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Cited by 282

The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.

From Extraction to Advanced Analytical Methods: The Challenges of Melanin Analysis

Open access
Pralea, Ioana-Ecaterina, Moldovan, Radu-Cristian, Petrache, Alina-Maria, Ilieș, Maria, Hegheș, Simona-Codruța, Ielciu, Irina, Nicoară, Raul, Moldovan, Mirela, Ene, Mihaela, Radu, Mihai, Uifălean, Alina, Iuga, Cristina-Adela·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20163943
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Abstract

The generic term “melanin“ describes a black pigment of biological origin, although some melanins can be brown or even yellow. The pigment is characterized as a heterogenic polymer of phenolic or indolic nature, and the classification of eu-, pheo- and allo- melanin is broadly accepted. This classification is based on the chemical composition of the monomer subunit structure of the pigment. Due to the high heterogeneity of melanins, their analytical characterization can be a challenging task. In the present work, we synthesized the current information about the analytical methods which can be applied in melanin analysis workflow, from extraction and purification to high-throughput methods, such as matrix-assisted laser desorption/ionization mass-spectrometry or pyrolysis gas chromatography. Our thorough comparative evaluation of analytical data published so far on melanin analysis has proven to be a difficult task in terms of finding equivalent results, even when the same matrix was used. Moreover, we emphasize the importance of prior knowledge of melanin types and properties in order to select a valid experimental design using analytical methods that are able to deliver reliable results and draw consistent conclusions.

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Metadata

Authors
Pralea, I.-E., Moldovan, R.-C., Petrache, A.-M., Ilieș, M., Hegheș, S.-C., Ielciu, I., Nicoară, R., Moldovan, M., Ene, M., Radu, M., Uifălean, A., & Iuga, C.-A.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-08-13
Volume
20
Issue
16
Pages
3943
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20163943
OpenAlex
W2968325215
Cited by
282
References
129
FWCI
10.64
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: From Extraction to Advanced Analytical Methods: The Challenges of Melanin Analysis. https://app.cochat.ai/papers/10.3390/ijms20163943
The paper
Pralea, I.-E., Moldovan, R.-C., Petrache, A.-M., Ilieș, M., Hegheș, S.-C., Ielciu, I., Nicoară, R., Moldovan, M., Ene, M., Radu, M., Uifălean, A., & Iuga, C.-A. (2019). From Extraction to Advanced Analytical Methods: The Challenges of Melanin Analysis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20163943

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.