Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives
Open accessAbstract
Melatonin is a tryptophan-derived molecule with pleiotropic activities which is produced in all living organisms. This “sleep” hormone is a free radical scavenger, which activates several anti-oxidative enzymes and mechanisms. Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This indoleamine can protect the organs against a variety of damaging agents via multiple signaling. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett’s esophagus. Since both of these condition are also identified as major risk factors for esophageal carcinoma, we provide some experimental and clinical evidence that supplementation therapy with melatonin could be useful in esophageal injury by protecting various animal models and patients with GERD from erosions, Barrett’s esophagus and neoplasia. The physiological aspects of the synthesis and release of this indoleamine in the gut, including its release into portal circulation and liver uptake is examined. The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed.
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Melatonin has been attributed to increasing the tone of the lower esophageal sphincter with the increased production of gastrin.
“With the increased production of gastrin, melatonin has also been attributed to increasing the tone of the lower esophageal sphincter [42].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [42]
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Gastroduodenal Microcirculatory Response to Luminal Acid
Kaunitz, J. D., Tanaka, S., & Akiba, Y. (2006) · Springer eBooks · doi:10.1007/4-431-27174-0_10 · Cited by 2 · see citing works
Flagged first, then by citations
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Cited by
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“With the increased production of gastrin, melatonin has also been attributed to increasing the tone of the lower esophageal sphincter [42].”
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Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease
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Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications
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Sorting out the Relationship between Gastroesophageal Reflux Disease and Sleep
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The mechanisms and roles of melatonin in gastrointestinal cancer
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Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer
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Esophageal-gastrointestinal-diaphragmatic murmur - a new objective sign of diaphragmatic hernias
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EFFECTS OF MELATONIN IN DISEASES OF THE DIGESTIVE SYSTEM. LITERATURE REVIEW
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- Authors
- Majka, J., Wierdak, M., Brzozowska, I., Magierowski, M., Szlachcic, A., Wojcik, D., Kwiecien, S., Magierowska, K., Zagajewski, J., & Brzozowski, T.
- Affiliations
- Jagiellonian University (PL)
- Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland
- Corresponding author
- Brzozowski, Tomasz
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-07-13
- Volume
- 19
- Issue
- 7
- Pages
- 2033
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6073539
- OpenAlex
- W2883722502
- Cited by
- 31
- References
- 103
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Uniwersytet Jagielloński Collegium Medicum
- Narodowym Centrum Nauki
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- melatonin, reflux esophagitis, Barrett's esophagus, esophageal adenocarcinoma, gastroesophageal reflux disease, tryptophan, antioxidant activity, free radical scavenging, chronic inflammation, melatonin supplementation
- MeSH terms
- Adenocarcinoma, Animals, Barrett Esophagus, Esophageal Neoplasms, Esophagitis, Peptic, Esophagus, Humans, Melatonin, Models, Biological, Protective Agents
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