The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion
Open accessAbstract
Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important effector molecule of anti-tumor immunity, capable of suppressing tumor growth through various mechanisms. On the contrary to such a bright side of IFN-γ, it has also been involved in promoting an outgrowth of tumor cells with immunoevasive phenotype suggesting an existence of a dark “tumor-promoting” side effect of IFN-γ. In this review, we will summarize this multi-functional role of IFN-γ in tumor context, how it promotes changes in tumor phenotype towards increased fitness for growth in immunocompetent host. Furthermore, we summarize how IFN-γ is involved in homeostatic or cancer-triggered mechanisms to establish an immunosuppressive tumor microenvironment.
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The Role of RhoH in TCR Signalling and Its Involvement in Diseases
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Metadata
- Authors
- Mojic, M., Takeda, K., & Hayakawa, Y.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-12-28
- Volume
- 19
- Issue
- 1
- Pages
- 89
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2781052937
- Cited by
- 334
- References
- 101
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- gold
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