The effects of continuous and withdrawal voluntary wheel running exercise on the expression of senescence-related genes in the visceral adipose tissue of young mice
Open accessAbstract
Obesity has become a global medical problem. The upregulation of senescence-related markers in adipose tissue may cause impairment of adipose tissue and disorders of systemic metabolism. Weight control through diet has been found to ameliorate senescence in the adipose tissue. Exercise is also important in maintaining a healthy lifestyle, however, very few researchers have examined the relationship between senescence-related markers in adipose tissue. Dietary restriction is also reported to have a legacy effect, wherein the effects are maintained for some periods after the termination of the intervention. However, very few researchers have examined the relationship between exercise and senescence-related markers in adipose tissue. Besides, there is no study on the long-term effects of exercise. Hence, we investigated whether the exercise could change the expression of senescence-related genes in the visceral adipose tissue of young mice and whether there was a legacy effect of exercise for 10 weeks after the termination of exercise. Four-week-old male ICR mice were assigned to one of the three groups: 20 weeks of sedentary condition, 20 weeks of voluntary wheel running exercise, or 10 weeks of exercise followed by 10 weeks of sedentary condition. The mice showed decreased expression in genes related to senescence and senescence-associated secretory phenotype, such as p53, p16, and IL-6, in the visceral adipose tissue in response to exercise. These effects were maintained for 10 weeks after the mice stopped exercising. Our study is the first report that exercise reduces the expression of senescence-related genes in the visceral adipose tissue of young mice, and that exercise causes the legacy effect.
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In 4-wk-old mice, 10 wk of wheel running followed by 10 wk of sedentary behavior lowered senescence markers, suggesting a legacy effect of exercise on the senescence program.
“These senescence markers were also lower in 4-wk-old mice that underwent 10 wk of wheel running followed by 10 wk of sedentary behavior, suggesting a legacy effect of exercise on the senescence program (53).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [53]
In young male mice, 20 wk of voluntary wheel running lowered senescence markers.
“of young male mice after 20 wk of voluntary wheel running.”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [53]
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- Authors
- Kimura, M., Suzuki, S., Moriya, A., Nogami, K., Uchida, R., Saito, Y., & Saito, H.
- Affiliations
- Keio University (JP)
- Corresponding author
- Kimura, Masaki
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-12-29
- Volume
- 22
- Issue
- 1
- Pages
- 264
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7794976
- OpenAlex
- W3117248391
- Cited by
- 11
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (JP19K11773, JP16K01831, JP24650449)
- The Nateglinide Memorial Toshima Research and Education Foundation (Research Grant)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- voluntary wheel running, physical activity, senescence, visceral adipose tissue, senescence-associated secretory phenotype, p53, p16, interleukin-6, legacy effects, obesity, young mice, gene expression
- MeSH terms
- Aging, Animals, Energy Metabolism, Gene Expression Regulation, Glucose, Male, Physical Conditioning, Animal, Biomarkers, Computational Biology, Gene Expression Profiling, Intra-Abdominal Fat, Mice, Adipokines, Gene Ontology
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