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Estrogen Effects on Wound Healing
Open accessAbstract
Wound healing is a physiological process, involving three successive and overlapping phases—hemostasis/inflammation, proliferation, and remodeling—to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.
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“In fact, estrogen is found to be involved in all phases of wound healing27.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
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“estrogen is very important to wound healing27,28”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
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“Indeed, peripheral tissues produce estrogens71, and estrogens play a vital role in wound healing27,28.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
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Topical estrogen cream for chondrodermatitis nodularis helicis
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Liu, H., Wang, J., Li, F., Yang, W., Zheng, Y., Yin, Y., Wei, Q., Hong, G., & Liu, Z. (2026) · BMC Women s Health · doi:10.1186/s12905-026-04567-z
Mahatme, R. J., Moore, S. A., Gangavaram, A., Muthusamy, N., Reddy, E., Gerak, S. K., & Grawe, B. M. (2026) · Cureus · doi:10.7759/cureus.110003
Peña, B. L., Diwakar, K. M., Tran, H. K., Cao, S., Lintz, C. E., Hayes, L. N., Alperin, M., & Christman, K. L. (2026) · Advanced Science · doi:10.1002/advs.202600052
Layton, B., Prasad, D., Patel, D., & Rehman, S. (2026) · Arthroplasty Today · doi:10.1016/j.artd.2026.102068
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Metadata
- Authors
- Horng, H.-C., Chang, W.-H., Yeh, C.-C., Huang, B.-S., Chang, C.-P., Chen, Y.-J., Tsui, K.-H., & Wang, P.-H.
- Affiliations
- Taipei Veterans General Hospital (TW)
- Tajen University (TW)
- Corresponding author
- Wang, Peng-Hui
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-11-03
- Volume
- 18
- Issue
- 11
- Pages
- 2325
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5713294
- OpenAlex
- W2765643716
- Cited by
- 208
- References
- 107
- Citations by year
- 2026: 23 · 2025: 33 · 2024: 27 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 27 · 2019: 17 · 2018: 7
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Taipei Veterans General Hospital (V104C-095, V106C-129; V106D23-001-MY2-1, V105C-096, V106C-129, V106A-012, V106D23-001-MY2-1)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- estrogen, wound healing, estrogen deficiency, postmenopausal women, skin homeostasis, inflammation, re-epithelialization, hemostasis, tissue remodeling, estrogen therapy
- MeSH terms
- Animals, Estrogens, Hemostasis, Humans, Inflammation, Receptors, Estrogen, Wound Healing, Signal Transduction, Cell Proliferation, Drug Discovery
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