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Oleocanthal, a Phenolic Derived from Virgin Olive Oil: A Review of the Beneficial Effects on Inflammatory Disease
Open accessAbstract
Virgin olive oil (VOO) is credited as being one of many healthful components of the Mediterranean diet. Mediterranean populations experience reduced incidence of chronic inflammatory disease states and VOO is readily consumed as part of an everyday dietary pattern. A phenolic compound contained in VOO, named oleocanthal, shares unique perceptual and anti-inflammatory characteristics with Ibuprofen. Over recent years oleocanthal has become a compound of interest in the search for naturally occurring compounds with pharmacological qualities. Subsequent to its discovery and identification, oleocanthal has been reported to exhibit various modes of action in reducing inflammatory related disease, including joint-degenerative disease, neuro-degenerative disease and specific cancers. Therefore, it is postulated that long term consumption of VOO containing oleocanthal may contribute to the health benefits associated with the Mediterranean dietary pattern. The following paper summarizes the current literature on oleocanthal, in terms of its sensory and pharmacological properties, and also discusses the beneficial, health promoting activities of oleocanthal, in the context of the molecular mechanisms within various models of disease.
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“oleocanthal has been recognized as a potent anti-inflammatory agent [64], due to its analogy with the chemical structure of ibuprofen [16].”
From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [64]
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“In extra-virgin olive oil, indeed, a large body of phenolic compounds has been identified and, among these, oleocanthal has been recognized as a potent anti-inflammatory agent [64], due to its analogy with the chemical structure of ibuprofen [16].”
BackgroundThe Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?
Mazzocchi, A., Leone, L., Agostoni, C., & Pali-Schöll, I. (2019) · Nutrients · doi:10.3390/nu11122941 · Cited by 252
Metadata
- Authors
- Parkinson, L., & Keast, R.
- Affiliations
- Deakin University (AU)
- Corresponding author
- Keast, Russell
- ORCID
- Keast, Russell
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2014-07-11
- Volume
- 15
- Issue
- 7
- Pages
- 12323-12334
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4139846
- OpenAlex
- W1974260088
- Cited by
- 156
- References
- 69
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 14 · 2021: 13 · 2020: 18 · 2019: 18 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Funders
- Deakin University
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- oleocanthal, virgin olive oil, phenolic compounds, anti-inflammatory activity, inflammatory diseases, ibuprofen, neurodegenerative diseases, cancer, Mediterranean diet, sensory properties, pharmacological mechanisms
- MeSH terms
- Olive Oil, Cyclopentane Monoterpenes, Aldehydes, Animals, Anti-Inflammatory Agents, Humans, Phenols, Plant Oils
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