Cited by 45Muscle Physiology and DisordersNutrition and Health in AgingExercise and Physiological Responses

Flavonoids: Nutraceutical Potential for Counteracting Muscle Atrophy

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Kim, Changhee, Hwang, Jae-Kwan·2020·Food Science and Biotechnology

Abstract

Skeletal muscle plays a vital role in the conversion of chemical energy into physical force. Muscle atrophy, characterized by a reduction in muscle mass, is a symptom of chronic disease (cachexia), aging (sarcopenia), and muscle disuse (inactivity). To date, several trials have been conducted to prevent and inhibit muscle atrophy development; however, few interventions are currently available for muscle atrophy. Recently, food ingredients, plant extracts, and phytochemicals have received attention as treatment sources to prevent muscle wasting. Flavonoids are bioactive polyphenol compounds found in foods and plants. They possess diverse biological activities, including anti-obesity, anti-diabetes, anti-cancer, anti-oxidation, and anti-inflammation. The effects of flavonoids on muscle atrophy have been investigated by monitoring molecular mechanisms involved in protein turnover, mitochondrial activity, and myogenesis. This review summarizes the reported effects of flavonoids on sarcopenia, cachexia, and disuse muscle atrophy, thus, providing an insight into the understanding of the associated molecular mechanisms.

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  • Evidence from preclinical studies reveals nutraceuticals play a significant role in maintaining muscle health and are potential therapeutic agents in a broad range of muscle atrophy models.

    “Evidence from various preclinical studies has revealed that nutraceuticals play a significant role in maintaining muscle health and emerge as potential therapeutic agents in a broad range of muscle atrophy models [17,18].”
  • Phytochemicals play an essential role in the prevention and treatment of muscle atrophy, especially in reducing muscle protein degradation and promoting muscle protein synthesis.

    “Collectively, phytochemicals play an essential role in the prevention and treatment of muscle atrophy, especially in reducing muscle protein degradation and promoting muscle protein synthesis [17,18].”

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Authors
Kim, C., & Hwang, J.-K.
Affiliations
Yonsei University (KR)
Corresponding author
Hwang, Jae-Kwan
Venue
Food Science and Biotechnology
Published
2020-09-16
Volume
29
Issue
12
Pages
1619-1640
ISSN
  • 1226-7708 (ISSN-L)
  • 2092-6456
OpenAlex
W3091973957
Cited by
45
References
144
Citations by year
2026: 11 · 2025: 3 · 2024: 13 · 2023: 9 · 2022: 4 · 2021: 5
FWCI
0.43
Type
journal article
Language
en
Open access
Locations
  • Food Science and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Ministry of Agriculture, Food and Rural Affairs (320011-02)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
flavonoids, muscle atrophy, sarcopenia, cachexia, disuse atrophy, nutraceuticals, polyphenols, protein turnover, mitochondrial activity, myogenesis, anti-inflammatory activity, anti-oxidation, plant extracts

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