Markers of T Cell Senescence in Humans

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

The future of immune checkpoint therapy

Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452

Cellular senescence: from physiology to pathology

Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

Weber, J. S., D’Angelo, S. P., Minor, D. R., Hodi, F. S., Gutzmer, R., Neyns, B., Höeller, C., Khushalani, N. I., Miller, W. H., Lao, C. D., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)70076-8 · Cited by 2,725

Pathogen Recognition by the Innate Immune System

Kumar, H., Kawai, T., & Akira, S. (2011) · International Reviews of Immunology · doi:10.3109/08830185.2010.529976 · Cited by 2,368

Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors

Magri, S., Masetto, E., Solito, S., Francescato, S., Belluzzi, E., Pozzuoli, A., Berizzi, A., Ruggieri, P., & Mandruzzato, S. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00199-5 · Cited by 15

Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing

Franzin, R., Stasi, A., Castellano, G., & Gesualdo, L. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1507-2_6 · Cited by 14

Characterization of KIR + NKG2A + Eomes− NK‐like CD8+ T cells and their decline with age in healthy individuals

Kasakovski, D., Zeng, X., Lai, J., Yu, Z. H., Yao, D., Chen, S., Zha, X., Li, Y., & Xu, L. (2020) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21945 · Cited by 14

Pro-tumorigenic role of type 2 diabetes-induced cellular senescence in colorectal cancer

Melia, F., Udomjarumanee, P., Zinovkin, D. A., Arghiani, N., & Pranjol, M. Z. I. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.975644 · Cited by 14

Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells

Téllez‐Bañuelos, M. C., Ochoa, S. G., Ortiz‐Lazareno, P. C., Rosas‐González, V. C., Gómez-Villela, J., & Haramati, J. (2019) · Journal of Immunotoxicology · doi:10.1080/1547691x.2019.1668513 · Cited by 14

Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges

Francavilla, F., Intranuovo, F., Spada, G. L., Lacivita, E., Catto, M., Graps, E. A., & Altomare, C. (2024) · ChemMedChem · doi:10.1002/cmdc.202400672 · Cited by 13

Ageing of T-dependent B cell responses

Martinez, F., Novarino, J., Mejía, J. E., Fazilleau, N., & Aloulou, M. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.03.012 · Cited by 15

Loss of CD96 Expression as a Marker of HIV-Specific CD8+ T-Cell Differentiation and Dysfunction

Bunet, R., Nayrac, M., Ramani, H., Sylla, M., Durand, M., Chartrand‐Lefebvre, C., Routy, J., LANDAY, A. L., Gauchat, J., Chomont, N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673061 · Cited by 15

Functional and concurrent training do not impair immune function and improve functional fitness in postmenopausal women: A randomized controlled trial

Aragão-Santos, J. C., Vasconcelos, A. B. S., de Resende–Neto, A. G., Rodrigues, L. S., Silva, N. D. L., da Silva, D. N., Schimieguel, D. M., Corrêa, C. B., & Silva‐Grigoletto, M. E. D. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111504 · Cited by 14

The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation

Li, Y., Zhang, N., Ma, C., Xu, W., Jin, G., Zheng, Y., Zhang, L., Liu, B., Gao, C., & Liu, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04289-0 · Cited by 13

Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients

Moysidou, E., Λιούλιος, Γ., Xochelli, A., Nikolaidou, V., Christodoulou, M., Mitsoglou, Z., Stai, S., Fylaktou, A., Papagianni, A. A., & Stangou, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314688 · Cited by 13

Insights to the HIV-associated visceral leishmaniasis clinical outcome: lessons learned about immune mediated disorders

Silva-Freitas, M. L., Corrêa-Castro, G., Da‐Cruz, A. M., & Santos-Oliveira, J. R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1516176 · Cited by 12

Human platelet lysate enhances in vivo activity of CAR-Vδ2 T cells by reducing cellular senescence and apoptosis

Mo, F., Tsai, C., Zheng, R., Cheng, C., Heslop, H. E., Brenner, M. K., Mamonkin, M., & Watanabe, N. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.03.006 · Cited by 12

T cell aging and exhaustion: Mechanisms and clinical implications

Zhang, W., Kong, D., Zhang, X., Hu, L., Nian, Y., & Shen, Z. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110486 · Cited by 13

DJ‐1 depletion prevents immunoaging in T‐cell compartments

Zeng, N., Capelle, C., Baron, A., Kobayashi, T., Cire, S., Tslaf, V., Leonard, C., Coowar, D., Koseki, H., Westendorf, A. M., et al. (2022) · EMBO Reports · doi:10.15252/embr.202153302 · Cited by 13

Activation and increased production of interleukin‐17 and tumour necrosis factor‐α of mucosal‐associated invariant T cells in patients with periodontitis

Kim, O., Park, K., Jin, H., Cho, Y., Kim, Y. S., Kwon, S., Koh, J., Ju, J. K., Kee, S., & Park, Y. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13648 · Cited by 13

The aging common marmoset's immune system: From junior to senior

Mietsch, M., Paqué, K., Drummer, C., Stahl‐Hennig, C., & Roshani, B. (2020) · American Journal of Primatology · doi:10.1002/ajp.23128 · Cited by 11

Immune senescence in non-small cell lung cancer management: therapeutic relevance, biomarkers, and mitigating approaches

Alexa‐Stratulat, T., Tanasa, M. P., Cianga, V. A., & Antoniu, S. A. (2022) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2022.2139242 · Cited by 11

Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies

Gadoth, A., Ourfalian, K., Basnet, S., Kunzweiler, C. P., Bohn, R. L., Fülöp, T., & Diaz-Decaro, J. D. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2560 · Cited by 10

Immunosenescence accelerates atherosclerosis development in AAV-PCSK9 mouse model

de Mol, J., Smit, V., Kleijn, M. N. A. B., van Santbrink, P. J., Bot, I., & Foks, A. C. (2025) · GeroScience · doi:10.1007/s11357-025-01768-6 · Cited by 10

Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation

Autaa, G., Korenkov, D. A., van Beek, J., Pellegrin, I., Parfait, B., van Baarle, D., Launay, O., Tartour, É., & Appay, V. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00542-8 · Cited by 10

Effects of functional and combined training on subsets of memory T cells and functional fitness of postmenopausal women: A randomized controlled trial

Vasconcelos, A. B. S., Aragão-Santos, J. C., de Resende–Neto, A. G., Rodrigues, L. S., Corrêa, C. B., Schimieguel, D. M., Camargo, E. A., Ramos, S. D. P., & Silva‐Grigoletto, M. E. D. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111898 · Cited by 10

T Lymphocytes and Their Potential Role in Dementia with Lewy Bodies

Amin, J., Gee, C., Stowell, K., Coulthard, D., & Boche, D. (2023) · Cells · doi:10.3390/cells12182283 · Cited by 10

Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty

Mohyuddin, H., Laffón, B., Teixeira, J. P., Costa, S., Gomes, A., Pásaro, E., Constantine, N. T., Dagdag, A., Ortmeyer, H. K., Tizenberg, B., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad228 · Cited by 10

Partial recovery of senescence in circulating follicular helper T cells after Dasatinib treatment

Talepoor, A. G., Khosropanah, S., & Doroudchi, M. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107465 · Cited by 10

Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease

Ratnatunga, C. N., Tungatt, K., Proietti, C., Halstrom, S., Holt, M. R., Lutzky, V. P., Price, P., Doolan, D. L., Bell, S. C., Field, M. A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047781 · Cited by 9

T Lymphocytes in Patients With Nijmegen Breakage Syndrome Demonstrate Features of Exhaustion and Senescence in Flow Cytometric Evaluation of Maturation Pathway

Piątosa, B., Wolska‐Kuśnierz, B., Tkaczyk, K., Heropolitańska–Pliszka, E., Grycuk, U., Wakulińska, A., & Gregorek, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01319 · Cited by 9

Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification

Lázničková, P., Bendíčková, K., Kepák, T., & Frič, J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.708788 · Cited by 10

Characterization of T cell immunophenotypes in intestinal transplantation: A pilot study

Guerra, M. R., Rossetti, M. M., Zhang, Z., Zhou, X., Whang, E. C., Venick, R. S., Marcus, E. A., McDiarmid, S. V., Farmer, D. G., Reed, E. F., et al. (2018) · Transplant Immunology · doi:10.1016/j.trim.2018.09.003 · Cited by 9

Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases

Chen, Y. J., Liao, Y., Tram, V. T. N., Lin, C. H., Liao, K., & Liu, C.-L. (2020) · Life · doi:10.3390/life10100246 · Cited by 9

T-cell senescence: Unlocking the tumor immune “Dark Box” - A multidimensional analysis from mechanism to tumor immunotherapeutic intervention

Cheng, J., Zheng, J., Ma, C., Li, Y., & Hao, H. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.010 · Cited by 8

Recent advances in biomarkers for senescence: Bridging basic research to clinic

Fukumoto, T., Shimosawa, T., Yakabe, M., Yoshida, S. Y., & Yoshida, Y. (2025) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.15054 · Cited by 8

Proceso de agotamiento de las células T durante la infección crónica causada por tripanosomátidos intracelulares

López, M. C., Pérez-Antón, E., & Thomas, M. C. (2019) · Ars Pharmaceutica (Internet) · doi:10.30827/ars.v60i2.9432 · Cited by 8

Myocardial inflammation comes of age

Appel, M., Frantz, S., & Ramos, G. C. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.09.006 · Cited by 8

Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)

Bolton, C. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00473-w · Cited by 9

Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study

Granic, A., Martin-Ruiz, C. M., Rimmer, L., Dodds, R. M., Robinson, L. A., Spyridopoulos, I., Kirkwood, T. B. L., von Zglinicki, T., & Sayer, A. A. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111739 · Cited by 7

Towards a better preclinical cancer model – human immune aging in humanized mice

Tan, J. H. L., Hwang, Y. Y., Chin, H. X., Liu, M., Tan, S. Y., & Chen, Q. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00374-4 · Cited by 8

IL-7 producing immunotherapy improves ex vivo T cell functions of immunosenescent patients, especially post hip fracture

Marton, C., Minaud, A., Coupet, C., Chauvin, M., Dhiab, J., Vallet, H., Boddaert, J., Kehrer, N., Bastien, B., Inchauspé, G., et al. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2232247 · Cited by 7

Activation and Impaired Tumor Necrosis Factor-α Production of Circulating Mucosal-Associated Invariant T Cells in Patients with Trauma

Jo, Y. G., Jin, H., Cho, Y., Kim, J.-C., Kee, S., & Park, Y.-W. (2019) · Journal of Innate Immunity · doi:10.1159/000499343 · Cited by 8

Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccination

Carré, C., Wong, G. C. L., Narang, V., Tan, C. T., Chong, J., Chin, H. X., Xu, W., Lu, Y., Chua, M., Poidinger, M., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102970 · Cited by 7

Effector memory T cell subset CD45RA−CCR7−CD27−CD28 − EM3 increases in direct proportion to the disease severity of COVID ‐19

Kızmaz, M. A., Şimşek, A., Bozkurt, T., Çağan, E., Dombaz, F., Tezcan, G., Aşan, A., Demir, H. I., Bal, S. H., Yöyen-Ermiş, D., et al. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13217 · Cited by 6

Immune signatures predicting responses to immunomodulatory antibody therapy

Pawelec, G. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.003 · Cited by 6

Accelerated T-cell senescence and persistent inflammation in older adults with rheumatoid arthritis

Cezar, C. D., Scholl, J. N., Rabelo, C. F., Madruga, M. P., Silva, P. L., Grün, L. K., Engroff, P., Bressanim, A. C. M., Scherer, R. T., Schwanke, C. H. A., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115518 · Cited by 5

The proportion of CD57+ cells among effector CD8+ T cells is lower in HIV controllers compared with antiretroviral therapy-treated patients

Henriquez, S., Lécuroux, C., Bitu, M., Avettand-Fènoël, V., Churaqui, F., Catalan, P., Chéret, A., Boufassa, F., Sáez‐Cirión, A., Monceaux, V., et al. (2019) · AIDS · doi:10.1097/qad.0000000000002342 · Cited by 5

Potential Role of Diabetes Mellitus-Associated T Cell Senescence in Epithelial Ovarian Cancer Omental Metastasis

Broadway, R., Patel, N. M., Hillier, L. E., El-briri, A., Korneva, Y. S., Zinovkin, D. A., & Pranjol, M. Z. I. (2021) · Life · doi:10.3390/life11080788 · Cited by 5

SATB1, senescence and senescence‐related diseases

Qi, W., Bai, J., Wang, R., Zeng, X., & Zhang, L. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31327 · Cited by 6

Immune Response Gaps Linked to SARS-CoV-2 Infection: Cellular Exhaustion, Senescence, or Both?

Barbosa, L. V., Prá, D. M. M., Nagashima, S., Pereira, M. R. C., Stocco, R. B., da Silva, F. D. L. F., Cruz, M. R., Dallagassa, D., Stupak, T. J., Götz, G. W. X. D. R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213734 · Cited by 5

Alterations in the CD56− and CD56+ T Cell Subsets during COVID-19

Vavilova, J. D., Ustiuzhanina, M. O., Boyko, A. A., Streltsova, M. A., Kust, S. A., Kanevskiy, L. M., Iskhakov, R. N., Sapozhnikov, A. M., Gubernatorova, E. O., Drutskaya, M. S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109047 · Cited by 5

Are There Reliable Biomarkers for Immunosenescence and Inflammaging?

Fülöp, T., Cohen, A. A., Wong, G. C. L., Witkowski, J. M., & Larbi, A. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24970-0_15 · Cited by 5

Intestinal Microbiota and Aging in People with HIV—What We Know and What We Don’t

Islam, S. M. S., Singh, S. T., Keshavarzian, A., & Abdel‐Mohsen, M. (2024) · Current HIV/AIDS Reports · doi:10.1007/s11904-024-00717-w · Cited by 4

Immunosenescence in Kidney Transplant Recipients

Memmos, E., Λιούλιος, Γ., Antoniadis, N., Fylaktou, A., & Stangou, M. J. (2025) · Transplantation · doi:10.1097/tp.0000000000005484 · Cited by 4

Intestinal T cells in aging: implications for gut barrier integrity and inflammaging

Stevens, C. M., Schaaf, C. R., DeConne, T. M., & Kavanagh, K. (2026) · GeroScience · doi:10.1007/s11357-026-02292-x · Cited by 5

Immunosenescence and Cancer Immunotherapy at Old Age: Basics

Fülöp, T., Witkowski, J. M., Hirokawa, K., Larbi, A., & Pawelec, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-44870-1_77-1 · Cited by 4

Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients

Shin, J. J., Catanzaro, J., Yonkof, J. R., Delmonte, O. M., Sacco, K. A., Shin, M. S., Reddy, S., Whittington, P. J., Soffer, G. K., Mustillo, P., et al. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-00968-x · Cited by 4

Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling

Syrimi, E., Khan, N., Murray, P., Willcox, C. R., Haigh, T. A., Willcox, B. E., Masand, N., Bowen, C., Dimakou, D. B., Zuo, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110837 · Cited by 4

Both in vitro T cell proliferation and telomere length are decreased, but CD25 expression and IL-2 production are not affected in aged men

Albarrán-Tamayo, F., Murillo-Ortiz, B. O., Amaro, R. G., & López-Briones, S. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.87593 · Cited by 4

Possibilities of using T-cell biophysical biomarkers of ageing

González‐Bermúdez, B., Abarca‐Ortega, A., González-Sánchez, M., la Fuente, M. D., & Plaza, G. R. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.29 · Cited by 4

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancerPreprint

Muroyama, Y., Manne, S., Wellhausen, N., Oldridge, D. A., Greenplate, A. R., Chilukuri, L., Mathew, D., Xu, C., Herati, R. S., Berger, S. L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.16.488552 · Cited by 4

Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer

Cui, F., Yan, C., Wu, J., Yang, Y., Yang, J., Luo, J., & Li, N. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1556496 · Cited by 3

Immunocyte senescence: A new perspective on the remodeling of the ovarian cancer microenvironment and therapeutic intervention

Li, X., Li, X., Ni, S., Zhang, X., & Liu, B. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101492 · Cited by 3

IMMUNOPROPHYLAXIS REDUCTION EFFECTIVENESS IN ELDERLY DETERMINED BY IMMUNE RESPONSE SENESCENCE

., A. S. D. P., de Araujo, I. M., ., A. M. B. C., Sobrinho, C. M. T. R., ., J. R. R. F., Gonçalves, M. R., da Cruz, C. M., & de Lima, C. M. F. (2021) · Journal of Bio Innovation · doi:10.46344/jbino.2021.v10i02.25 · Cited by 3

Differing natural killer cell, T cell and antibody profiles in antiretroviral-naive HIV-1 viraemic controllers with and without protective HLA alleles

Moyano, A., Ndlovu, B., Mbele, M., Naidoo, K. K., Khan, N., Mann, J. K., & Ndung’u, T. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286507 · Cited by 3

Immunological features of ESRD patients undergoing hemodialysis of various ages

Chen, X., Xiang, F., Cao, X., Lv, W., Shen, B., Zou, J., & Ding, X. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03683-1 · Cited by 3

Integrin activation enables rapid detection of functional Vδ1+ and Vδ2+ γδ T cells

Herold, N., Schöllhorn, A., Feile, A., Gaißler, A., Mohrholz, A., Pawelec, G., Loeffler, M. W., Dimitrov, S., Gouttefangeas, C., & Wistuba‐Hamprecht, K. (2022) · European Journal of Immunology · doi:10.1002/eji.202149682 · Cited by 4

Cholesterol metabolism in T‐cell aging: Accomplices or victims

Hu, C., Wu, H., Zhu, Q., Cao, N., & Wang, H. (2023) · The FASEB Journal · doi:10.1096/fj.202300515r · Cited by 3

T-Cell Phenotypes and Systemic Cytokine Profiles of People Living with HIV Admitted to Hospital with COVID-19

van der Mescht, M. A., Steel, H. C., de Beer, Z., Masenge, A., Abdullah, F., Ueckermann, V., Anderson, R., & Rossouw, T. M. (2024) · Microorganisms · doi:10.3390/microorganisms12112149 · Cited by 2

Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial

Rodríguez-Moreno, J. F., de Velasco, G., Álvarez-Fernández, C., Collado, R., Fernández, R., Vázquez, S., Virizuela, J. A., Gajate, P., Pous, A. F., Laínez, N., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-2890 · Cited by 2

Profiling of circulating T-cells with prognostic and predictive value in early and advanced stage PDAC

Xagara, A., Vasilieva, K., Kokkalis, Α., Lazarou, A., Christodoulopoulos, G., Papadopoulos, V. N., Chantzara, E., Koinis, F., Saloustros, E. S., Kallergi, G., et al. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04190-1 · Cited by 2

The cellular senescence–metabolism axis: emerging insights into T cell dynamics in the context of biological aging

Garza‐Martinez, L., & Fitzgerald-Bocarsly, P. A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02525-0 · Cited by 2

Protocol for generating high-quality, 45-color spectral flow cytometry data for unsupervised clustering to investigate aging in human PBMCs

Krause, C. J., Higuchi, A., Tashiro, S., Nakagawa, K., Otsuka, F., Yotoriyama, T., Futamura, K., & Furuki, M. (2026) · STAR Protocols · doi:10.1016/j.xpro.2026.104380 · Cited by 3

CD57-Expressing Lymphocytes: From Chronic Viral Response to Age-Related Inflammation

Vallejo-Bermúdez, I. M., Miranda-Echagüe, M. R., Fernández-Álvarez, S., Reina-Alfonso, I., Blanca-Pariente, L., Batista-Duharte, A., & Pera, A. (2026) · Cells · doi:10.3390/cells15050403 · Cited by 3

Targeting Age-Associated Immune Senescence via Nanoparticle-Based Metabolic Reprogramming

Nair, P. G., Unnikrishnan, B. S., Vijayan, V. V., Howlett, S. E., Cullis, P. R., & Gujar, S. A. (2026) · ACS Nano · doi:10.1021/acsnano.5c18638 · Cited by 2

Older Adults’ Wellbeing

Machina, M., Mpofu, E., Rivera-Torres, S., Knight, R., & Abah, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-59687-3_13 · Cited by 2

Effect of L-Carnitine and/or Calf Thymus Gland Extract Supplementation on Immunity, Antioxidant, Duodenal Histomorphometric, Growth, and Economic Performance of Japanese Quail (Coturnix coturnix japonica)

Abu-Alya, I., Alharbi, Y., Abdel-Rahman, H. A., & Zahran, I. (2021) · Veterinary Sciences · doi:10.3390/vetsci8110251 · Cited by 2

The generation of senescent-like CD4+ EMRA T cells in T2D and their contribution to poor COVID-19 vaccine responses

Garrod-Ketchley, C., d’Algue, L. M., Littlewood, K., Hood, G., Worthington, A., Pattrick, M., Sutcliffe, C., Valla, Z., Joti, N., Zalak, U., et al. (2023) · Discovery Immunology · doi:10.1093/discim/kyad026 · Cited by 2

Gearing up for the Future: Mitigating Dysregulated Inflammation in Aging and Facets of Obesity

Xu, W., & Larbi, A. (2020) · Immunometabolism · doi:10.20900/immunometab20210002 · Cited by 2

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults

Herold, N., Wingerter, S., Hähnel, K., Larsen, L. A., Christensen, K., Pawelec, G., & Wistuba‐Hamprecht, K. (2021) · Cells · doi:10.3390/cells10020373 · Cited by 2

COLUMNS

(2018) · Asia-Pacific Biotech News · doi:10.1142/s0219030318000484 · Cited by 2

DJ-1 depletion prevents immunoaging in T-cell compartments

Zeng, N., Capelle, C., Baron, A. G., Kobayashi, T., Ciré, S., Tslaf, V., Leonard, C. A., Coowar, D., Koseki, H., Westendorf, A. M., et al. (2022) · immuneACCESS · doi:10.21417/nz2022embor · Cited by 2

Correlation between the percentage of memory T cells and IFN-γ level in patients with systemic lupus erythematous

Handono, K., Ulfah, F., Octaviani, H., & Kalim, H. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1246/1/012015 · Cited by 1

ANTIOXIDANTLY-MODULATIVE, CHEMOPREVENTIVE AND ANTI-SARS-COVID 19 ACTION OF MEDICINAL PLANTS

Karamalakova, Y. D., Georgieva, E. D., Ivanov, V., Parlapanska, K., & Nikolova, G. D. (2022) · Trakia Journal of Sciences · doi:10.15547/tjs.2022.04.001 · Cited by 1

Detection and Characterization of Senescent Cells with Flow Cytometry

Bakouros, P., Archavli, A., Kostopoulos, I. V., Terpos, E., Kastritis, E., Dimopoulos, M. A., Tsitsilonis, O., & Rousakis, P. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4426-3_4 · Cited by 1

Tráfico leucocitario: mecanismos e impacto clínico

León-Oliva, D. D., Boaru, D. L., Castro-Martinez, P. D., Dı́az, R., López-González, L., Álvarez-Mon, M., & Ortega, M. A. (2025) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2025.03.014 · Cited by 1

Correlation Between the Proportion of Senescence-Associated β-Galactosidase-Stained CD8+ T Cells and Age: A Cross-Sectional Study in Japan

Tsubokawa, M., Shimizu, Y., Yazaki, M., Shimodan, S., Noguchi, M., Yamazaki, A., Watanabe, T., Ocho, M., Sakurada, T., Hirose, Y., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188799 · Cited by 1

Parental clinical manifestation association with newborn immune senescence and telomere biology in Pakistan

Farrukh, S., & Baig, S. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07498-4 · Cited by 1

Extracellular Vesicles Favor Early Peripheral Immunosenescence Through Modulation of the Senescence‐Associated Secretory Phenotype in HIV Infection

Castro, R. C., Gravina, H. D., Sugiyama, F. H. C., Lamarre, Y., Fontanari, C., Powell, B. H., Gololobova, O. A., Liao, Z., Almeida, F. B. D. R., Kashima, S. H., et al. (2025) · Aging Cell · doi:10.1111/acel.70320 · Cited by 1

Apheresis CD8+CCR7+CD45RA− T-Cells as a Novel Biomarker Associated with CAR T-Cell Kinetics and Clinical Outcome

de la Torre, I. G., García‐Hoz, C., Martín‐Moro, F., Fernández-Velasco, J. I., Velázquez‐Kennedy, K., Rodríguez‐Martín, E., Luna, A., Roldán, E., Jiménez, G. M., Lopéz-Jimenéz, J., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020866 · Cited by 1

Targeting tumor microenvironment-associated cells to reverse therapy resistance

Piranlioglu, R., Bradford, J. W., & Arbab, A. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822527-1.00006-x · Cited by 1

The Life-Long Consequences of Prenatal and Childhood Stress on the Innate and Adaptive Immune System

Giacobbe, J., Pariante, C. M., & Borsini, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-71229-7_2 · Cited by 1

Vaccination with Tozimameran Induces T-Cell Activation, but Not Senescent or Exhaustive Alterations, in Kidney Transplant Recipients

Stai, S., Λιούλιος, Γ., Xochelli, A., Παπαδοπούλου, Α., Yannaki, E., Kasimatis, E., Christodoulou, M., Moysidou, E., Samali, M., Testa, T., et al. (2024) · Vaccines · doi:10.3390/vaccines12080877 · Cited by 1

Precision medicine to manage chronic immune-related conditions

Gibson, D. S., Egan, P., Guo, G., Kelly, C., McClean, P. L., McGilligan, V., McAllister, R., Matchett, K. B., Martin, C. A., Murray, E. K., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824390-9.00009-8 · Cited by 1

Radiotherapy and Systemic Anti-Cancer Treatment in Older Adults with Cancer and Frailty

O’Donovan, A., Baldini, C., & Battisti, N. M. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-89162-6_14 · Cited by 2

MULHERES COM HIV DIANTE DA IMPOSSIBILIDADE DE AMAMENTAR: O PAPEL DO ENFERMEIRO DIANTE DOS DESAFIOS

Matsumoto, H., Vidal, S. V., Tomaz, D. C. M. F., & Pacheco, P. M. D. C. F. (2024) · doi:10.22533/at.ed.24924080312 · Cited by 1

The Immunosenescence of �? & ?� T cells in human blood and skin

Xu, W. (2019) · doi:10.32657/10220/47613

Impact of Psychological and Physical Stressors on the Exercise-Induced Immune Response in Collegiate Swimmers

Kuremsky, C. A. (2018) · Louisiana State University · doi:10.31390/gradschool_theses.4845

Avaliação de imunossenescência precoce em pacientes com imunodeficiência comum variável (ICV)

Coutinho, É. M. M. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2020.tde-03072020-150741

Immunity, Aging, and the Works of V.M. Dilman

Polevshchikov, A. V., & Nazarov, P. G. (2021) · Advances in Gerontology · doi:10.1134/s2079057021030103

AGING WITH T CELLS

Pieren, D. K. J. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/572

Estudio celular de la inmunosenescencia en adultos mayores vacunados y en pacientes con cáncer de mama

Rodríguez, R., & Johanna, I. (2021)

Improving year-round protection against influenza infection in the tropics

Young, B. E. (2021) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/155395

T Cell-Mediated Immunity in the Immunosenescence Process

Lang, P. O. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_10 · Cited by 1

Immunosenescence Study of T Cells: A Systematic Review

Rodríguez, I. J., Lalinde-Ruiz, N., León, M. L., Martínez-Enriquez, L. C., Velásquez, M. D. P. M., Aguirre, J. P. O., Bohórquez, O. M. R., Vargas, E. A. V., Hernández-Álvarez, E. D., & Parra-López, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604591 · Cited by 229

Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories

Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401174 · Cited by 259

Immunosenescence: Analysis and Genetic Modulation of Replicative Senescence in T Cells

Effros, R. B., & Valenzuela, H. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.305 · Cited by 2

Reliable Hallmarks and Biomarkers of Senescent Lymphocytes

Сергеевна, М. Ю., Tereshchenko, V., Bogdanova, D. A., & Александрович, Р. С. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115653 · Cited by 28