Ibuprofen-like activity in extra-virgin olive oil
Open accessAbstract
Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
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Fifty grams of newly pressed extra-virgin olive oil contains up to 9 mg of olechantal, a phytochemical with ibuprofen-like COX-inhibitory activity.
“Furthermore, it has been shown that 50 g of newly pressed extra-virgin olive oil contains up to 9 mg of olechantal, a phytochemical with ibuprofen-like COX-inhibitory activity (61).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [61]
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- Authors
- Beauchamp, G. K., Keast, R. S. J., Morel, D., Lin, J., Pika, J., Han, Q., Lee, C.-H., Smith, A. B., & Breslin, P. A. S.
- Affiliations
- Monell Chemical Senses Center (US)
- University of the Sciences (US)
- Firmenich (United States) (US)
- University of Pennsylvania (US)
- Konkuk University (KR)
- Corresponding author
- Breslin, Paul A. S.
- ORCID
- Venue
- Nature
- Published
- 2005-08-31
- Volume
- 437
- Issue
- 7055
- Pages
- 45-46
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2009789674
- Cited by
- 885
- References
- 12
- Citations by year
- 2026: 36 · 2025: 31 · 2024: 37 · 2023: 39 · 2022: 48 · 2021: 66 · 2020: 50 · 2019: 59 · 2018: 51 · 2017: 42 · 2016: 26 · 2015: 43 · 2014: 37 · 2013: 44 · 2012: 37
- FWCI
- 23.14
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- oleocanthal, extra virgin olive oil, anti-inflammatory agents, cyclooxygenase inhibition, prostaglandin synthesis, phenolic compounds, pungency, nonsteroidal anti-inflammatory drugs, Mediterranean diet, inflammation
- MeSH terms
- Olive Oil, Cyclopentane Monoterpenes, Aldehydes, Anti-Inflammatory Agents, Non-Steroidal, Dietary Fats, Unsaturated, Ibuprofen, Phenols, Plant Oils, Molecular Structure, Cyclooxygenase Inhibitors, Olea
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