The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Mechanisms of ATP Release by Inflammatory Cells
Open accessAbstract
Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation. Necrosis leads to non-specific release of nucleotides, whereas specific release mechanisms include vesicular exocytosis and channel-mediated release via connexin or pannexin hemichannels. These release mechanisms allow stimulated inflammatory cells such as macrophages, neutrophils, and endothelial cells to fine-tune autocrine/paracrine responses during acute and chronic inflammation. Key effector functions of inflammatory cells are therefore regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies.
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Cited by
Increased Extracellular ATP in Plasma of Rheumatoid Arthritis Patients Activates CD8+T Cells
Tripathy, A., Padhan, P., Swain, N., Raghav, S. K., & Gupta, B. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.12.010 · Cited by 14
Metadata
- Authors
- Dosch, M., Gerber, J., Jebbawi, F., & Beldi, G.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-04-18
- Volume
- 19
- Issue
- 4
- Pages
- 1222
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2801022696
- Cited by
- 283
- References
- 113
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- gold
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