Cited by 157Edible Oils Quality and AnalysisPhytochemicals and Antioxidant ActivitiesFatty Acid Research and Health

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Oleocanthal, a Phenolic Derived from Virgin Olive Oil: A Review of the Beneficial Effects on Inflammatory Disease

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Parkinson, Lisa, Keast, Russell·2014·International Journal of Molecular Sciences

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Abstract

Virgin olive oil (VOO) is credited as being one of many healthful components of the Mediterranean diet. Mediterranean populations experience reduced incidence of chronic inflammatory disease states and VOO is readily consumed as part of an everyday dietary pattern. A phenolic compound contained in VOO, named oleocanthal, shares unique perceptual and anti-inflammatory characteristics with Ibuprofen. Over recent years oleocanthal has become a compound of interest in the search for naturally occurring compounds with pharmacological qualities. Subsequent to its discovery and identification, oleocanthal has been reported to exhibit various modes of action in reducing inflammatory related disease, including joint-degenerative disease, neuro-degenerative disease and specific cancers. Therefore, it is postulated that long term consumption of VOO containing oleocanthal may contribute to the health benefits associated with the Mediterranean dietary pattern. The following paper summarizes the current literature on oleocanthal, in terms of its sensory and pharmacological properties, and also discusses the beneficial, health promoting activities of oleocanthal, in the context of the molecular mechanisms within various models of disease.

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Figure 1 It is possible that receptor levels of TRPA-1 in muscle reflect levels in the oropharyngeal region. Therefore low or high levels of TRPA-1 in the oropharyngeal region may reflect the inflammatory responses in muscle through activation of P38 MAPK.CC BY · PubMed Central

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Authors: Parkinson, L., & Keast, R.
Affiliations: Deakin University (AU)
Corresponding author: Keast, Russell
ORCID: Keast, Russell
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2014-07-11
Volume: 15
Issue: 7
Pages: 12323-12334
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms150712323
PMC: PMC4139846
OpenAlex: W1974260088
Cited by: 156
References: 69
Citations by year: 2026: 15 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 14 · 2021: 13 · 2020: 18 · 2019: 18 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 2
FWCI: 0.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Funders: Deakin University
Topics: Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: oleocanthal, virgin olive oil, phenolic compounds, anti-inflammatory activity, inflammatory diseases, ibuprofen, neurodegenerative diseases, cancer, Mediterranean diet, sensory properties, pharmacological mechanisms
MeSH terms: Olive Oil, Cyclopentane Monoterpenes, Aldehydes, Animals, Anti-Inflammatory Agents, Humans, Phenols, Plant Oils

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Oleocanthal, a Phenolic Derived from Virgin Olive Oil: A Review of the Beneficial Effects on Inflammatory Disease

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