The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Role of Human Macrophage Polarization in Inflammation during Infectious Diseases
Open accessAbstract
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1-like and M2-like macrophages is rather represented by a continuum, where boundaries are still unclear. Indeed, human infectious diseases, are characterized by either a back and forth or often a mixed profile between the pro-inflammatory microenvironment (dominated by interleukin (IL)-1β, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-α cytokines) and tissue injury driven by classically activated macrophages (M1-like) and wound healing driven by alternatively activated macrophages (M2-like) in an anti-inflammatory environment (dominated by IL-10, Transforming growth factor (TGF)-β, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22). This review brews the complexity of the situation during infectious diseases by stressing on this continuum between M1-like and M2-like extremes. We first discuss the basic biology of macrophage polarization, function, and role in the inflammatory process and its resolution. Secondly, we discuss the relevance of the macrophage polarization continuum during infectious and neglected diseases, and the possibility to interfere with such activation states as a promising therapeutic strategy in the treatment of such diseases.
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Cites
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Macrophage Polarization in Physiological and Pathological Pregnancy
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Anderson, N. R., Minutolo, N. G., Gill, S., & Klichinsky, M. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2990 · Cited by 698
Design of therapeutic biomaterials to control inflammation
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Metadata
- Authors
- Atri, C., Guerfali, F. Z., & Laouini, D.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-06-19
- Volume
- 19
- Issue
- 6
- Pages
- 1801
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2807906301
- Cited by
- 1,290
- References
- 81
- FWCI
- 35.58
- Type
- journal article
- Language
- en
- Open access
- gold
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