Cited by 123Adipokines, Inflammation, and Metabolic DiseasesMuscle Physiology and DisordersAdipose Tissue and Metabolism

The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.

Adiponectin—Consideration for its Role in Skeletal Muscle Health

Open access

Krause, Matthew P., Milne, Kevin J., Hawke, Thomas J.·2019·International Journal of Molecular Sciences

DOI 10.3390/ijms20071528PMC PMC6480271

Open this paper in CoChat — free account Open PDF

Abstract

Adiponectin regulates metabolism through blood glucose control and fatty acid oxidation, partly mediated by downstream effects of adiponectin signaling in skeletal muscle. More recently, skeletal muscle has been identified as a source of adiponectin expression, fueling interest in the role of adiponectin as both a circulating adipokine and a locally expressed paracrine/autocrine factor. In addition to being metabolically responsive, skeletal muscle functional capacity, calcium handling, growth and maintenance, regenerative capacity, and susceptibility to chronic inflammation are all strongly influenced by adiponectin stimulation. Furthermore, physical exercise has clear links to adiponectin expression and circulating concentrations in healthy and diseased populations. Greater physical activity is generally related to higher adiponectin expression while lower adiponectin levels are found in inactive obese, pre-diabetic, and diabetic populations. Exercise training typically restores plasma adiponectin and is associated with improved insulin sensitivity. Thus, the role of adiponectin signaling in skeletal muscle has expanded beyond that of a metabolic regulator to include several aspects of skeletal muscle function and maintenance critical to muscle health, many of which are responsive to, and mediated by, physical exercise.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms20071528

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Proposed relationships between adiponectin, exercise, and skeletal muscle function. Multiple isoforms including the proteolytically cleaved globular isoform signal to tissue including skeletal muscle, satellite cells, myoblasts, and differentiated myotubes. Physical exercise generally stimulates increases in adiponectin expression and signaling. Skeletal muscle health is ultimately improved with sufficient adiponectin signaling via improved cellular functions such as autophagy and regeneration and suppression of inflammation, endoplasmic reticulum (ER) stress, and proteolysis. Solid arrows represent relationships, effects, or interactions that are clearly defined in the literature. Broken arrows with “?” represent relationships, effects, or interactions that are not clearly defined in the literature.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,782

Show all 121 references

Research works printed but not linked: 1

Hara, 2006, Measurement of the High-Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin, Cardiovasc. Metab. Risk, 29, 1357

Sorted by citations

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases
Choi, H. M., Doss, H. M., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041219 · Cited by 536
Metabolic changes in aging humans: current evidence and therapeutic strategies
Palmer, A. K., & Jensen, M. D. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158451 · Cited by 383
Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 245
Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications
Begum, M., Choubey, M., Tirumalasetty, M. B., Arbee, S., Mohib, M. M., Wahiduzzaman, M., Mamun, M. A., Uddin, M. B., & Mohiuddin, M. S. (2023) · Life · doi:10.3390/life13112213 · Cited by 138
Skeletal muscle adiponectin induction in obesity and exercise
Martínez-Huenchullán, S., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., McLennan, S. V., & Twigg, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154008 · Cited by 119
Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis
Komici, K., Iacono, A. D., Luca, A. D., Perrotta, F., Bencivenga, L., Rengo, G., Rocca, A., & Guerra, G. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.576619 · Cited by 87
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83
Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia
Jang, S. Y., & Choi, K. M. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70000 · Cited by 81
Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space
Rosa, S. C. D. S., Liu, M., & Sweeney, G. (2021) · Physiology · doi:10.1152/physiol.00031.2020 · Cited by 80
Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine–Metabolic Diseases
Iglesias, P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134490 · Cited by 79
Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors
Aslam, M. A., Ma, E. B., & Huh, J. Y. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155711 · Cited by 76
Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72
Adiponectin: friend or foe in obesity and inflammation
Luo, L., & Liu, M. (2022) · Medical Review · doi:10.1515/mr-2022-0002 · Cited by 71
Tissue-specific role and associated downstream signaling pathways of adiponectin
Roy, B., & Palaniyandi, S. S. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00587-4 · Cited by 65
Adipose tissue depot differences in adipokines and effects on skeletal and cardiac muscle
Rodrı́guez, A., Becerril, S., Hernández‐Pardos, A. W., & Frühbeck, G. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.04.003 · Cited by 65
Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise
Paris, M. T., Bell, K. E., & Mourtzakis, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.06.003 · Cited by 66
Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases
Aljafary, M. A., & Al-Suhaimi, E. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071430 · Cited by 52
Adiponectin as a Potential Biomarker for Pregnancy Disorders
Pheiffer, C., Dias, S. C., Jack, B. U., Malaza, N., & Adam, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031326 · Cited by 57
Adiponectin in Chronic Kidney Disease
Przybyciński, J., Dziedziejko, V., Puchałowicz, K., Domański, L., & Pawlik, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249375 · Cited by 50
Body Protein Sparing in Hibernators: A Source for Biomedical Innovation
Bertile, F., Habold, C., Maho, Y. L., & Giroud, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.634953 · Cited by 46
Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
Reddy, I., Yadav, Y., & Dey, C. S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01272-x · Cited by 46
The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
Oțelea, M. R., Nartea, R., Popescu, F. G., Covaleov, A., Mitoiu, B. I., & Nica, A. S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44060181 · Cited by 39
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing
Wilhelmsen, A., Tsintzas, K., & Jones, S. W. (2021) · GeroScience · doi:10.1007/s11357-021-00322-4 · Cited by 42
Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle
Llanos, P., & Palomero, J. (2022) · Cells · doi:10.3390/cells11244008 · Cited by 39
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels
Jian, Y., Yuan, S., Yang, J., Lei, Y., Li, X., & Liu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179921 · Cited by 36
Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition
Hu, K., Edelen, E. D., Zhuo, W., Khan, A. A., Orbegoso, J., Greenfield, L., Rahi, B., Griffin, M. J., Ilich, J. Z., & Kelly, O. J. (2023) · Metabolites · doi:10.3390/metabo13101056 · Cited by 34
The Role of Adiponectin and ADIPOQ Variation in Metabolic Syndrome: A Narrative Review
Błażejewska, W., Dąbrowska, J., Michałowska, J., & Bogdański, P. (2025) · Genes · doi:10.3390/genes16060699 · Cited by 33
Adiponectin and Asthma: Knowns, Unknowns and Controversies
Oțelea, M. R., Arghir, O. C., Zugravu, C., & Rașcu, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168971 · Cited by 31
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells
Sung, H. K., Mitchell, P. L., Gross, S. M., Marette, A., & Sweeney, G. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00603.2020 · Cited by 31
Skeletal Muscle Gene Expression in Long-Term Endurance and Resistance Trained Elderly
Bolotta, A., Filardo, G., Abruzzo, P. M., Astolfi, A., Sanctis, P. D., Martino, A. D., Höfer, C., Indio, V., Kern, H., Löfler, S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113988 · Cited by 30
Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines
Perego, S., Sansoni, V., Ziemann, E., & Lombardi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042005 · Cited by 29
Peripheral to brain and hippocampus crosstalk induced by exercise mediates cognitive and structural hippocampal adaptations
Blume, G. R., & Royes, L. F. F. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122799 · Cited by 27
Probiotics and muscle health: the impact of Lactobacillus on sarcopenia through the gut-muscle axis
Zhu, J., Peng, F., Yang, H., Luo, J., Zhang, L., Chen, X., Liao, H., Lei, H., Liu, S., Yang, T., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1559119 · Cited by 29
Impact of Physical Activity on Disability Risk in Elderly Patients Hospitalized for Mild Acute Diverticulitis and Diverticular Bleeding Undergone Conservative Management
Rocca, A., Brunese, M. C., Cappuccio, M., Scacchi, A., Martucci, G., Buondonno, A., Perrotta, F. M., Quarto, G., Avella, P., & Amato, B. (2021) · Medicina · doi:10.3390/medicina57040360 · Cited by 24
Mechanisms of Adiponectin Action
Fiaschi, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122894 · Cited by 23
Management of Oxidative Stress: Crosstalk Between Brown/Beige Adipose Tissues and Skeletal Muscles
Pan, R., & Chen, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.712372 · Cited by 22
“Ferrocrinology”—Iron Is an Important Factor Involved in Gluco- and Lipocrinology
Szklarz, M., Gontarz-Nowak, K., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Nutrients · doi:10.3390/nu14214693 · Cited by 21
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin
Quattrocelli, M., Wintzinger, M., Miz, K., Panta, M., Prabakaran, A. D., Barish, G. D., Chandel, N. S., & McNally, E. M. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211906 · Cited by 19
White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle
Ford, H. R., Liu, Q., Fu, X., & Strieder‐Barboza, C. (2023) · Biology · doi:10.3390/biology12101289 · Cited by 21
Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
Shinohara, I., Kataoka, T., Mifune, Y., Inui, A., Sakata, R., Nishimoto, H., Yamaura, K., Mukohara, S., Yoshikawa, T., Kato, T., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05608-x · Cited by 18
Association between APOE Genotype with Body Composition and Cardiovascular Disease Risk Markers Is Modulated by BMI in Healthy Adults: Findings from the BODYCON Study
Ozen, E., Mihaylova, R., Lord, N. J., Lovegrove, J. A., & Jackson, K. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179766 · Cited by 18
Adiponectin Decreases Gastric Smooth Muscle Cell Excitability in Mice
Idrizaj, E., Garella, R., Castellini, G., Francini, F., Ricca, V., Baccari, M. C., & Squecco, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01000 · Cited by 18
Different roles of circulating and intramuscular GDF15 as markers of skeletal muscle health
Chiariello, A., Conte, G., Rossetti, L. M., Trofarello, L., Salvioli, S., & Conte, M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1404047 · Cited by 17
Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2
Liu, X., Yang, Y., Shao, H., Liu, S., Niu, Y., & Fu, L. (2022) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2022.08.001 · Cited by 16
Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
Ma, L., Xu, Y., Zhang, Y., Ji, T., & Li, Y. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s242397 · Cited by 16
Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression
Chattopadhyay, S., Joharapurkar, A. A., Das, N., Khatoon, S., Kushwaha, S., Gurjar, A. A., Singh, A. K., Shree, S., Ahmed, M. Z., China, S. P., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111525 · Cited by 16
The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective
Franco‐Obregón, A., Tai, Y. K., Wu, K. Y., Iversen, J. N., & Wong, C. J. K. (2023) · Bioengineering · doi:10.3390/bioengineering10080956 · Cited by 17
Changes Induced by Aging and Long-Term Exercise and/or DHA Supplementation in Muscle of Obese Female Mice
Martínez-Gayo, A., Félix‐Soriano, E., Sáinź, N., González‐Muniesa, P., & Moreno-Aliaga, M. J. (2022) · Nutrients · doi:10.3390/nu14204240 · Cited by 17
Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia
Sharma, A. R., Chatterjee, S., Lee, Y., & Lee, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.00903 · Cited by 15
The Influence of Body Composition, Lifestyle, and Dietary Components on Adiponectin and Resistin Levels and AR Index in Obese Individuals
Polak-Szczybyło, E., & Tabarkiewicz, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010393 · Cited by 13
The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program
Takao, N., Kurose, S., Miyauchi, T., Onishi, K., Tamanoi, A., Tsuyuguchi, R., Fujii, A., Yoshiuchi, S., Takahashi, K., Tsutsumi, H., et al. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00808-4 · Cited by 13
Allulose Attenuated Age‐Associated Sarcopenia via Regulating IGF‐1 and Myostatin in Aged Mice
Kim, J., Kwon, E., & Han, Y. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100549 · Cited by 13
Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition
Lopez‐Yus, M., Lopez-Perez, R., García-Sobreviela, M. P., del Moral, R., Lorente‐Cebrián, S., & Arbonés-Mainar, J. M. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00836-7 · Cited by 13
The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion
Su, L., Pan, Y., & Chen, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.924649 · Cited by 13
VLCKD in Combination with Physical Exercise Preserves Skeletal Muscle Mass in Sarcopenic Obesity after Severe COVID-19 Disease: A Case Report
Camajani, E., Feraco, A., Basciani, S., Gnessi, L., Barrea, L., Armani, A., & Caprio, M. (2022) · Healthcare · doi:10.3390/healthcare10030573 · Cited by 11
Unraveling the Molecular Basis of the Dystrophic Process in Limb-Girdle Muscular Dystrophy LGMD-R12 by Differential Gene Expression Profiles in Diseased and Healthy Muscles
Depuydt, C., Goosens, V., Janky, R., D’Hondt, A., Bleecker, J. D., Noppe, N., Derveaux, S., Thal, D. R., & Claeys, K. G. (2022) · Cells · doi:10.3390/cells11091508 · Cited by 11
Promotion of healthy adipose tissue remodeling ameliorates muscle inflammation in a mouse model of sarcopenic obesity
Ge, Y., Li, S., Yao, T., Tang, Y., Wan, Q., Zhang, X., Zhao, J., Zhang, M., Shao, M., Wang, L., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1065617 · Cited by 10
The role of sex in the relationship between fasting adipokines levels, maximal fat oxidation during exercise, and insulin resistance in young adults with excess adiposity
Chávez-Guevara, I. A., Amaro‐Gahete, F. J., Osuna‐Prieto, F. J., Labayen, I., Aguilera, C. M., & Ruiz, J. R. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115757 · Cited by 10
Body composition and dietary patterns in professional and amateur bodybuilders
Makiel, K., Suder, A., Kasza, S., & Kubasiak, K. (2020) · Anthropological Review · doi:10.2478/anre-2020-0016 · Cited by 10
Endoplasmic reticulum stress and muscle dysfunction in congenital lipodystrophies
Campos, J. T. A. D. M., de Medeiros, J. L. D., de Melo, M. E. C., da Silva, M. A., de Sena, M. O., Sarmento, A. S. C., Agnez‐Lima, L. F., Fregonezi, G., & Lima, J. G. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166120 · Cited by 9
Signaling pathways shaping the field of lipidomics
Ahi, E. P., & House, A. H. (2025) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2025.107053 · Cited by 9
Visceral Fat Affects Heart Rate Recovery but Not the Heart Rate Response Post-Single Bout of Vigorous Exercise: A Cross-Sectional Study in Non-Obese and Healthy Participants
Amato, A., Petrigna, L., Sortino, M., & Musumeci, G. (2024) · Sports · doi:10.3390/sports12120323 · Cited by 8
A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function
Degens, H., Swaminathan, A., & Tallis, J. A. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000261 · Cited by 7
FAT AND MUSCLE COMPONENTS OF BODY WEIGHT AND THEIR RELATIONSHIP WITH THE CONCENTRATION OF SERUM ADIPOKINES IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Pivtorak, K. V., Fedzhaga, I., Pivtorak, N., Vozniuk, L. A., & Klekоt, O. O. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202205210 · Cited by 8
Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats
Lee, S. G., Lee, E., Chae, J., Kim, J. S., Lee, H.-S., Lim, Y.-M., So, J.-H., Hahn, D., & Nam, J. (2022) · Nutrients · doi:10.3390/nu14214683 · Cited by 7
Comparative effectiveness of different exercise modality on glycaemic control and lipid profile for prediabetes: systematic review and network meta-analysis
Yan, R., Chen, L., Lin, G., Shi, Y., Huang, W., Mai, Y., Sun, J., & Li, D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1518871 · Cited by 8
Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction
Bruzina, A. S., Raymond‐Pope, C. J., Murray, K. J., Lillquist, T. J., Castelli, K. M., Bijwadia, S. R., Call, J. A., & Greising, S. M. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00006-5 · Cited by 6
Adiponectin promotes myogenic differentiation via a Mef2C-AdipoR1 positive feedback loop
An, Y., Zheng, Y., Gong, Y.-Q., Yu, R., Yang, Z., & Chen, X. (2020) · Gene · doi:10.1016/j.gene.2020.145380 · Cited by 6
Regulation and Role of Adiponectin Secretion in Rat Ovarian Granulosa Cells
Zhou, Y., Zhang, S., Jia, Y., Wang, X., Liu, Y., Zhang, H., Yuan, Z., Han, Y., & Weng, Q. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105155 · Cited by 6
Association of Cardiopulmonary Exercise Capacity and Adipokines in the General Population
Lendeckel, F., Zylla, S., Markus, M. R. P., Ewert, R., Gläser, S., Völzke, H., Albrecht, D., Friedrich, N., Nauck, M. A., Felix, S. B., et al. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1699-2380 · Cited by 6
RELATIONSHIP OF SERUM ADIPONECTIN LEVELS WITH GLYCAEMIC STATUS IN PREGNANT WOMEN
Akhtar, Y., Nawaz, S., Khan, M. S., Habib, S. H., Malik, M. O., & Fatima, S. (2022) · Journal of Ayub Medical College Abbottabad · doi:10.55519/jamc-02-9491 · Cited by 5
Adiponectin resistance parameter as a marker for high normal blood pres-sure and hypertension in patients with metabolic syndrome.
Stojanovic, S., Deljanin-Ilić, M., Ilić, S., Stefanović, M., Petrović, D., Petrović, V., & Stojanović, M. (2020) · PubMed Central · Cited by 5
RETRACTED: Adiponectin protects skeletal muscle from ischaemia–reperfusion injury in mice through miR ‐21/ PI3K /Akt signalling pathway
Zhou, M., Zhang, H., Chen, H., & Qi, B. (2022) · International Wound Journal · doi:10.1111/iwj.14022 · Cited by 5
Retracted
The combined effects of Tabata training and cinnamon supplementation on metabolic changes and body composition in soldiers with overweight or obesity
Rad, R. S., Omidi, H., & Alipour, M. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2564237 · Cited by 4
Adipose dysfunction, lipid dysregulation, and adipokines in sarcopenia: a systematic review and meta-analysis with sex-specific analyses
Vithran, D. T. A., Hassan, M. H. Y., Rahmati, M., Boyer, L., Wehliye, A. A., Xiao, W., & Li, Y. (2026) · Age and Ageing · doi:10.1093/ageing/afag020 · Cited by 4
Inhibition of obesity through alterations of C/EBP- α gene expression by gum Arabic in mice with a high-fat feed diet
Ahmed, A. A., Musa, H. H., Essa, M. E. A., Mollica, A., Zengin, G., Ahmad, H., & Adam, S. Y. (2022) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2022.100231 · Cited by 5
Maternal Supplementation with a Cocoa Extract during Lactation Deeply Modulates Dams’ Metabolism, Increases Adiponectin Circulating Levels and Improves the Inflammatory Profile in Obese Rat Offspring
Mariné-Casadó, R., Domenech-Coca, C., Crescenti, A., Rodriguez, M. A., Bas-Prior, J. M. D., Arola, L., Boqué, N., & Caimari, A. (2022) · Nutrients · doi:10.3390/nu14235134 · Cited by 4
Paraspinal muscle gene expression across different aetiologies in individuals undergoing surgery for lumbar spine pathology
Ordaz, A., Anderson, B. J., Zlomislic, V., Allen, R. T., Garfin, S. R., Schüpbach, R., Farshad, M., Schenk, S., Ward, S. R., & Shahidi, B. (2023) · European Spine Journal · doi:10.1007/s00586-023-07543-5 · Cited by 4
Time Course of Inflammatory and Endocrine Factors Following a Single-Bout of High-Intensity WB-EMS – A Randomized Crossover Study
Teschler, M., Bothur, E., Samel, N., Waranski, M., Walscheid, R., Schmitz, B., & Mooren, F. C. (2025) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2025.2464195 · Cited by 3
Unravelling the Adiponectin Hallmark and Exploring the Therapeutic Potential of Its Receptor Agonists in Cancer Metabolic Reprogramming
Kafeel, S., Palmiero, G., Salzillo, A., Ragone, A., Naviglio, S., & Sapio, L. (2025) · Biomolecules · doi:10.3390/biom15060820 · Cited by 3
Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy
Moin, M. R., Pal, S., Das, S., Awasthi, P., Talukdar, A., Kumar, A. T. R., Varode, S. S., Nikolas, N., Khatoon, S., Mugale, M. N., et al. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70328 · Cited by 3
Striated Muscle Evaluation Based on Velocity and Amortization Ratio of Mechanical Impulse Propagation in Simulated Microgravity Environment
Nistorescu, A. I., Busnatu, Ș., Dinculescu, A. C., Olteanu, G., Marin, M., Jercălău, C. E., Vizitiu, C., & Papacocea, I. R. (2022) · Biology · doi:10.3390/biology11111677 · Cited by 3
Comparative analysis of paraspinal muscle imbalance between idiopathic scoliosis and congenital scoliosis from the transcriptome aspect
Wang, Z., Zhao, J., Tan, H., Jiao, Y., Chen, X., & Shen, J. (2024) · JOR Spine · doi:10.1002/jsp2.1318 · Cited by 3
Connecting bone metastasis, adipose tissue and adipokines: How does physical activity fit?
Maroni, P., Gomarasca, M., Signo, M., & Lombardi, G. (2024) · Advanced Exercise and Health Science · doi:10.1016/j.aehs.2024.08.001 · Cited by 3
Adiponectin Concentration and Chronic Stroke Individuals, Associations with Body Composition, Physical Activity Levels and Lipid Profile: A Cross-Sectional Explorative Study
García-Salazar, L. F., Ribeiro, J. A. M., Saade-Pacheco, C. R., Mattiello, S. M., Catai, A. M., Garcia-Araújo, A. S., & Russo, T. L. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105993 · Cited by 3
Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles
Ishiguro, H., Minato, K., Iwaasa, K., Wu, S., Antao, G., Tsuchida, T., Suwabe, T., Katagiri, T., Suzuki, H., Masuko, M., et al. (2025) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2025.109145 · Cited by 2
Beyond BMI: The musculoskeletal and metabolic consequences of normal weight obesity across the female lifespan
Frost, A., Hirsch, K. R., R, J. A., Gagnon, S., Smith‐Ryan, A. E., Ormsbee, M. J., J, C. A., A, B. P., E, M. J., N, D. R., et al. (2026) · Women s Health · doi:10.1177/17455057261455585 · Cited by 2
Effects of 1,144 km of road cycling performed in 7 days: a cardiometabolic imaging study
Chartrand, D. J., Murphy-Després, A., Lemieux, I., Larose, É., Poirier, P., Després, J., & Alméras, N. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00098.2024 · Cited by 2
Injection of Adipose-Derived Mesenchymal Stem/Stromal Cells Suppresses Muscle Atrophy Markers and Adipogenic Markers in a Rat Fatty Muscle Degeneration Model
Ngeun, S. K., Shimizu, M., & Kaneda, M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080467 · Cited by 2
Circulating Muscle Markers for Sarcopenia in Peritoneal Dialysis
Xu, L., Ng, J. K., Fung, W. W., Chan, G. C., Chow, K., & Szeto, C. (2025) · International Journal of Nephrology · doi:10.1155/ijne/8817404 · Cited by 2
Altered adiponectin regulation in skeletal muscle of patients with chronic kidney disease
Verzola, D., Saio, M., Milanesi, S., Picciotto, D., Frascio, M., Brunori, G., Laudon, A., Porta, E. L., Rumeo, N., Zanetti, V., et al. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae051 · Cited by 2
Empathy, stress and biopsychological homeostasis. Hormonal-loop disorders theoryPreprint
Naumov, D. (2022) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/qyra3 · Cited by 2
Down regulation of the inverse relationship between parathyroid hormone and irisin in male vitamin D-sufficient HIV patients
Karras, S. Ν., Koufakis, T., Dimakopoulos, G., Zisimopoulou, E., Mourampetzis, P., Manthou, E., Karalazou, P., Thisiadou, K., Tsachouridou, Ο., Zebekakis, P. E., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02112-5 · Cited by 1
Role of adiponectin in gestational diabetes mellitus: advances in mechanistic insights and early predictive potential
Chen, Y., He, F., Zhang, L., & Zhang, Z. (2026) · Adipocyte · doi:10.1080/21623945.2026.2705620 · Cited by 1
Obesity, inflammation and muscle weakness
Hasselgren, P.-O. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90960-0.00014-x · Cited by 1
Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations
Herscovici, D. M., Cooper, K. M., Colletta, A., Rightmyer, M., Shingina, A., & Feld, L. D. (2024) · World Journal of Transplantation · doi:10.5500/wjt.v14.i2.90202 · Cited by 1
Age-related adiponectin resistance in human skeletal muscle dysfunction: in vivo and in vitro evidence
Surina, S., Scisciola, L., Basilicata, M. G., Pesapane, A., Fontanella, R. A., Balzano, N., Palazzo, A., Zia, A., Tortorella, G., Ulfat, Z., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07959-9 · Cited by 1
Physical activity enhances fecal lactobacilli in rats chronically drinking sweetened cola beverage
Marušáková, M., Dudík, B., Hadová, K., Kmecová, Z., Kráľová, E., Křenek, P., Bilková, A., & Klimas, J. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0070 · Cited by 1
Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study
Yang, S., Liao, K., Zhou, L., Zhang, S., & Wu, J.-C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1597065 · Cited by 1
Evaluation of adiponectin serum levels and their association with oxidative stress in individuals with type 2 diabetes mellitus in Iraq
Al-Dulaimy, A. H., & Ghafoor, K. F. A. (2024) · Anaesthesia Pain & Intensive Care · doi:10.35975/apic.v28i3.2475 · Cited by 1

Authors: Krause, M. P., Milne, K. J., & Hawke, T. J.
Affiliations: University of Windsor (CA)
McMaster University (CA)
Corresponding author: Krause, Matthew P.
ORCID: Krause, Matthew P.
Milne, Kevin J.
Hawke, Thomas J.
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2019-03-27
Volume: 20
Issue: 7
Pages: 1528
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms20071528
PMC: PMC6480271
OpenAlex: W2924066250
Cited by: 121
References: 121
Citations by year: 2026: 11 · 2025: 15 · 2024: 15 · 2023: 11 · 2022: 32 · 2021: 21 · 2020: 11 · 2019: 5
FWCI: 2.51
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-05073)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adiponectin, skeletal muscle, adipokines, paracrine signaling, muscle regeneration, chronic inflammation, physical activity, insulin sensitivity, obesity, diabetes mellitus, blood glucose regulation, fatty acid oxidation
MeSH terms: Autophagy, Humans, Protein Processing, Post-Translational, Regeneration, Exercise, Muscle, Skeletal, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adiponectin—Consideration for its Role in Skeletal Muscle Health

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks