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Cited by 411

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

The p38 Pathway: From Biology to Cancer Therapy

Open access
Martínez-Limón, Adrián, Joaquin, Manel, Caballero, María, Posas, Francesc, de Nadal, Eulàlia·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21061913
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Abstract

The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 participates in a broad range of cellular activities, for many of which detailed molecular pictures are still lacking. Originally described as a tumor-suppressor kinase for its inhibitory role in RAS-dependent transformation, p38 can also function as a tumor promoter, as demonstrated by extensive experimental data. This finding has prompted the development of specific inhibitors that have been used in clinical trials to treat several human malignancies, although without much success to date. However, elucidating critical aspects of p38 biology, such as isoform-specific functions or its apparent dual nature during tumorigenesis, might open up new possibilities for therapy with unexpected potential. In this review, we provide an extensive description of the main biological functions of p38 and focus on recent studies that have addressed its role in cancer. Furthermore, we provide an updated overview of therapeutic strategies targeting p38 in cancer and promising alternatives currently being explored.

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Metadata

Authors
Martínez-Limón, A., Joaquin, M., Caballero, M., Posas, F., & de Nadal, E.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-03-11
Volume
21
Issue
6
Pages
1913
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21061913
OpenAlex
W3010908253
Cited by
411
References
123
FWCI
14.94
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The p38 Pathway: From Biology to Cancer Therapy. https://app.cochat.ai/papers/10.3390/ijms21061913
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Martínez-Limón, A., Joaquin, M., Caballero, M., Posas, F., & de Nadal, E. (2020). The p38 Pathway: From Biology to Cancer Therapy. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21061913

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.