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Cited by 219Gut microbiota and healthGastrointestinal motility and disordersMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls

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Jalanka, Jonna, Major, Giles, Murray, Kathryn, Singh, Gulzar, Nowak, Adam, Kurtz, Caroline, Silos-Santiago, Inmaculada, Johnston, Jeffrey M., de Vos, Willem M., Spiller, Robin·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20020433PMC PMC6358997
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Abstract

Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact of psyllium on faecal microbiota, whose key role in gut physiology is being increasingly recognised. We performed two randomised, placebo-controlled, double-blinded trials comparing 7 days of psyllium with a placebo (maltodextrin) in 8 healthy volunteers and 16 constipated patients respectively. We measured the patients’ gastrointestnal (GI) transit, faecal water content, short-chain fatty acid (SCFA) and the stool microbiota composition. While psyllium supplement had a small but significant effect on the microbial composition of healthy adults (increasing Veillonella and decreasing Subdoligranulum), in constipated subjects there were greater effects on the microbial composition (increased Lachnospira, Faecalibacterium, Phascolarctobacterium, Veillonella and Sutterella and decreased uncultured Coriobacteria and Christensenella) and alterations in the levels of acetate and propionate. We found several taxa to be associated with altered GI transit, SCFAs and faecal water content in these patients. Significant increases in three genera known to produce butyrate, Lachnospira, Roseburia and Faecalibacterium, correlated with increased faecal water. In summary, psyllium supplementation increased stool water and this was associated with significant changes in microbiota, most marked in constipated patients.

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Figures

Figure 1 Principal co-ordinate analysis (PCoA) of the baseline microbial differences between the two study populations.
Figure 1 Principal co-ordinate analysis (PCoA) of the baseline microbial differences between the two study populations.CC BY · PubMed Central
Figure 2 Microbial changes introduced by the psyllium supplementation to the intestinal microbiota of healthy adults.
Figure 2 Microbial changes introduced by the psyllium supplementation to the intestinal microbiota of healthy adults.CC BY · PubMed Central
Figure 3 Associations between whole gut transit time and bacterial abundance measured from all available data points: (A) relative abundance of genus Sutterella and transit time measure (weighted average position score, Weighted Average Position Score (WAPS) measure 24 h after ingestion of transit markers, smaller number indicates longer transit) in healthy subjects; (B) relative abundance of genus Sutterella and transit (WAPS) measured 48 h after ingestion of transit markers in constipated subjects.
Figure 3 Associations between whole gut transit time and bacterial abundance measured from all available data points: (A) relative abundance of genus Sutterella and transit time measure (weighted average position score, Weighted Average Position Score (WAPS) measure 24 h after ingestion of transit markers, smaller number indicates longer transit) in healthy subjects; (B) relative abundance of genus Sutterella and transit (WAPS) measured 48 h after ingestion of transit markers in constipated subjects.CC BY · PubMed Central
Figure 4 Associations between faecal water content and intestinal genera in constipated subjects at all data points.
Figure 4 Associations between faecal water content and intestinal genera in constipated subjects at all data points.CC BY · PubMed Central
Figure 5 Significant associations between acetate and the abundance of microbial taxa in constipated patients.
Figure 5 Significant associations between acetate and the abundance of microbial taxa in constipated patients.CC BY · PubMed Central
Figure 6 Study outline. The arrows indicate faecal sample collection points.
Figure 6 Study outline. The arrows indicate faecal sample collection points.CC BY · PubMed Central

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Metadata

Authors
Jalanka, J., Major, G., Murray, K., Singh, G., Nowak, A., Kurtz, C., Silos-Santiago, I., Johnston, J. M., de Vos, W. M., & Spiller, R.
Affiliations
  • Nottingham University Hospitals NHS Trust (GB)
  • Synlogic (United States) (US)
  • Decibel Therapeutics Inc., Boston, MA 02215, USA
  • Ironwood Pharmaceuticals (United States) (US)
  • Laboratory of Microbiology, Wageningen University, 6708WE Wageningen, The Netherlands
  • Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, the University of Nottingham, Notts NG7 2UH, UK
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-01-20
Volume
20
Issue
2
Pages
433
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20020433
PMC
PMC6358997
OpenAlex
W2911132895
Cited by
219
References
38
Citations by year
2026: 31 · 2025: 38 · 2024: 43 · 2023: 31 · 2022: 31 · 2021: 23 · 2020: 17 · 2019: 5
FWCI
6.25
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Funders
  • Academy of Finland (0313471-7)
  • Ironwood Pharmaceuticals Inc., Cambridge, MA, USA (-)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
psyllium, constipation, gut microbiota, fecal microbiota composition, short-chain fatty acids, gastrointestinal transit, fecal water content, Lachnospira, Faecalibacterium, Roseburia, butyrate, Veillonella, dietary fiber supplementation
MeSH terms
Gastrointestinal Microbiome, Adult, Bacteria, Constipation, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Humans, Male, Middle Aged, Phylogeny, Psyllium, Case-Control Studies, Young Adult

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