The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes
Open accessAbstract
After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be disposed in tissues where they do not exert clinically-relevant effects. Therapeutically-relevant effects are usually terminated by drug metabolism and/or elimination. The role that has been traditionally ascribed to the spleen in these fundamental pharmacokinetic processes was definitely marginal. However, due to its high blood flow and to the characteristics of its microcirculation, this organ would be expected to be significantly exposed to large, new generation drugs that can hardly penetrate in other tissues with tight endothelial barriers. In the present review, we examine the involvement of the spleen in the disposition of monoclonal antibodies, nanoparticles and exosomes and the possible implications for their therapeutic efficacy and toxicity. The data that we will review lead to the conclusion that a new role is emerging for the spleen in the pharmacokinetics of new generation drugs, hence suggesting that this small, neglected organ will certainly deserve stronger attention by pharmacologists in the future.
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Cites
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Cited by
Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery
Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · doi:10.20944/preprints201810.0507.v1 · Cited by 605
Chen, S., Tang, Y., Liu, Y., Zhang, P., Lv, L., Zhang, X., Jia, L., & Zhou, Y. (2019) · Cell Proliferation · doi:10.1111/cpr.12669 · Cited by 344
Shieh, P., Nguyen, H. V.-T., & Johnson, J. A. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0352-4 · Cited by 233
Metadata
- Authors
- Cataldi, M., Vigliotti, C., Mosca, T., Cammarota, M., & Capone, D.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-06-10
- Volume
- 18
- Issue
- 6
- Pages
- 1249
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2622879993
- Cited by
- 267
- References
- 137
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cataldi, M., Vigliotti, C., Mosca, T., Cammarota, M., & Capone, D. (2017). Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18061249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
