Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction
Open accessAbstract
A life-threatening illness that poses a serious threat to human health is myocardial infarction. It may result in a significant number of myocardial cells dying, dilated left ventricles, dysfunctional heart function, and ultimately cardiac failure. Based on the development of emerging biomaterials and the lack of clinical treatment methods and cardiac donors for myocardial infarction, hydrogels with good compatibility have been gradually applied to the treatment of myocardial infarction. Specifically, based on the three processes of pathophysiology of myocardial infarction, we summarized various types of hydrogels designed for myocardial tissue engineering in recent years, including natural hydrogels, intelligent hydrogels, growth factors, stem cells, and microRNA-loaded hydrogels. In addition, we also describe the heart patch and preparation techniques that promote the repair of MI heart function. Although most of these hydrogels are still in the preclinical research stage and lack of clinical trials, they have great potential for further application in the future. It is expected that this review will improve our knowledge of and offer fresh approaches to treating myocardial infarction.
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Over the past ten years, more than 30 studies have explored dLECM-based hydrogels in liver regeneration.
“In fact, over the past ten years, more than 30 studies have explored dLECM-based hydrogels in liver regeneration.”
From From scaffold to function: A systematic review on dLECM-based hydrogels for liver tissue engineering — Fabrication, properties, and translational applications (2026) · cites this paper as [12]
The cardiac tissue engineering section discusses decellularized extracellular matrix hydrogels for myocardial repair, not liver regeneration. Searches for dLECM-based hydrogels, liver regeneration, and the claimed count of more than 30 studies found no passage addressing the claim in our copy; the retrieved passages have no page numbers. (LLM, conf=0.74)
Experimental — accuracy not yet measureddLECM hydrogels can help maintain hepatocyte function in culture, boost angiogenesis, reduce fibrosis, and support the formation of organoid-like structures.
“Results show these hydrogels can help maintain hepatocyte function in culture, boost angiogenesis, reduce fibrosis, and even support the formation of organoid-like structures.”
From From scaffold to function: A systematic review on dLECM-based hydrogels for liver tissue engineering — Fabrication, properties, and translational applications (2026) · cites this paper as [12]
The Responsive hydrogel section reports reduced myocardial fibrosis with a dECM-containing hydrogel, but it does not identify the material as dLECM. Searches for dLECM, hepatocyte function, and organoid-like structures found no passage addressing the claimed liver-culture outcomes; the paper's angiogenesis findings concern cardiac hydrogels. (LLM, conf=0.77)
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- Authors
- Xu, Q., Xiao, Z., Yang, Q., Yu, T., Deng, X., Chen, N., Huang, Y., Wang, L., Guo, J., & Wang, J.
- Affiliations
- Jinan University (CN)
- University of California, Davis (US)
- Corresponding author
- Wang, Lihong
- Guo, Jun
- Wang, Jinghao
- Venue
- Materials Today Bio
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 25
- Pages
- 100978
- ISSN
- 2590-0064 (ISSN-L)
- PMC
- PMC10907859
- OpenAlex
- W4391787791
- Cited by
- 77
- References
- 252
- Citations by year
- 2026: 32 · 2025: 36 · 2024: 9
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Today Bio (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- myocardial infarction, hydrogels, cardiac tissue engineering, cardiac regeneration, natural hydrogels, stimuli-responsive hydrogels, growth factor delivery, stem cell delivery, biomaterials, cardiac repair
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