The Role of Adipocytes Recruited as Part of Tumor Microenvironment in Promoting Colorectal Cancer Metastases
Open accessAbstract
Adipose tissue dysfunction, which is associated with an increased risk of colorectal cancer (CRC), is a significant factor in the pathophysiology of obesity. Obesity-related inflammation and extracellular matrix (ECM) remodeling promote colorectal cancer metastasis (CRCM) by shaping the tumor microenvironment (TME). When CRC occurs, the metabolic symbiosis of tumor cells recruits adjacent adipocytes into the TME to supply energy. Meanwhile, abundant immune cells, from adipose tissue and blood, are recruited into the TME, which is stimulated by pro-inflammatory factors and triggers a chronic local pro-inflammatory TME. Dysregulated ECM proteins and cell surface adhesion molecules enhance ECM remodeling and further increase contractibility between tumor and stromal cells, which promotes epithelial-mesenchymal transition (EMT). EMT increases tumor migration and invasion into surrounding tissues or vessels and accelerates CRCM. Colorectal symbiotic microbiota also plays an important role in the promotion of CRCM. In this review, we provide adipose tissue and its contributions to CRC, with a special emphasis on the role of adipocytes, macrophages, neutrophils, T cells, ECM, and symbiotic gut microbiota in the progression of CRC and their contributions to the CRC microenvironment. We highlight the interactions between adipocytes and tumor cells, and potential therapeutic approaches to target these interactions.
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Adipocytes constitute a significant stromal component in the tumor microenvironment of several malignancies, including breast, ovarian, and colorectal cancers.
“Adipocytes constitute a significant stromal component in the TME of several malignancies, including breast, ovarian, and colorectal cancers [57,58].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [58]
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Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer
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Flagged first, then by citations
4 of the 303 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
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“Adipocytes constitute a significant stromal component in the TME of several malignancies, including breast, ovarian, and colorectal cancers [57,58].”
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- Authors
- Ma, Y., Nenkov, M., Chen, Y., & Gaßler, N.
- Affiliations
- Jena University Hospital (DE)
- Corresponding author
- Gaßler, Nikolaus
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2024-07-30
- Volume
- 25
- Issue
- 15
- Pages
- 8352
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC11313311
- OpenAlex
- W4401179263
- Cited by
- 28
- References
- 303
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 2
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Common Library Network (Der Gemeinsame Bibliotheksverbund) (submittedVersion, cc-by)
- Funders
- University Hospital Jena, Germany (512648189)
- German Research Foundation Projekt (512648189)
- Open Access Publication Fund of the Thueringer Universitaets- und Landesbibliothek Jena (512648189)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- colorectal cancer, metastasis, tumor microenvironment, adipocytes, adipose tissue dysfunction, obesity, extracellular matrix remodeling, epithelial-mesenchymal transition, tumor-stroma interactions, tumor-associated macrophages, neutrophils, T cells, gut microbiota, inflammation, tumor energy metabolism
- MeSH terms
- Gastrointestinal Microbiome, Adipose Tissue, Animals, Extracellular Matrix, Humans, Neoplasm Metastasis, Colorectal Neoplasms, Adipocytes, Epithelial-Mesenchymal Transition, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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