The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Estrogen Effects on Wound Healing
Open accessAbstract
Wound healing is a physiological process, involving three successive and overlapping phases—hemostasis/inflammation, proliferation, and remodeling—to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.
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In the citing paper
“In fact, estrogen is found to be involved in all phases of wound healing27.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
In the citing paper
“estrogen is very important to wound healing27,28”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
In the citing paper
“Indeed, peripheral tissues produce estrogens71, and estrogens play a vital role in wound healing27,28.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
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Cites
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Distinct fibroblast lineages determine dermal architecture in skin development and repair
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Diabetes and Wound Angiogenesis
Okonkwo, U. A., & DiPietro, L. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071419 · Cited by 1,071
Estrogen receptors regulate innate immune cells and signaling pathways
Kovats, S. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.01.018 · Cited by 1,021
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis
Ogawa, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030606 · Cited by 985
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
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Driskell, R. R., & Watt, F. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.001 · Cited by 425
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Metadata
- Authors
- Horng, H.-C., Chang, W.-H., Yeh, C.-C., Huang, B.-S., Chang, C.-P., Chen, Y.-J., Tsui, K.-H., & Wang, P.-H.
- Affiliations
- Taipei Veterans General Hospital (TW)
- Tajen University (TW)
- Corresponding author
- Wang, Peng-Hui
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-11-03
- Volume
- 18
- Issue
- 11
- Pages
- 2325
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5713294
- OpenAlex
- W2765643716
- Cited by
- 208
- References
- 107
- Citations by year
- 2026: 23 · 2025: 33 · 2024: 27 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 27 · 2019: 17 · 2018: 7
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Taipei Veterans General Hospital (V104C-095, V106C-129; V106D23-001-MY2-1, V105C-096, V106C-129, V106A-012, V106D23-001-MY2-1)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- estrogen, wound healing, estrogen deficiency, postmenopausal women, skin homeostasis, inflammation, re-epithelialization, hemostasis, tissue remodeling, estrogen therapy
- MeSH terms
- Animals, Estrogens, Hemostasis, Humans, Inflammation, Receptors, Estrogen, Wound Healing, Signal Transduction, Cell Proliferation, Drug Discovery
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