Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator
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Hemp seed (Fructus cannabis) is rich in lignanamides, and initial biological screening tests showed their potential anti-inflammatory and anti-oxidative capacity. This study investigated the possible effects and underlying mechanism of cannabisin F, a hempseed lignanamide, against inflammatory response and oxidative stress in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Cannabisin F suppressed the production and the mRNA levels of pro-inflammatory mediators such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in a concentration-dependent manner in LPS-stimulated BV2 microglia cell. Furthermore, cannabisin F enhanced SIRT1 expression and blocked LPS-induced NF-κB (Nuclear factor kappa B) signaling pathway activation by inhibiting phosphorylation of IκBα (Inhibit proteins of nuclear factor kappaB) and NF-κB p65. And the SIRT1 inhibitor EX527 significantly inhibited the effect of cannabisin F on pro-inflammatory cytokines production, suggesting that the anti-inflammatory effects of cannabisin F are SIRT1-dependent. In addition, cannabisin F reduced the production of cellular reactive oxygen species (ROS) and promoted the expression of Nrf2 (Nuclear factor erythroid-2 related factor 2) and HO-1 (Heme Oxygenase-1), suggesting that the anti-oxidative effects of cannabisin F are related to Nrf2 signaling pathway. Collectively, these results suggest that the neuro-protection effect of cannabisin F against LPS-induced inflammatory response and oxidative stress in BV2 microglia cells involves the SIRT1/NF-κB and Nrf2 pathway.
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Pretreatment of BV2 cells with 15 μM cannabisin F significantly reduces IL-6 and TNF-α production induced by LPS (100 ng/mL) at both protein and mRNA levels, in a dose-dependent manner.
“The pretreatment of BV2 cells with doses of 15 μM of cannabisin F significantly reduced IL-6 and TNF-α production induced by LPS (100 ng/mL), at both protein and mRNA levels, and in a dose-dependent manner [89].”
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Cites
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,578 · see citing works
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works
Microglial priming in neurodegenerative disease
Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works
Proinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094 · see citing works
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,029 · see citing works
Kauppinen, A., Suuronen, T., Ojala, J. O., Kaarniranta, K., & Salminen, A. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.06.007 · Cited by 1,001 · see citing works
Hempseed as a nutritional resource: An overview
Callaway, J. C. (2004) · Euphytica · doi:10.1007/s10681-004-4811-6 · Cited by 910 · see citing works
Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581 · see citing works
Rajendrasozhan, S., Yang, S.-R., Kinnula, V. L., & Rahman, I. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1269oc · Cited by 520 · see citing works
de Vries, H. E., Witte, M. E., Hondius, D., Rozemüller, A. J. M., Drukarch, B., Hoozemans, J. J. M., & van Horssen, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.001 · Cited by 432 · see citing works
Physicochemical and Functional Properties of Hemp ( <i>Cannabis sativa</i> L.) Protein Isolate
Tang, C.-H., Ten, Z., Wang, X.-S., & Yang, X.-Q. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0619176 · Cited by 405 · see citing works
Catorce, M. N., & Gevorkian, G. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151204122017 · Cited by 361 · see citing works
Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease
Taylor, J. M., Main, B. S., & Crack, P. J. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.016 · Cited by 303 · see citing works
Shah, S. A., Khan, M., Jo, M. H., Jo, M. G., Amin, F. U., & Kim, M. O. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12588 · Cited by 242 · see citing works
Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?
Witte, M. E., Geurts, J. J. G., de Vries, H. E., van der Valk, P., & van Horssen, J. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.014 · Cited by 236 · see citing works
Nutraceutical potential of hemp (Cannabis sativa L.) seeds and sprouts
Frassinetti, S., Moccia, E., Caltavuturo, L., Gabriele, M., Longo, V. G., Bellani, L., Giorgi, G., & Giorgetti, L. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.04.078 · Cited by 232 · see citing works
Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
Zhang, T., Berrocal, J. G., Frizzell, K. M., Gamble, M. J., DuMond, M. E., Krishnakumar, R., Yang, T., Sauve, A. A., & Kraus, W. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016469 · Cited by 230 · see citing works
la Paz, S. M., Marín‐Aguilar, F., García, M. D., & Fernández, Á. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404278q · Cited by 209 · see citing works
Foresti, R., Bains, S. K., Pitchumony, T. S., Brás, L. E. D. C., Drago, F., Dubois‐Randé, J., Bucolo, C., & Motterlini, R. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.010 · Cited by 176 · see citing works
Efficacy of a Chinese Herbal Proprietary Medicine (Hemp Seed Pill) for Functional Constipation
Cheng, C. W., Bian, Z., Zhu, L.-X., Wu, J. C., & Sung, J. J. �. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.305 · Cited by 174 · see citing works
SIRT1: new avenues of discovery for disorders of oxidative stress
Chong, Z. Z., Shang, Y. C., Wang, S., & Maiese, K. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.648926 · Cited by 163 · see citing works
Self-citationYan, X., Tang, J., dos Santos Passos, C., Nurisso, A., Simões-Pires, C. A., Ji, M., Lou, H., & Fan, P. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05282 · Cited by 160 · see citing works
Self-citationShinozaki, S., Chang, K., Sakai, M., Shimizu, N., Yamada, M., Tanaka, T., Nakazawa, H., Ichinose, F., Yamada, Y., Ishigami, A., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005375 · Cited by 140 · see citing works
Zhou, Y., Wang, S., Lou, H., & Fan, P. (2017) · Phytochemistry Letters · doi:10.1016/j.phytol.2017.11.013 · Cited by 103 · see citing works
Self-citationLuo, Q., Yan, X., Bobrovskaya, L., Ji, M., Yuan, H., Lou, H., & Fan, P. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2923-7 · Cited by 90 · see citing works
Self-citationLim, J. L., Wilhelmus, M. M. M., de Vries, H. E., Drukarch, B., Hoozemans, J. J. M., & van Horssen, J. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1338-z · Cited by 83 · see citing works
Yakovleva, T., Bazov, I., Watanabe, H., Hauser, K. F., & Bakalkin, G. Y. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.019 · Cited by 78 · see citing works
Wun, Z.-Y., Lin, C., Huang, W., Huang, Y., Xu, P.-Y., Chang, W., Wu, S., & Liou, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.072 · Cited by 35 · see citing works
Dietary hempseed reduces platelet aggregation
Richard, M. N., Ganguly, R., Steigerwald, S. N., Al-Khalifa, A., & Pierce, G. N. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02327.x · Cited by 35 · see citing works
Luo, J., Yin, J.-H., Wu, H., & Wei, Q. (2003) · PubMed · Cited by 33 · see citing works
Cannabinoids in Microglia: A New Trick for Immune Surveillance and Neuroprotection
Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.004 · Cited by 26 · see citing works
The effect of different extractants on lead desorption from a natural mineral
Đolić, M. B., Rajakovic-Ognjanovic, V. N., Marković, J., Janković-Mandić, L., Mitrić, M. N., Onjia, A. E., & Rajaković, L. V. (2014) · Applied Surface Science · doi:10.1016/j.apsusc.2014.10.112 · Cited by 15 · see citing works
The effect of different extractants from Hemp seed in mice with experimental Alzheimer's disease
Zhenmei, L., Linmei, C., Zimin, L., & Xia, X. (2016) · Zhongyao Yaoli Yulinchuang · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Farinon, B., Molinari, R., Costantini, L., & Merendino, N. (2020) · Nutrients · doi:10.3390/nu12071935 · Cited by 473 · see citing works
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
Stasiłowicz-Krzemień, A., Tomala, A., Podolak, I., & Cielecka‐Piontek, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020778 · Cited by 105 · see citing works
Bioactive Compounds in Edible Oils and Their Role in Oxidative Stress and Inflammation
Mazzocchi, A., Cosmi, V. D., Risé, P., Milani, G. P., Turolo, S., Syrén, M., Sala, A., & Agostoni, C. V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659551 · Cited by 92 · see citing works
Sana, S., Reddy, V. G., Reddy, T. S., Tokala, R., Kumar, R., Bhargava, S. K., & Shankaraiah, N. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104765 · Cited by 78 · see citing works
Neuroprotective protein hydrolysates from hemp ( Cannabis sativa L.) seeds
Rodríguez-Martín, N. M., Toscano, R., Villanueva-Lazo, A., Pedroche, J., Millán, F., la Paz, S. M., & Millán-Linares, M. C. (2019) · Food & Function · doi:10.1039/c9fo01904a · Cited by 76 · see citing works
Leonard, W., Zhang, P., Ying, D., Xiong, Y., & Fang, Z. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128606 · Cited by 73 · see citing works
Rodriguez-Martin, N. M., Montserrat-de la Paz, S., Toscano, R., Grao-Cruces, E., Villanueva, A., Pedroche, J., Millan, F., & Millan-Linares, M. C. (2020) · Biomolecules · doi:10.3390/biom10050803 · Cited by 61 · see citing works
Lignanamides: sources, biosynthesis and potential health benefits – a minireview
Leonard, W., Zhang, P., Ying, D., & Fang, Z. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1759025 · Cited by 59 · see citing works
Nigro, E., Crescente, G., Formato, M., Pecoraro, M. T., Mallardo, M., Piccolella, S., Daniele, A., & Pacifico, S. (2020) · Molecules · doi:10.3390/molecules25051049 · Cited by 56 · see citing works
Jia, Y., Zhang, D., Yin, H., Li, H., Du, J., & Bao, H. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03303-3 · Cited by 52 · see citing works
Cruz‐Chamorro, I., Santos‐Sánchez, G., Bollati, C., Bartolomei, M., Li, J., Arnoldi, A., & Lammi, C. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07520 · Cited by 52 · see citing works
Michailidis, D., Angelis, A., Nikolaou, P., Mitakou, S., & Skaltsounis, A. L. (2021) · Molecules · doi:10.3390/molecules26030731 · Cited by 49 · see citing works
Selected Seeds as Sources of Bioactive Compounds with Diverse Biological Activities
Sławińska, N., & Olas, B. (2022) · Nutrients · doi:10.3390/nu15010187 · Cited by 50 · see citing works
Meng, F., Yu, W., Duan, W., Wang, T., & Liu, Y. (2019) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12528 · Cited by 45 · see citing works
Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100176 · Cited by 41 · see citing works
Lim, X. Y., Tan, T. Y. C., Rosli, S. H. M., Sa’at, M. N. F., Ali, S. S., & Mohamed, A. F. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245471 · Cited by 37 · see citing works
Bukowska, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312738 · Cited by 38 · see citing works
A review of medicine and food homology on traditional Chinese medicine as functional food
Law, S., & Au, D. C. T. (2025) · Food & medicine homology. · doi:10.26599/fmh.2026.9420091 · Cited by 33 · see citing works
Industrial Hemp As a Multi-Purpose Crop: Last Achievements and Research in 2018−2023
Dudziec, P., Warmiński, K., & Stolarski, M. J. (2024) · Journal of Natural Fibers · doi:10.1080/15440478.2024.2369186 · Cited by 31 · see citing works
Ubeed, H. M. S. A., Brennan, C. S., Schanknecht, E., Alsherbiny, M. A., Saifullah, M., Nguyen, K. Q., & Vuong, Q. V. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16116 · Cited by 30 · see citing works
Zhang, D., Jia, Y., Sun, X., Li, H., Yin, M., Li, H., Dai, L., Han, L., Wang, L., Qian, M., et al. (2022) · Journal of Immunology Research · doi:10.1155/2022/3002304 · Cited by 27 · see citing works
Qin, X., Chen, J., Zhang, G., Li, C., Zhu, J., Xue, H., Li, J., Guan, T., Zheng, H., Liu, Y., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01315 · Cited by 23 · see citing works
Antioxidant Properties of Hemp Proteins: From Functional Food to Phytotherapy and Beyond
Zhang, J., Griffin, J., Li, Y., Wang, D., & Wang, W. (2022) · Molecules · doi:10.3390/molecules27227924 · Cited by 23 · see citing works
Sirtuins functions in central nervous system cells under neurological disorders
Yan, J., Tang, X., Zhou, Z., Zhang, J., Zhao, Y., Li, S., & Luo, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.886087 · Cited by 22 · see citing works
Xu, P., Yue, X.-J., Yuan, X., & Zhao, B. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103293 · Cited by 22 · see citing works
Boucher, R., Germain, H., & Desgagné-Penix, I. (2025) · Plants · doi:10.3390/plants14091372 · Cited by 23 · see citing works
Siracusa, L., Ruberto, G., & Cristino, L. (2023) · Molecules · doi:10.3390/molecules28083387 · Cited by 24 · see citing works
Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia
Fangma, Y., Wan, H., Shao, C., Jin, L., & He, Y. G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01288-3 · Cited by 20 · see citing works
FGF21 confers neuroprotection in Parkinson’s disease by activating the FGFR1-sirt1 pathway
Liu, T., & Wei, J. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00807-6 · Cited by 17 · see citing works
Leonard, W., Xiong, Y., Zhang, P., Ying, D., & Fang, Z. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04500 · Cited by 15 · see citing works
Padilla-González, G. F., Rosselli, A., Sadgrove, N. J., Cui, M., & Simmonds, M. S. J. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1114398 · Cited by 16 · see citing works
Gagné, V., Merindol, N., Boucher, R., Boucher, N., & Desgagné-Penix, I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1465136 · Cited by 19 · see citing works
Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies
Duarte, G. M., de Araújo, F. E. A., da Rocha, J. M. C., Neta, F. I., do Rêgo, A. C. M., Araújo-Filho, I., Pinheiro, F. I., de Azevedo, E. P., Cobucci, R. N., & Gúzen, F. P. (2023) · Nutrients · doi:10.3390/nu15112502 · Cited by 13 · see citing works
An In Vitro Verification of the Effects of Paeoniflorin on Lipopolysaccharide‐Exposed Microglia
Chen, Q., Liu, Y., Zhang, Y., Jiang, X., Zhang, Y., & Asakawa, T. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/5801453 · Cited by 13 · see citing works
Wang, S., Liu, Y., Li, X., Algradi, A. M., Jiang, H., Sun, Y., Guan, W., Pan, J., Kuang, H., & Yang, B. (2021) · Molecules · doi:10.3390/molecules26195946 · Cited by 12 · see citing works
Self-citationHealth-Promoting Opportunities of Hemp Hull: The Potential of Bioactive Compounds
van Klinken, B. J., Stewart, M., Kalgaonkar, S., & Chae, L. (2024) · Journal of Dietary Supplements · doi:10.1080/19390211.2024.2308264 · Cited by 12 · see citing works
Hemp (Cannabis sativa L.) seeds nutritional aspects and food production perspectives: A review
Capcanari, T., Covaliov, E., & Negoița, C. (2024) · Food systems · doi:10.21323/2618-9771-2024-7-1-52-58 · Cited by 13 · see citing works
Sun, J., Tong, L., Tu, P., Chen, L.-L., Xu, X., Song, Y., Yang, X., Guo, Z.-B., Zou, X., Sun, C.-X., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140459 · Cited by 11 · see citing works
Kaçar, Ö., Kose, T., & Kaçar, H. K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1669375 · Cited by 9 · see citing works
Cavallero, A., Chelucci, E., Chiellini, C., & Gabriele, M. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105138 · Cited by 8 · see citing works
Galiano, F. J. D., Morales, M. M., & Fernández‐Alba, A. R. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13325 · Cited by 7 · see citing works
Bu, S., Ji, J., Yang, M. J., Sun, J., Zhang, J., Qian, S., Lou, H., & Fan, P. (2024) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2024.100051 · Cited by 7 · see citing works
Self-citationChen, Z., Hao, S., He, Z., Liu, J., Zhao, J., Chen, C., Jia, G., & Chen, H. (2023) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.117661 · Cited by 7 · see citing works
Kaminsky, N., Hubert, J., Guerin, C., Mazlani, M., Kotland, A., Pozzobon, V., Marant, B., Mailhac, H., & Poigny, S. (2024) · Molecules · doi:10.3390/molecules29235792 · Cited by 7 · see citing works
Wu, D., Liu, Y., Guan, W., Pan, J., Kuang, H., & Yang, B. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201047 · Cited by 6 · see citing works
Zhang, S., Huang, J., Fu, J., Yu, Q., Zhang, X., Yao, X., Zhu, L., & Liu, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00242 · Cited by 7 · see citing works
Briglia, M., Allia, F., Avola, R., Signorini, C., Cardile, V., Romano, G. L., Giurdanella, G., Malaguarnera, R., Bellomo, M., & Graziano, A. C. E. (2024) · Nutrients · doi:10.3390/nu16183114 · Cited by 7 · see citing works
Comprehensive review on cannabis seed phenolic compounds from extraction to functional applications
Benkirane, C., Ati, R. E., Abid, M., Nkengurutse, J., Serghini‐Caid, H., Elamrani, A., & Mansouri, F. (2026) · Journal of Cannabis Research · doi:10.1186/s42238-026-00401-3 · Cited by 5 · see citing works
Obeme-Nmom, J. I., & Udenigwe, C. C. (2024) · Current Opinion in Food Science · doi:10.1016/j.cofs.2024.101174 · Cited by 5 · see citing works
Magalhães, P., Domingues, M. R., & Alves, E. (2021) · Current Nutrition & Food Science · doi:10.2174/1573401317666210624142643 · Cited by 4 · see citing works
Mallardo, M., Pacifico, S., Piccolella, S., Meo, I. D., Rizzo, M. R., Daniele, A., & Nigro, E. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1374626 · Cited by 4 · see citing works
Luo, H., Zhao, S., Zi, J., Hu, Y., Yao, Y., & Xiong, J. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.10.007 · Cited by 4 · see citing works
Hemp Hay (Cannabis sativa L.) in Grazing Goats’ Diet: Effects on Oxidative and Inflammatory Status
Zicarelli, F., Lotito, D., Iommelli, P., Amato, R., Mahayri, T. M., Musco, N., Pacifico, E., Infascelli, F., Tudisco, R., Moniello, G., et al. (2025) · Animals · doi:10.3390/ani15030364 · Cited by 4 · see citing works
Yang, M., Ji, J., Bu, S., Sun, J., Zhang, Y., Hu, X., Zhang, J., Lou, H., & Fan, P. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100573 · Cited by 3 · see citing works
Self-citationEl-Mernissi, R., Menyiy, N. E., Metouekel, A., Zouhri, A., El-Mernissi, Y., Siddique, F., Nadeem, S., Amhamdi, H., Abboussi, O., Alsahli, A. A., et al. (2024) · Open Life Sciences · doi:10.1515/biol-2022-1024 · Cited by 3 · see citing works
Yang, X., Wang, S., Fang, J., Sun, Y., Cheng, Z., & Cao, X. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150235 · Cited by 3 · see citing works
Self-citationPhenylpropanoids from Solanum capsicoides and their anti-inflammatory activity
Wang, H., Liu, Y., Jang, Y.-K., Wang, S., Li, X., Pan, J., Guan, W., Algradi, A. M., Kuang, H., & Yang, B. (2022) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2022.2066529 · Cited by 3 · see citing works
Self-citationLignanamides from the Roots of Metternichia macrocalyx and Their Anti-inflammatory Activity
Brito, T. A. D. M., de Albuquerque, A. C. F., dos Santos, F. M., Loureiro, P. B. A., Gadelha, F. A. A. F., Sobral, M. V., Cardoso, D., Velozo, E. D. S., Tavares, J. F., Abreu, L. S., et al. (2024) · ACS Omega · doi:10.1021/acsomega.4c07336 · Cited by 2 · see citing works
Wise, K., Selby-Pham, S. N. B., & Selby‐Pham, J. (2025) · New Zealand Journal of Crop and Horticultural Science · doi:10.1080/01140671.2025.2519571 · Cited by 2 · see citing works
Reyes-Flores, S., Pereira, T. S. S., Abioye, R. O., & Udenigwe, C. C. (2025) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.5c00110 · Cited by 2 · see citing works
El-Mernissi, R., Menyiy, N. E., Zouhri, A., El-Mernissi, Y., Metouekel, A., Siddique, F., Mughram, M. H. A., Temesgen, D., Alanzi, A. R., Khalid, M., et al. (2026) · Open Life Sciences · doi:10.1515/biol-2025-1211 · Cited by 2 · see citing works
Oomah, B. D. (2022) · Wiley eBooks · doi:10.1002/9781119804055.ch9 · Cited by 1 · see citing works
Wu, S., Wang, L., Li, H. B., Li, G. L., Guo, C. Y., & Zhang, J. (2021) · Research Square · doi:10.21203/rs.3.rs-242208/v1
Cytotoxic stilbenoid from the leaves and stems of Cassia nodosa
Sun, Q., Yu, L., Shao, C., Qing, C., Aisa, H. A., Zhan, R., & Chen, Y. (2025) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2025.105081
Brambilla, G., Belli, G., Paggi, A., Morini, L., & Visoná, S. D. (2026) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlag049
Thiry, M., Sergeant, K., Legay, S., Iken, M., Renaut, J., Lutts, S., & Guerriero, G. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1923697 · Cited by 1 · see citing works
- Authors
- Wang, S., Luo, Q., & Fan, P.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Fan, Peihong
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-01-25
- Volume
- 20
- Issue
- 3
- Pages
- 507
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6387064
- OpenAlex
- W2914618279
- Cited by
- 66
- References
- 39
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 18 · 2023: 6 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 2
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81473323)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- hemp seeds, Cannabis sativa, lignanamides, anti-inflammatory activity, oxidative stress, microglia, lipopolysaccharide, SIRT1, NF-κB signaling, Nrf2/HO-1 pathway, inflammatory cytokines, neuroprotection, EX527
- MeSH terms
- Animals, Anti-Inflammatory Agents, Carbazoles, Cell Line, Cell Survival, Gene Expression Regulation, Lipopolysaccharides, Nitric Oxide, Phenols, Phosphorylation, Molecular Structure, Signal Transduction, NF-kappa B, Microglia, Oxidative Stress, NF-E2-Related Factor 2, Mice, Sirtuin 1
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