The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerate Skin Cell Proliferation
Open accessAbstract
Induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) serve as a unique source for cell therapy. We investigated whether exosomes from iMSCs promote the proliferation of human keratinocytes (HaCaT) and human dermal fibroblasts (HDFs). iPSCs were established from human Wharton’s jelly MSCs and were allowed to differentiate into iMSCs. Exosomes were collected from the culture supernatant of MSCs (MSC-exo) and iMSCs (iMSC-exo), and their characteristics were investigated. Both exosome types possessed basic characteristics of exosomes and were taken up by skin cells in vitro and in vivo. A significant increase in HaCaT proliferation was observed with iMSC-exo, although both exosomes increased the viability and cell cycle progression in HaCaT and HDFs. No significant difference was observed in the closure of wound scratch and the expression of reparative genes between cells treated with the two exosome types. Both exosomes enhanced the secretion of collagen in HaCaT and HDFs; however, an increase in fibronectin level was observed only in HaCaT, and this effect was better with iMSC-exo treatment. Only iMSC-exo increased the phosphorylation of extracellular signal-regulated kinase (ERK)-1/2. Our results indicate that iMSC-exo promote the proliferation of skin cells by stimulating ERK1/2 and highlight the application of iMSCs for producing exosomes.
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Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound
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A Comparative View on Human Somatic Cell Sources for iPSC Generation
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Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake
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Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction
Xu, Q., Xiao, Z., Yang, Q., Yu, T., Deng, X., Chen, N., Huang, Y., Wang, L., Guo, J., & Wang, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100978 · Cited by 77
Lang, H.-L., Zhao, Y.-Z., Xiao, R.-J., Sun, J., Chen, Y., Hu, G.-W., & Xu, G.-H. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.350205 · Cited by 33
Innovative Approaches and Advances for Hair Follicle Regeneration
Zheng, W., & Xu, C.-H. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00028 · Cited by 32
Buitrago, J. C., Morris, S. L., Backhaus, A., Kaltenecker, G., Kaipa, J. M., Girard, C., Schneider, S., & Gruber, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-75956-3 · Cited by 21
Mesenchymal Stem Cells for Cutaneous Wound Healing
Camões, S. P., Santos, J. M., Carvalho, F., & Miranda, J. P. (2020) · Learning Materials in Biosciences · doi:10.1007/978-3-030-43939-2_13 · Cited by 6
Metadata
- Authors
- Kim, S., Lee, S., Kim, H., & Kim, T.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-10-11
- Volume
- 19
- Issue
- 10
- Pages
- 3119
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2896130761
- Cited by
- 215
- References
- 6
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- gold
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