 14 · 2021: 13 · 2020: 18 · 2019: 18 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Funders
- Deakin University
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- oleocanthal, virgin olive oil, phenolic compounds, anti-inflammatory activity, inflammatory diseases, ibuprofen, neurodegenerative diseases, cancer, Mediterranean diet, sensory properties, pharmacological mechanisms
- MeSH terms
- Olive Oil, Cyclopentane Monoterpenes, Aldehydes, Animals, Anti-Inflammatory Agents, Humans, Phenols, Plant Oils
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
