Melatonin and Its Metabolites Ameliorate UVR-Induced Mitochondrial Oxidative Stress in Human MNT-1 Melanoma Cells
Open accessAbstract
Melatonin (Mel) is the major biologically active molecule secreted by the pineal gland. Mel and its metabolites, 6-hydroxymelatonin (6(OH)Mel) and 5-methoxytryptamine (5-MT), possess a variety of functions, including the scavenging of free radicals and the induction of protective or reparative mechanisms in the cell. Their amphiphilic character allows them to cross cellular membranes and reach subcellular organelles, including the mitochondria. Herein, the action of Mel, 6(OH)Mel, and 5-MT in human MNT-1 melanoma cells against ultraviolet B (UVB) radiation was investigated. The dose of 50 mJ/cm2 caused a significant reduction of cell viability up to 48%, while investigated compounds counteracted this deleterious effect. UVB exposure increased catalase activity and led to a simultaneous Ca++ influx (16%), while tested compounds prevented these disturbances. Additional analysis focused on mitochondrial respiration performed in isolated mitochondria from the liver of BALB/cJ mice where Mel, 6(OH)Mel, and 5-MT significantly enhanced the oxidative phosphorylation at the dose of 10−6 M with lower effects seen at 10−9 or 10−4 M. In conclusion, Mel, 6(OH)Mel and 5-MT protect MNT-1 cells, which express melatonin receptors (MT1 and MT2) against UVB-induced oxidative stress and mitochondrial dysfunction, including the uncoupling of oxidative phosphorylation.
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Melatonin metabolites 6-hydroxymelatonin and 5-methoxytryptamine increase mitochondrial respiration in human MNT-1 melanoma cells at micromolar concentration.
“A micromolar concentration is sufficient to significantly increase mitochondrial respiration in human MNT-1 melanoma cells [73].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [73]
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Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor
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Self-citationProtective Role of Melatonin and Its Metabolites in Skin Aging
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Self-citationRevisiting the role of melatonin in human melanocyte physiology: A skin context perspective
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Self-citationCharacterization of serotonin and N ‐acetylserotonin systems in the human epidermis and skin cells
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Endocrine Controls of Skin Aging
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Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT‐1 melanoma cells
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Self-citationMelatonin and the Skin: Current Progress and Perspectives for Human Health
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Melatonin’s Antineoplastic Potential Against Glioblastoma
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Detection of Serotonin, Melatonin, and Their Metabolites in Honey
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Self-citationTheophylline exerts complex anti‐ageing and anti‐cytotoxicity effects in human skin ex vivo
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Melatonin and its mechanism of action in the female reproductive system and related malignancies
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Metabolism of Lumisterol2 by CYP27A1
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PHARMACOLOGICAL APPLICATIONS OF MELATONIN
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- Authors
- Kleszczyński, K., Bilska, B., Stegemann, A., Flis, D. J., Ziolkowski, W., Pyza, E., Luger, T. A., Reiter, R. J., Böhm, M., & Slominski, A. T.
- Affiliations
- University of Münster (DE)
- Jagiellonian University (PL)
- Department of Bioenergetics and Nutrition, Gdańsk University of Physical Education and Sport, Górski Str. 1, 80-336 Gdańsk, Poland
- The University of Texas at San Antonio Health Science Center (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Kleszczyński, Konrad
- Slominski, Andrzej T.
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-28
- Volume
- 19
- Issue
- 12
- Pages
- 3786
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6320988
- OpenAlex
- W2902234339
- Cited by
- 54
- References
- 94
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 9
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (KL2900/2-1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- melatonin, 6-hydroxymelatonin, 5-methoxytryptamine, UV-B radiation, melanoma, mitochondrial oxidative stress, mitochondrial dysfunction, oxidative phosphorylation, catalase activity, calcium influx, melatonin receptors, photoprotection
- MeSH terms
- Animals, Calcium, Catalase, Cell Survival, Humans, Liver, Melanoma, Melatonin, 5-Methoxytryptamine, Mice, Inbred BALB C, Mitochondria, Oxidative Phosphorylation, Ultraviolet Rays, Oxidative Stress, Cell Line, Tumor
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