The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Emerging Strategies of Cancer Therapy Based on Ferroptosis
Open accessAbstract
Ferroptosis, a new form of regulated cell death that is iron‐ and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy. However, the published ferroptosis‐related reviews have mainly focused on the mechanisms and pathways of ferroptosis, which motivated this contribution to bridge the gap between biological significance and material design. Therefore, it is timely to summarize the previous efforts on the emerging strategies for inducing ferroptosis and shed light on future directions for using such a tool to fight against cancer. Here, the current strategies of cancer therapy based on ferroptosis will be elaborated, the design considerations and the advantages and limitations are highlighted, and finally a future perspective on this emerging field is given.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Ferroptosis: process and function
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Modulation of oxidative stress as an anticancer strategy
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Cited by
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Self-citationRecent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Role of GPX4 in ferroptosis and its pharmacological implication
Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.014 · Cited by 1,520
The development of the concept of ferroptosis
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Mitochondria regulation in ferroptosis
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Metadata
- Authors
- Shen, Z., Song, J., Yung, B. C., Zhou, Z., Wu, A., & Chen, X.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-01-22
- Volume
- 30
- Issue
- 12
- Pages
- e1704007-e1704007
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2786943354
- Cited by
- 740
- References
- 24
- FWCI
- 47.85
- Type
- journal article
- Language
- en
- Open access
- green
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