The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome
Open accessAbstract
Obesity has become a global epidemic and a public health crisis in the Western World, experiencing a threefold increase in prevalence since 1975. High-caloric diets and sedentary lifestyles have been identified as significant contributors to this widespread issue, although the role of genetic, social, and environmental factors in obesity’s pathogenesis remain incompletely understood. In recent years, much attention has been drawn to the contribution of the gut microbiota in the development of obesity. Indeed, research has shown that in contrast to their healthier counterparts the microbiomes of obese individuals are structurally and functionally distinct, strongly suggesting microbiome as a potential target for obesity therapeutics. In particular, pre and probiotics have emerged as effective and integrative means of modulating the microbiome, in order to reverse the microbial dysbiosis associated with an obese phenotype. The following review brings forth animal and human research supporting the myriad of mechanisms by which the microbiome affects obesity, as well as the strengths and limitations of probiotic or prebiotic supplementation for the prevention and treatment of obesity. Finally, we set forth a roadmap for the comprehensive development of functional food solutions in combatting obesity, to capitalize on the potential of pre/probiotic therapies in optimizing host health.
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Cites
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Diet rapidly and reproducibly alters the human gut microbiome
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The gut microbiota as an environmental factor that regulates fat storage
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Cited by
Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss
Reiss, A. B., Gulkarov, S., Lau, R., Klek, S. P., Srivastava, A., Renna, H. A., & De Leon, J. (2025) · Biomolecules · doi:10.3390/biom15030408 · Cited by 58
Ma, Y., Nenkov, M., Chen, Y., & Gaßler, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158352 · Cited by 28
Aimaretti, E., Porchietto, E., Mantegazza, G., Gargari, G., Collotta, D., Einaudi, G., Ferreira Alves, G., Marzani, E., Algeri, A., Dal Bello, F., et al. (2024) · Nutrients · doi:10.3390/nu16040552 · Cited by 4
Metadata
- Authors
- Green, M., Arora, K., & Prakash, S.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-04-21
- Volume
- 21
- Issue
- 8
- Pages
- 2890
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3019830114
- Cited by
- 293
- References
- 37
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Green, M., Arora, K., & Prakash, S. (2020). Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21082890
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
