Corylifol A from Psoralea corylifolia L. Enhances Myogenesis and Alleviates Muscle Atrophy
Open accessAbstract
Inflammatory conditions caused by cancer, chronic diseases or aging can lead to skeletal muscle atrophy. We identified myogenic compounds from Psoralea corylifolia (PC), a medicinal plant that has been used for the treatment of inflammatory and skin diseases. C2C12 mouse skeletal myoblasts were differentiated in the presence of eight compounds isolated from PC to evaluate their myogenic potential. Among them, corylifol A showed the strongest transactivation of MyoD and increased expression of myogenic markers, such as MyoD, myogenin and myosin heavy chain (MHC). Corylifol A increased the number of multinucleated and MHC-expressing myotubes. We also found that the p38 MAPK signaling pathway is essential for the myogenic action of corylifol A. Atrophic condition was induced by treatment with dexamethasone. Corylifol A protected against dexamethasone-induced myotube loss by increasing the proportion of multinucleated MHC-expressing myotubes compared with dexamethasone-damaged myotubes. Corylifol A reduced the expression of muscle-specific ubiquitin-E3 ligases (MAFbx and MuRF1) and myostatin, while activating Akt. These dual effects of corylifol A, inhibition of catabolic and activation of anabolic pathways, protect myotubes against dexamethasone damage. In summary, corylifol A isolated from P. corylifolia alleviates muscle atrophic condition through activating myoblast differentiation and suppressing muscle degradation in atrophic conditions.
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Corylifol A enhances myogenesis in C2C12 cells via the activation of p38 MAPKs.
“Corylifol A, a phenolic compound from Psoralea corylifolia L., enhances myogenesis in C2C12 cells via the activation of p38 MAPKs.”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [101]
Corylifol A inhibits dexamethasone-induced muscle atrophy in C2C12 cells, related to inhibition of catabolic pathways and activation of the anabolic pathway.
“It also inhibits dexamethasone-induced muscle atrophy in C2C12 cells, which is related to the inhibition of catabolic pathways and the activation of the anabolic pathway [101].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [101]
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- Authors
- Han, Y., Lee, H., Li, H., & Ryu, J.-H.
- Affiliations
- Sookmyung Women's University (KR)
- Research Institute of Pharmaceutical Sciences and College of Pharmacy, Sookmyung Women’s University, 100 Chungparo 47-Gil, Yongsan-Gu, Seoul 04310, Korea
- Corresponding author
- Ryu, Jae-Ha
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-02-25
- Volume
- 21
- Issue
- 5
- Pages
- 1571
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7084366
- OpenAlex
- W3006795980
- Cited by
- 34
- References
- 47
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Sookmyung Women's University (1-201809-6)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- Psoralea corylifolia, skeletal muscle atrophy, myogenesis, p38 MAPK signaling, dexamethasone-induced atrophy, atrogin-1, MuRF1, myostatin, Akt signaling, MyoD, myosin heavy chain, muscle degradation, medicinal plant constituents
- MeSH terms
- Tripartite Motif Proteins, Animals, Cell Line, Muscle Proteins, Muscular Atrophy, MyoD Protein, Muscle Fibers, Skeletal, Myosin Heavy Chains, Muscle Development, Ubiquitin-Protein Ligases, Flavones, p38 Mitogen-Activated Protein Kinases, Mice
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