The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Adiponectin—Consideration for its Role in Skeletal Muscle Health
Open accessAbstract
Adiponectin regulates metabolism through blood glucose control and fatty acid oxidation, partly mediated by downstream effects of adiponectin signaling in skeletal muscle. More recently, skeletal muscle has been identified as a source of adiponectin expression, fueling interest in the role of adiponectin as both a circulating adipokine and a locally expressed paracrine/autocrine factor. In addition to being metabolically responsive, skeletal muscle functional capacity, calcium handling, growth and maintenance, regenerative capacity, and susceptibility to chronic inflammation are all strongly influenced by adiponectin stimulation. Furthermore, physical exercise has clear links to adiponectin expression and circulating concentrations in healthy and diseased populations. Greater physical activity is generally related to higher adiponectin expression while lower adiponectin levels are found in inactive obese, pre-diabetic, and diabetic populations. Exercise training typically restores plasma adiponectin and is associated with improved insulin sensitivity. Thus, the role of adiponectin signaling in skeletal muscle has expanded beyond that of a metabolic regulator to include several aspects of skeletal muscle function and maintenance critical to muscle health, many of which are responsive to, and mediated by, physical exercise.
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“Effects of acute exercise on ApN parameters are inconsistent, if any [77,78].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [77]
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“In parallel to imposed bouts of exercise training, circulating ApN was linked to physical activity behavior in large human cross-sectional studies, where greater physical activity was generally associated with higher ApN levels [77,85,86].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [77]
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- Hara, 2006, Measurement of the High-Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin, Cardiovasc. Metab. Risk, 29, 1357
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Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases
Choi, H. M., Doss, H. M., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041219 · Cited by 536
Metabolic changes in aging humans: current evidence and therapeutic strategies
Palmer, A. K., & Jensen, M. D. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158451 · Cited by 383
Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 245
Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications
Begum, M., Choubey, M., Tirumalasetty, M. B., Arbee, S., Mohib, M. M., Wahiduzzaman, M., Mamun, M. A., Uddin, M. B., & Mohiuddin, M. S. (2023) · Life · doi:10.3390/life13112213 · Cited by 138
Skeletal muscle adiponectin induction in obesity and exercise
Martínez-Huenchullán, S., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., McLennan, S. V., & Twigg, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154008 · Cited by 119
Metadata
- Authors
- Krause, M. P., Milne, K. J., & Hawke, T. J.
- Affiliations
- University of Windsor (CA)
- McMaster University (CA)
- Corresponding author
- Krause, Matthew P.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-03-27
- Volume
- 20
- Issue
- 7
- Pages
- 1528
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6480271
- OpenAlex
- W2924066250
- Cited by
- 121
- References
- 121
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 15 · 2023: 11 · 2022: 32 · 2021: 21 · 2020: 11 · 2019: 5
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-05073)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, skeletal muscle, adipokines, paracrine signaling, muscle regeneration, chronic inflammation, physical activity, insulin sensitivity, obesity, diabetes mellitus, blood glucose regulation, fatty acid oxidation
- MeSH terms
- Autophagy, Humans, Protein Processing, Post-Translational, Regeneration, Exercise, Muscle, Skeletal, Adiponectin
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