Cited by 264Telomeres, Telomerase, and SenescenceT-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

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Markers of T Cell Senescence in Humans

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Xu, Weili, Larbi, Anis·2017·International Journal of Molecular Sciences

DOI 10.3390/ijms18081742PMC PMC5578132

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Abstract

Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers.

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The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878
T cell exhaustion
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
Weber, J. S., D’Angelo, S. P., Minor, D. R., Hodi, F. S., Gutzmer, R., Neyns, B., Höeller, C., Khushalani, N. I., Miller, W. H., Lao, C. D., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)70076-8 · Cited by 2,725
Pathogen Recognition by the Innate Immune System
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The World Bank (1993). Investing in Health: World Development Indicators, Oxford University Press.
Janeway, C.A., Travers, P., Walport, M., and Shlomchik, M.J. (2017, June 10). B-cell activation by armed helper T cells, Immunobiology: The Immune System in Health and Disease, Available online: https://www.ncbi.nlm.nih.gov/books/NBK27142/.
Janeway, C.A., Travers, P., Walport, M., and Shlomchik, M.J. (2017, June 11). Macrophage activation by armed CD4 TH1 cells, Immunobiology: The Immune System in Health and Disease, Available online: https://www.ncbi.nlm.nih.gov/books/NBK27153/.
Janeway, C.A., Travers, P., Walport, M., and Shlomchik, M.J. (2017, June 12). T cell-mediated cytotoxicity, Immunobiology: The Immune System in Health and Disease, Available online: https://www.ncbi.nlm.nih.gov/books/NBK27101/.

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Additional file 6 of The effect of metformin on senescence of T lymphocytes
Yang, J., Liu, H.-C., Zhang, J.-Q., Zou, J.-Y., Zhang, X., Chen, W.-M., Gu, Y., & Hong, H. (2024) · Figshare · doi:10.6084/m9.figshare.26652471
Additional file 3 of Towards a better preclinical cancer model – human immune aging in humanized mice
Tan, J. H. L., Hwang, Y. Y., Chin, H. X., Liu, M., Tan, S. Y., & Chen, Q. (2023) · Figshare · doi:10.6084/m9.figshare.24202746
Additional file 4 of Towards a better preclinical cancer model – human immune aging in humanized mice
Tan, J. H. L., Hwang, Y. Y., Chin, H. X., Liu, M., Tan, S. Y., & Chen, Q. (2023) · Figshare · doi:10.6084/m9.figshare.24202749
Additional file 1 of Towards a better preclinical cancer model – human immune aging in humanized mice
Tan, J. H. L., Hwang, Y. Y., Chin, H. X., Liu, M., Tan, S. Y., & Chen, Q. (2023) · Figshare · doi:10.6084/m9.figshare.24202740
Additional file 2 of The effect of metformin on senescence of T lymphocytes
Yang, J., Liu, H.-C., Zhang, J.-Q., Zou, J.-Y., Zhang, X., Chen, W.-M., Gu, Y., & Hong, H. (2024) · Figshare · doi:10.6084/m9.figshare.24798069
Additional file 3 of The effect of metformin on senescence of T lymphocytes
Yang, J., Liu, H.-C., Zhang, J.-Q., Zou, J.-Y., Zhang, X., Chen, W.-M., Gu, Y., & Hong, H. (2024) · Figshare · doi:10.6084/m9.figshare.26652462
Additional file 2 of Towards a better preclinical cancer model – human immune aging in humanized mice
Tan, J. H. L., Hwang, Y. Y., Chin, H. X., Liu, M., Tan, S. Y., & Chen, Q. (2023) · Figshare · doi:10.6084/m9.figshare.24202743
Additional file 1 of The effect of metformin on senescence of T lymphocytes
Yang, J., Liu, H.-C., Zhang, J.-Q., Zou, J.-Y., Zhang, X., Chen, W.-M., Gu, Y., & Hong, H. (2023) · Figshare · doi:10.6084/m9.figshare.24797813
Additional file 5 of The effect of metformin on senescence of T lymphocytes
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Additional file 4 of The effect of metformin on senescence of T lymphocytes
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Sun, C., Chen, X., Li, J., Hu, L., Shi, R., Li, C., & Wang, C. (2026) · Discover Oncology · doi:10.1007/s12672-026-04550-y
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Nguyen, H. Q. (2019) · theses.fr (ABES) · doi:10.70675/6c94f1c0z17d2z42cazb118z8c7e07496c2b
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Richer, W. (2021) · theses.fr (ABES) · doi:10.70675/97f429e9z2993z4b78z88dezf46fae0d3a30
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Chu, H.-T., Zhao, H., Wang, S.-S., Meng, X., Wang, D., Zhu, X.-B., Wang, Y., & Yang, X.-W. (2026) · Immunity & Ageing · doi:10.1186/s12979-026-00587-3
Cellular Senescence-Associated Gene Expression in Circulating CD4+, CD8+, CD19+ Lymphocytes of HNSCC Patients: Associations with Clinical Parameters
Ostrowska, K., Niewiński, P., Piotrowski, I., Kubicka, A., Ostapowicz, J., Kozikowska, J., Jazikowska, A., Czochór, K., Marchlewska, J., Procyk, D., et al. (2026) · Cells · doi:10.3390/cells15161477
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Zhu, M., Zhang, J., Fang, H., Cai, K., Wu, Q., Gao, C., Wang, Y., & Chen, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1917096
Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models
Pellegrini, V., Grotta, R. L., Metallo, A., Prattichizzo, F., Frigé, C., Matacchione, G., Giuliani, A., Sabbatinelli, J., Olivieri, F., Rispoli, F., et al. (2026) · MedComm · doi:10.1002/mco2.71082
From T-cell renewal to immune longevity: a multilevel capacity framework for immune aging
Li, H., & Zhi, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1996492

Authors: Xu, W., & Larbi, A.
Affiliations: Agency for Science, Technology and Research (SG)
Corresponding author: Larbi, Anis
ORCID: Xu, Weili
Larbi, Anis
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2017-08-10
Volume: 18
Issue: 8
Pages: 1742
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms18081742
PMC: PMC5578132
OpenAlex: W2744554795
Cited by: 261
References: 107
Citations by year: 2026: 16 · 2025: 26 · 2024: 47 · 2023: 24 · 2022: 32 · 2021: 48 · 2020: 28 · 2019: 23 · 2018: 16 · 2017: 1
FWCI: 2.28
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
Funders: Graduiertenakademie, Technische Universität Dresden
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: T cell senescence, immunosenescence, T-cell markers, aging, older adults, influenza vaccination, age-related immune decline
MeSH terms: Immunosenescence, Aging, Cell Differentiation, Humans, T-Lymphocytes, Immunophenotyping, Cellular Senescence

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Markers of T Cell Senescence in Humans

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