Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation
Open accessAbstract
Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models generated so far. To define the role of mitochondrial fission in muscle development and repair, we have generated a transgenic mouse line that overexpresses the fission-inducing protein Drp1 specifically in skeletal muscle. These mice displayed a drastic impairment in postnatal muscle growth, with reorganisation of the mitochondrial network and reduction of mtDNA quantity, without the deficiency of mitochondrial bioenergetics. Importantly we found that Drp1 overexpression activates the stress-induced PKR/eIF2 α /Fgf21 pathway thus leading to an attenuated protein synthesis and downregulation of the growth hormone pathway. These results reveal for the first time how mitochondrial network dynamics influence muscle growth and shed light on aspects of muscle physiology relevant in human muscle pathologies.
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Overexpression of fission proteins or certain metabolic conditions inducing mitochondrial fission adversely impacts skeletal muscle development and repair.
“For instance, overexpression of the fission proteins, or certain metabolic conditions inducing mitochondrial fission, adversely impacts skeletal muscle development and repair [49], leading to muscle atrophy [50].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [49]
Even a mild imbalance between fusion and fission impairs skeletal muscle mass.
“Of particular importance, even a mild imbalance between fusion and fission has been demonstrated to impair skeletal muscle mass [49].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [49]
Constitutive overexpression of DRP1 in skeletal muscle causes muscle loss and decreased exercise performance.
“Accordingly, the constitutive overexpression of DRP1 in skeletal muscle caused muscle loss and decreased exercise performance.”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [210]
There is strong evidence in skeletal muscle supporting a causal link between dysregulation of mitochondrial fission and alterations in muscle maintenance.
“There is strong evidence in skeletal muscle that supports a causal link between the dysregulation of mitochondrial fission and alterations in muscle maintenance [152, 196, 197, 210, 211].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [210]
In a DRP1 overexpression mouse model, stress-induced mitochondria-dependent signals activate both the UPRmt and the eIF2α-ATF4-FGF21 axis, causing a reduction in protein synthesis and a blockade of growth hormone actions that prevent muscle growth.
“In this mouse model, stress-induced mitochondria-dependent signals activate both the UPRmt and the eIF2α–ATF4– FGF21 axis, causing a reduction in protein synthesis and a blockade of growth hormones actions that prevent muscle growth [210].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [210]
Overexpression of the fission proteins Drp1 and Fis1 in muscles causes muscle atrophy.
“On the other hand, the overexpression of the fission proteins Drp1 and Fis1 in muscles causes muscle atrophy [5,7].”
From Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles (2019) · cites this paper as [7]
Failure in mitochondrial-shaping processes has detrimental consequences for the maintenance of muscle mass and function.
“Accordingly, the failure in mitochondrial-shaping processes has detrimental consequences for the maintenance of muscle mass and function [4,5,6,7,8,13,29].”
From Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles (2019) · cites this paper as [7]
Overexpression of DRP1 is sufficient to activate an atrophy program via the AMPK-FoxO3 axis.
“we and others have shown that overexpression of DRP1 is sufficient to activate an atrophy program via the AMPK-FoxO3 axis10,11.”
From DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass (2019) · cites this paper as [11]
Loss-of-function approach shows decrease of mitofusin2 and downregulation of calnexin and upregulation of Bip/Grp78.
“Another peculiarity of the loss-of-function approach is the decrease of the ER-mitochondria tethering protein mitofusin2 and the down- and upregulation of the ER chaperones calnexin and Bip/Grp78, respectively11.”
From DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass (2019) · cites this paper as [11]
Drp1 is a key player in regulating skeletal muscle development and maintenance.
“indicating that Drp1 is a key player in regulating skeletal muscle development and maintenance.”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [39]
Mitochondrial fission is essential for skeletal muscle health.
“Taken altogether, the findings discussed above clearly indicate that mitochondrial fission is essential for skeletal muscle health.”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [39]
Muscle-specific Drp1 overexpression impairs skeletal muscle growth in mice.
“Muscle-specific Drp1 overexpression was shown to impair skeletal muscle growth in mice [39,40].”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [39]
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- Authors
- Touvier, T., De Palma, C., Rigamonti, E., Scagliola, A., Incerti, E., Mazelin, L., Thomas, J.-L., D'Antonio, M., Politi, L., Schaeffer, L., Clementi, E., & Brunelli, S.
- Affiliations
- IRCCS Eugenio Medea (IT)
- IRCCS Ospedale San Raffaele (IT)
- École Normale Supérieure de Lyon (FR)
- University of Milan (IT)
- Corresponding author
- Clementi, E
- Brunelli, S
- Venue
- Cell Death & Disease
- Published
- 2015-02-26
- Volume
- 6
- Issue
- 2
- Pages
- e1663-e1663
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC4669802
- OpenAlex
- W2002049655
- Cited by
- 140
- References
- 52
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 14 · 2023: 14 · 2022: 11 · 2021: 22 · 2020: 17 · 2019: 12 · 2018: 11 · 2017: 6 · 2016: 4 · 2015: 2
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by)
- Funders
- European Commission (241440)
- Ministero della Salute (RC2015, GR–2011–02350544, PRIN 2010-2011)
- Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN 2010-2011 “, (PRIN 2010))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- Drp1, mitochondrial fission, mitochondrial dynamics, skeletal muscle growth, translational attenuation, PKR, eIF2α, FGF21, myogenesis, mitochondrial DNA, transgenic mouse model, muscle regeneration
- MeSH terms
- Animals, DNA, Mitochondrial, Mice, Transgenic, Oxygen Consumption, Blotting, Western, Muscle, Skeletal, Dynamins, Immunoprecipitation, Mice, Membrane Potential, Mitochondrial
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