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Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model

Aimaretti, Eleonora, Porchietto, Elisa, Mantegazza, Giacomo, Gargari, Giorgio, Collotta, Debora, Einaudi, Giacomo, Ferreira Alves, Gustavo, Marzani, Enrica +7 more·2024·Nutrients
DOI 10.3390/nu16040552PMC PMC10892558
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Abstract

Advanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga Arthrospira platensis (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements. Thirty male C57Bl6 mice were fed a standard diet (SD) or a high-fat high-sugar diet (HFHS) for 12 weeks, and a subgroup of HFHS mice received 350 mg/kg Zn-SP three times a week. A HFHS diet induced obesity and glucose intolerance and increased plasma levels of pro-inflammatory cytokines and transaminases. Zn-SP administration restored glucose homeostasis and reduced hepatic dysfunction and systemic inflammation. In the liver of HFHS mice, a robust accumulation of AGEs was detected, paralleled by increased expression of the main AGE receptor (RAGE) and depletion of glyoxalase-1, whereas Zn-SP administration efficiently prevented these alterations reducing local pro-inflammatory responses. 16S rRNA gene profiling of feces and ileum content revealed altered bacterial community structure in HFHS mice compared to both SD and HFHS + Zn-SP groups. Overall, our study demonstrates relevant anti-glycation properties of Zn-SP which contribute to preventing AGE production and/or stimulate AGE detoxification, leading to the improvement of diet-related dysbiosis and metabolic derangements.

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  • Spirulina has been experimentally proven safe in chronic and acute administrations in the liver, kidneys, reproductive system, and overall human physiology.

    “has been experimentally proven to be safe in both chronic and acute administrations in the liver, kidneys, reproductive system, and overall human physiology [9].”

    From Spirulina Supplementation Alleviates Intense Exercise-Induced Damage and Modulates Gut Microbiota in Mice (2025) · cites this paper as [9]

    The Discussion reports improved liver-injury markers after chronic administration of zinc-enriched spirulina to high-fat/high-sugar-fed mice, which offers limited support for the liver-related portion of the claim. It does not establish safety under acute administration or assess kidney, reproductive, or overall human safety. (LLM, conf=0.82)

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Authors
Aimaretti, E., Porchietto, E., Mantegazza, G., Gargari, G., Collotta, D., Einaudi, G., Ferreira Alves, G., Marzani, E., Algeri, A., Dal Bello, F., Aragno, M., Cifani, C., Guglielmetti, S., Mastrocola, R., & Collino, M.
Venue
Nutrients
Publisher
MDPI AG
Published
2024-02-17
Volume
16
Issue
4
Pages
552
ISSN
2072-6643
DOI
10.3390/nu16040552
PMC
PMC10892558
Cited by
4
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • University of Turin (1170–Carb-Q-4-Health, 20224PR8HE)
  • Italian Ministry of Agricultural, Food and Forestry Policies (1170–Carb-Q-4-Health, 20224PR8HE)
  • Italian Ministry of Education, Universities and Research (1170–Carb-Q-4-Health, 20224PR8HE)

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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