Cited by 123Adipokines, Inflammation, and Metabolic DiseasesMuscle Physiology and DisordersAdipose Tissue and Metabolism

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Adiponectin—Consideration for its Role in Skeletal Muscle Health

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Krause, Matthew P., Milne, Kevin J., Hawke, Thomas J.·2019·International Journal of Molecular Sciences

DOI 10.3390/ijms20071528PMC PMC6480271

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Abstract

Adiponectin regulates metabolism through blood glucose control and fatty acid oxidation, partly mediated by downstream effects of adiponectin signaling in skeletal muscle. More recently, skeletal muscle has been identified as a source of adiponectin expression, fueling interest in the role of adiponectin as both a circulating adipokine and a locally expressed paracrine/autocrine factor. In addition to being metabolically responsive, skeletal muscle functional capacity, calcium handling, growth and maintenance, regenerative capacity, and susceptibility to chronic inflammation are all strongly influenced by adiponectin stimulation. Furthermore, physical exercise has clear links to adiponectin expression and circulating concentrations in healthy and diseased populations. Greater physical activity is generally related to higher adiponectin expression while lower adiponectin levels are found in inactive obese, pre-diabetic, and diabetic populations. Exercise training typically restores plasma adiponectin and is associated with improved insulin sensitivity. Thus, the role of adiponectin signaling in skeletal muscle has expanded beyond that of a metabolic regulator to include several aspects of skeletal muscle function and maintenance critical to muscle health, many of which are responsive to, and mediated by, physical exercise.

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Figure 1 Proposed relationships between adiponectin, exercise, and skeletal muscle function. Multiple isoforms including the proteolytically cleaved globular isoform signal to tissue including skeletal muscle, satellite cells, myoblasts, and differentiated myotubes. Physical exercise generally stimulates increases in adiponectin expression and signaling. Skeletal muscle health is ultimately improved with sufficient adiponectin signaling via improved cellular functions such as autophagy and regeneration and suppression of inflammation, endoplasmic reticulum (ER) stress, and proteolysis. Solid arrows represent relationships, effects, or interactions that are clearly defined in the literature. Broken arrows with “?” represent relationships, effects, or interactions that are not clearly defined in the literature.CC BY · PubMed Central

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Authors: Krause, M. P., Milne, K. J., & Hawke, T. J.
Affiliations: University of Windsor (CA)
McMaster University (CA)
Corresponding author: Krause, Matthew P.
ORCID: Krause, Matthew P.
Milne, Kevin J.
Hawke, Thomas J.
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2019-03-27
Volume: 20
Issue: 7
Pages: 1528
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms20071528
PMC: PMC6480271
OpenAlex: W2924066250
Cited by: 121
References: 121
Citations by year: 2026: 11 · 2025: 15 · 2024: 15 · 2023: 11 · 2022: 32 · 2021: 21 · 2020: 11 · 2019: 5
FWCI: 2.51
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-05073)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adiponectin, skeletal muscle, adipokines, paracrine signaling, muscle regeneration, chronic inflammation, physical activity, insulin sensitivity, obesity, diabetes mellitus, blood glucose regulation, fatty acid oxidation
MeSH terms: Autophagy, Humans, Protein Processing, Post-Translational, Regeneration, Exercise, Muscle, Skeletal, Adiponectin

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Adiponectin—Consideration for its Role in Skeletal Muscle Health

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