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Mechanisms and functions of p38 MAPK signalling

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Cuadrado, Ana, Nebreda, Angel R.·2010·Biochemical Journal
DOI 10.1042/bj20100323
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Abstract

The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes is achieved with an apparently simple linear architecture of the pathway, consisting of a core of three protein kinases acting sequentially. In the present review, we dissect the molecular mechanisms underlying p38 MAPK functions, with special emphasis on the activation and regulation of the core kinases, the interplay with other signalling pathways and the nature of p38 MAPK substrates as a source of functional diversity. Finally, we discuss how genetic mouse models are facilitating the identification of physiological functions for p38 MAPKs, which may impinge on their eventual use as therapeutic targets.

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Cited by

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Metadata

Authors
Cuadrado, A., & Nebreda, A. R.
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
2010-07-14
Volume
429
Issue
3
Pages
403-417
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
DOI
10.1042/bj20100323
OpenAlex
W2149848093
Cited by
1,676
References
15
FWCI
30.60
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Mechanisms and functions of p38 MAPK signalling. https://app.cochat.ai/papers/10.1042/bj20100323
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Cuadrado, A., & Nebreda, A. R. (2010). Mechanisms and functions of p38 MAPK signalling. Biochemical Journal. https://doi.org/10.1042/bj20100323

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