The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls
Open accessAbstract
Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact of psyllium on faecal microbiota, whose key role in gut physiology is being increasingly recognised. We performed two randomised, placebo-controlled, double-blinded trials comparing 7 days of psyllium with a placebo (maltodextrin) in 8 healthy volunteers and 16 constipated patients respectively. We measured the patients’ gastrointestnal (GI) transit, faecal water content, short-chain fatty acid (SCFA) and the stool microbiota composition. While psyllium supplement had a small but significant effect on the microbial composition of healthy adults (increasing Veillonella and decreasing Subdoligranulum), in constipated subjects there were greater effects on the microbial composition (increased Lachnospira, Faecalibacterium, Phascolarctobacterium, Veillonella and Sutterella and decreased uncultured Coriobacteria and Christensenella) and alterations in the levels of acetate and propionate. We found several taxa to be associated with altered GI transit, SCFAs and faecal water content in these patients. Significant increases in three genera known to produce butyrate, Lachnospira, Roseburia and Faecalibacterium, correlated with increased faecal water. In summary, psyllium supplementation increased stool water and this was associated with significant changes in microbiota, most marked in constipated patients.
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Metadata
- Authors
- Jalanka, J., Major, G., Murray, K., Singh, G., Nowak, A., Kurtz, C., Silos-Santiago, I., Johnston, J. M., de Vos, W. M., & Spiller, R.
- Affiliations
- Nottingham University Hospitals NHS Trust (GB)
- Synlogic (United States) (US)
- Decibel Therapeutics Inc., Boston, MA 02215, USA
- Ironwood Pharmaceuticals (United States) (US)
- Laboratory of Microbiology, Wageningen University, 6708WE Wageningen, The Netherlands
- Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-01-20
- Volume
- 20
- Issue
- 2
- Pages
- 433
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6358997
- OpenAlex
- W2911132895
- Cited by
- 219
- References
- 38
- Citations by year
- 2026: 31 · 2025: 38 · 2024: 43 · 2023: 31 · 2022: 31 · 2021: 23 · 2020: 17 · 2019: 5
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Työväentutkimus Vuosikirja (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- Academy of Finland (0313471-7)
- Ironwood Pharmaceuticals Inc., Cambridge, MA, USA (-)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- psyllium, constipation, gut microbiota, fecal microbiota composition, short-chain fatty acids, gastrointestinal transit, fecal water content, Lachnospira, Faecalibacterium, Roseburia, butyrate, Veillonella, dietary fiber supplementation
- MeSH terms
- Gastrointestinal Microbiome, Adult, Bacteria, Constipation, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Humans, Male, Middle Aged, Phylogeny, Psyllium, Case-Control Studies, Young Adult
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